Special Issue "Polymer-Based Nanoparticles for Drug Delivery Applications"
Deadline for manuscript submissions: 30 November 2021.
2. iBB - Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal
Interests: drug delivery; nanomedicine; protein delivery; protein characterization; freeze-drying; biopharmaceutical; tissue engineering; wound healing; biomaterials; translational medicine
Special Issues and Collections in MDPI journals
Polymer nanoparticles are versatile carriers for the delivery of drugs through different delivery routes. This versatility turns them into excellent tools for the development of innovative drug delivery systems. In fact, they can deliver different types of drugs such as conventional drugs, proteins, and nucleic acids in a sustained, controlled, or targeted manner, while simultaneously protecting the stability of the loaded drug. In particular, active and passive targeting can improve the therapeutic effect of drugs and decrease their systemic toxicity, which is very important in the treatment of severe diseases such as cancer, autoimmune and inflammatory diseases, and others.
Polymers from natural (e.g., alginate, chitosan, cellulose, etc.) or synthetic (e. g. PLA, PLGA, PEG, etc.) sources can be used individually or combined to tailor-make polymer nanoparticles for drug delivery applications. Different production techniques such as solvent diffusion, solvent evaporation, nanoprecipitation, dialysis, spray-drying, and emulsification can be used to produce polymer-based nanoparticles. When focusing on drug delivery, the biocompatibility and toxicity of the delivery system are two important aspects to address.
Other strategies, like the combination with other materials or the use of polymers responsive to stimuli such as light, temperature, pH, electric field, are promising approaches to developing polymer-based nanoparticles for the delivery of drugs and the enhancement of the therapeutic outcome of therapies.
This Special Issue aims to provide an overview about the recent advances in the delivery of drugs using polymer-based nanoparticles, focusing on promising strategies for the improvement of therapies and of patients’ quality of life.
As the Guest Editor, I cordially invite all researchers to contribute original research articles or reviews on this important and exciting research field.
Dr. Pedro Fonte
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Polymer nanoparticle
- Drug delivery
- Protein delivery
- Nucleic acid
- Natural polymer
- Synthetic polymer
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Diflunisal Targeted Delivery Systems Based on Polymer Carriers: A Review
Authors: Petr Snetkov; Svetlana Morozkina; Roman Olekhnovich; Mayya Uspenskaya
Affiliation: ITMO University, Kronverkskiy Prospekt, 49A, 197101 Saint Petersburg, Russia
Abstract: Currently, there are a large number of rare diseases that require a personalized approach based not only on unique drugs, but also on systems for their targeted delivery. The amyloidosis, the main target of which is the heart, is only 4.5 cases per 100 thousand people. One of the recognized drugs for the treatment of cardiac amyloidosis is diflunisal, successfully used as nonsteroidal anti-inflammatory pharmaceutical agent. However, the clinical and practical use of diflunisal is mainly restricted by its poor solubility in water. The incorporation of diflunisal into polymer carriers is one of the possible methods to improve its solubility and stability, as well as to maintain the constant, controlled, and sustained drug release. In the present review the attention is given to recent development of diflunisal-loaded polymer nanocarriers, its technology, release profiles, and effectiveness.