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Carbon-Related Materials for Bioengineering
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Carbon-Related Materials for Bioengineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 6285

Special Issue Editor

Prof. Dr. Mariana Ionita

E-Mail Website
Guest Editor
Advanced Polymer Materials Group, University Politehnica of Bucharest, Calea Victorie 147, 010737 Bucharest, Romania
Interests: carbon-based nanomotors; super carbonaceous structures; tissue regeneration; scaffold for hard tissue regeneration; graphene-based biomaterials; graphene-based optical microRNA sensors; graphene-based electrochemical microRNA sensors; multifunctional polymer/graphene materials; graphene-based novel architectures for biomedical applications; in vitro and in vivo assessment of carbon-related materials; computer-aided design of carbon-related materials

Special Issue Information

Dear Colleagues,

I am very pleased to invite you to submit your work to the Special Issue on “Carbon-Related Materials for Bioengineering”. Despite the novelty of carbon-related materials, they have significantly influenced the landscape of bioengineering by providing a much-improved effectiveness and economically feasible alternatives for the current solutions in several areas of the field. This Special Issue of Materials on “Carbon-Related Materials for Bioengineering” focuses on the methods that have been developed and applied to produce and functionalize hierarchically exquisite carbon structures and also covers advanced characterization, computational, physical, and biological aspects.

This Special Issue aims to bring together leading researchers to exchange and share their findings for the development of carbon-based products. Carbon-related materials are considered very promising for high-end electronics, while their versatile and tunable features allow for ground-breaking bioengineering applications when creatively used.  The manuscripts to be featured include original research, review, mini-review, and perspective articles. Themes to be investigated may include but are not limited to:

  • Carbon-related materials development;
  • Carbon-related materials characterization;
  • Implantable devices, drug delivery systems, bionanotechnology, and tissue engineering based on carbon materials;
  • Carbon-related material composites for industrial applications based on commercial demand;
  • Computer-aided design and investigation of carbon-related materials;
  • Carbon-related materials for biosensing devices.

Prof. Dr. Mariana Ionita
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • carbon-related biomaterials
  • carbon-based novel architectures for health applications
  • modification of carbon materials
  • exploratory studies of carbon-based biomaterials
  • computer-aided design of carbon-related materials

Published Papers (3 papers)

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Research

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18 pages, 5103 KiB  
Article
Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes
by Alin Georgian Toader, George Mihail Vlasceanu, Andrada Serafim, Adela Banciu and Mariana Ionita
Materials 2023, 16(5), 1815; https://0-doi-org.brum.beds.ac.uk/10.3390/ma16051815 - 22 Feb 2023
Cited by 1 | Viewed by 1172
Abstract
Genipin crosslinked composite blends of fish gelatin/kappa-carrageenan (fG/κC) with different concentrations of graphene oxide (GO) for osteochondral substitutes were prepared by a simple solution-blending method. The resulting structures were examined by micro-computer tomography, swelling studies, enzymatic degradations, compressions tests, MTT, LDH, and LIVE/DEAD [...] Read more.
Genipin crosslinked composite blends of fish gelatin/kappa-carrageenan (fG/κC) with different concentrations of graphene oxide (GO) for osteochondral substitutes were prepared by a simple solution-blending method. The resulting structures were examined by micro-computer tomography, swelling studies, enzymatic degradations, compressions tests, MTT, LDH, and LIVE/DEAD assays. The derived findings revealed that genipin crosslinked fG/κC blends reinforced with GO have a homogenous morphology with ideal pore dimensions of 200–500 µm for bones alternative. GO additivation with a concentration above 1.25% increased the blends’ fluid absorption. The full degradation of the blends occurs in 10 days and the gel fraction stability increases with GO concentration. The blend compression modules decrease at first until fG/κC GO3, which has the least elastic behavior, then by raising the GO concentration the blends start to regain elasticity. The MC3T3-E1 cell viability reveals less viable cells with the increase of GO concentration. The LDH together with the LIVE/DEAD assays reports a high concentration of live and healthy cells in all types of composite blends and very few dead cells at the higher GO content. Full article
(This article belongs to the Special Issue Carbon-Related Materials for Bioengineering)
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17 pages, 4455 KiB  
Article
Development of New Hybrid Casein-Loaded PHEMA-PEGDA Hydrogels with Enhanced Mineralisation Potential
by Georgiana-Dana Dumitrescu, Andrada Serafim, Raluca-Elena Ginghina, Horia Iovu, Rodica Marinescu, Elena Olăreț and Izabela-Cristina Stancu
Materials 2022, 15(3), 840; https://0-doi-org.brum.beds.ac.uk/10.3390/ma15030840 - 22 Jan 2022
Cited by 3 | Viewed by 1840
Abstract
Casein is a micellar protein rich in glutamic and aspartic acids as well as in phosphoserine. Considering its native affinity for calcium and the connection of sub-micelles through calcium phosphate nanoclusters, this protein holds promise for stimulating biomimetic mineralisation phenomena and direct binding [...] Read more.
Casein is a micellar protein rich in glutamic and aspartic acids as well as in phosphoserine. Considering its native affinity for calcium and the connection of sub-micelles through calcium phosphate nanoclusters, this protein holds promise for stimulating biomimetic mineralisation phenomena and direct binding with the mineral phase of hard tissues. In this work we prepared new hybrids based on casein embedded in a poly(2-hydroxyethyl methacrylate)-polyethyleneglycol diacrylate (PHEMA-PEGDA) hydrogel. The resulting materials were investigated structurally by Fourier transform infrared (FT-IR). Casein modified the water affinity and the rheological properties of the hybrids. The microstructure was explored by scanning electron microscopy (SEM) and the distribution of the protein was established by combined SEM micrographs and elemental mapping considering the casein-specific elements (P, N and S) not contained by the synthetic hydrogel matrix. The effect of casein on the mineralisation potential and stability of the mineral phase was investigated by FT-IR and SEM when alternating incubation in Ca/P solutions is performed. Increasing casein content in the hybrids leads to improved mineralisation, with localised formation of nanoapatite phase on the protein areas in the richest sample in protein. This behaviour was proved microstructurally by SEM and through overlapping elemental distribution of Ca and P from the newly formed mineral and P, S and N from the protein. This study indicates that nanoapatite-casein-PHEMA-PEGDA nanocomposites may be developed for potential use in bone repair and regeneration. Full article
(This article belongs to the Special Issue Carbon-Related Materials for Bioengineering)
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Review

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31 pages, 5358 KiB  
Review
Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications
by Elena Olăreț, Izabela-Cristina Stancu, Horia Iovu and Andrada Serafim
Materials 2021, 14(22), 6763; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14226763 - 10 Nov 2021
Cited by 7 | Viewed by 2705
Abstract
The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate [...] Read more.
The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds’ features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field. Full article
(This article belongs to the Special Issue Carbon-Related Materials for Bioengineering)
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