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Functional Materials in Biomedical Applications
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Functional Materials in Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4637

Special Issue Editor

Prof. Dr. Daniela Berger

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Guest Editor
Department Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania
Interests: drug-delivery systems; mesoporous materials; inorganic nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The accumulated knowledge in the field of materials science over the last two decades has allowed the design of new materials for various biomedical applications. Functional materials are designed to use their natural or engineered functionalities to interact appropriately with biological systems.

Thus, the aim of this Special Issue is to publish valuable papers, which advance the topics of functional materials for biomedical applications, such as drug-delivery systems, tissue engineering, biomimetic materials, implant materials, stimuli-responsive biosystems, matrices for encapsulation biological active compounds, and imaging nanosystems.

In the field of nanomaterials, where properties are dependent on particle size, biomedical applications are receiving increasing interest. Hence, papers dealing with the synthesis of nanostructured materials and properties are very welcome.

It is my pleasure to invite you to submit research papers, communications, or critical reviews within the scope of this Special Issue. I hope that this collection of papers will become a source of new ideas for the design of novel functional materials for future medicine.

Prof. Dr. Daniela Berger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug-delivery systems
  • surface functionalization
  • biomimetic materials
  • tissue engineering
  • functional composites
  • protein-base materials
  • stimuli-responsive biosystems
  • implant materials
  • imaging nanoparticles
  • magnetic nanoparticles

Published Papers (2 papers)

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Research

19 pages, 1946 KiB  
Article
Mesoporous Silica and Titania-Based Materials for Stability Enhancement of Polyphenols
by Mioara Prundeanu, Ana-Maria Brezoiu, Mihaela Deaconu, Gratiela Gradisteanu Pircalabioru, Daniel Lincu, Cristian Matei and Daniela Berger
Materials 2021, 14(21), 6457; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14216457 - 28 Oct 2021
Cited by 3 | Viewed by 1694
Abstract
To improve phytochemical stability, polyphenolic extracts prepared from Salvia officinalis L., which is a valuable source of phytocompounds with health benefits, were embedded into mesopores of silica, titania, or titania-ceria materials. Ethanolic and hydroalcoholic extracts were prepared by conventional, microwave- or ultrasound-assisted extraction. [...] Read more.
To improve phytochemical stability, polyphenolic extracts prepared from Salvia officinalis L., which is a valuable source of phytocompounds with health benefits, were embedded into mesopores of silica, titania, or titania-ceria materials. Ethanolic and hydroalcoholic extracts were prepared by conventional, microwave- or ultrasound-assisted extraction. The influence of the extraction conditions on chemical profile, radical scavenger activity (RSA), and antimicrobial potential of the extracts was assessed. The extracts were characterized by spectrophotometric determination of total polyphenols, flavonoids, chlorophyll pigment contents, as well as RSA. A reverse phase HPLC- PDA analysis was performed for the identification and quantification of extract polyphenols. The extract-loaded materials exhibited an enhanced RSA compared to the free extract after several months of storage, resulting in better polyphenol stability over time following embedding into a mesoporous matrix. Selected extracts free and embedded into mesoporous support were tested against Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, and Staphylococcus aureus ATCC 25923; the best antimicrobial activity was obtained for S. aureus. A slight improvement in antimicrobial activity was observed for the ethanolic extract prepared by ultrasound-assisted extraction following embedding into the TiO2 matrix compared to MCM-41 silica due to the support contribution. Full article
(This article belongs to the Special Issue Functional Materials in Biomedical Applications)
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15 pages, 2307 KiB  
Article
Ciprofloxacin-Releasing ROS-Sensitive Nanoparticles Composed of Poly(Ethylene Glycol)/Poly(D,L-lactide-co-glycolide) for Antibacterial Treatment
by Jaeik Song, Min-Suk Kook, Byung-Hoon Kim, Young-IL Jeong and Kyung-Jin Oh
Materials 2021, 14(15), 4125; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14154125 - 24 Jul 2021
Cited by 7 | Viewed by 2101
Abstract
Since urinary tract infections (UTIs) are closely associated with oxidative stress, we developed ROS-sensitive nanoparticles for ciprofloxacin (CIP) delivery for inhibition of UTI. Poly(D,L-lactide-co-glycolide) (PLGA)- selenocystamine (PLGA-selenocystamine) conjugates were attached to methoxypoly(ethylene glycol) (PEG) tetraacid (TA) (TA-PEG) conjugates to produce a copolymer (abbreviated [...] Read more.
Since urinary tract infections (UTIs) are closely associated with oxidative stress, we developed ROS-sensitive nanoparticles for ciprofloxacin (CIP) delivery for inhibition of UTI. Poly(D,L-lactide-co-glycolide) (PLGA)- selenocystamine (PLGA-selenocystamine) conjugates were attached to methoxypoly(ethylene glycol) (PEG) tetraacid (TA) (TA-PEG) conjugates to produce a copolymer (abbreviated as LGseseTAPEG). Selenocystamine linkages were introduced between PLGA and TA to endow reactive oxygen species (ROS) sensitivity to nanoparticles. CIP-incorporated nanoparticles of LGseseTAPEG copolymer were fabricated by W/O/W/W emulsion method. CIP-incorporated nanoparticles responded to H2O2 and then their morphologies were disintegrated by incubation with H2O2. Furthermore, particle size distribution of nanoparticles was changed from mono-modal distribution pattern to multi-modal distribution pattern by addition of H2O2. CIP release from nanoparticles of LGseseTAPEG copolymer was faster in the presence of H2O2 than in the absence of it. In antibacterial study using Escherichia coli (E. coli), free CIP and free CIP plus empty nanoparticles showed dose-dependent inhibitory effect against growth of bacteria while CIP-incorporated nanoparticles have less antibacterial activity compared to free CIP. These results were due to that CIP-incorporated nanoparticles have sustained release properties. When free CIP or CIP-incorporated nanoparticles were introduced into dialysis membrane to mimic in vivo situation, CIP-incorporated nanoparticles showed superior antibacterial activity compared to free CIP. At cell viability assay, nanoparticles of LGseseTAPEG copolymer have no acute cytotoxicity against L929 mouse fibroblast cells and CCD986sk human skin fibroblast cells. We suggest LGseseTAPEG nanoparticles are a promising candidate for CIP delivery. Full article
(This article belongs to the Special Issue Functional Materials in Biomedical Applications)
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