Submit to Materials Review for Materials Propose a Special Issue

Journal Browser

► Journal Browser

Advances in Biomaterials towards Tissue Engineering

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 March 2023) | Viewed by 19791

Share This Special Issue

Special Issue Editors

Prof. Dr. Paweł Sajkiewicz

E-Mail Website
Guest Editor

Laboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research, the Polish Academy of Sciences, 02-106 Warsaw, Poland
Interests: biomaterials; polymers; nanofibers; electrospinning; tissue engineering; polymer–cell interactions
Special Issues, Collections and Topics in MDPI journals

Dr. Dorota Kolbuk-Konieczny

E-Mail Website
Guest Editor

Laboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research of the Polish Academy of Sciences, 02-106 Warsaw, Poland
Interests: biomaterials; polymers; titanium alloys; calcium phosfates; 3D printing; scaffolds

Special Issue Information

Dear Colleagues,

We have been asked by the Editor of Materials (MDPI) to be the Guest Editors of a Special Issue entitled "Advances in Biomaterials Towards Tissue Engineering".

There is still a fast-growing interest in the applications of biomaterials in the field of tissue engineering as well as drug delivery systems. A lot of effort has been made in recent years in the research of polymers, metals alloys, and ceramics dedicated to tissue engineering and sustained drug delivery systems. This Special Issue is focused on advances in biomaterial scaffolds formed by various techniques with potential in the aforementioned medical applications. Scaffolds’ morphology and chemical and molecular structure are crucial for material–cell interactions.

Considering your prominent contributions in this fascinating area, we would like to cordially invite you to submit a paper to this Special Issue, "Advances in Biomaterials Towards Tissue Engineering". through the journal webpage. The submitted manuscripts will then be fast-tracked for review. We would very much appreciate it if you could let us know of your interest in contributing a paper at your earliest convenience. Research articles and review articles, as well as communications and letters, are welcome.

Submitted manuscripts should not have been published previously nor be under consideration for publication elsewhere. All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submitting manuscripts is available on the journal’s website.

Prof. Dr. Paweł Sajkiewicz
Dr. Dorota Kolbuk-Konieczny
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

biomaterials
tissue engineering
scaffolds’ structure and morphology
polymers
titanium alloys
material–cell interactions

Published Papers (6 papers)

Download All Papers

Research

Jump to: Review

18 pages, 4962 KiB

Open AccessEditor’s ChoiceArticle

Novel Electrospun Polycaprolactone/Calcium Alginate Scaffolds for Skin Tissue Engineering

by Maria I. Echeverria Molina, Chi-An Chen, Jeniree Martinez, Perry Tran and Kyriakos Komvopoulos

Materials 2023, 16(1), 136; https://0-doi-org.brum.beds.ac.uk/10.3390/ma16010136 - 23 Dec 2022

Cited by 6 | Viewed by 1946

Abstract

After decades of research, fully functional skin regeneration is still a challenge. Skin is a multilayered complex organ exhibiting a cascading healing process affected by various mechanisms. Specifically, nutrients, oxygen, and biochemical signals can lead to specific cell behavior, ultimately conducive to the formation of high-quality tissue. This biomolecular exchange can be tuned through scaffold engineering, one of the leading fields in skin substitutes and equivalents. The principal objective of this investigation was the design, fabrication, and evaluation of a new class of three-dimensional fibrous scaffolds consisting of poly(ε-caprolactone) (PCL)/calcium alginate (CA), with the goal to induce keratinocyte differentiation through the action of calcium leaching. Scaffolds fabricated by electrospinning using a PCL/sodium alginate solution were treated by immersion in a calcium chloride solution to replace alginate-linked sodium ions by calcium ions. This treatment not only provided ion replacement, but also induced fiber crosslinking. The scaffold morphology was examined by scanning electron microscopy and systematically assessed by measurements of the pore size and the diameter, alignment, and crosslinking of the fibers. The hydrophilicity of the scaffolds was quantified by contact angle measurements and was correlated to the augmentation of cell attachment in the presence of CA. The in vitro performance of the scaffolds was investigated by seeding and staining fibroblasts and keratinocytes and using differentiation markers to detect the evolution of basal, spinous, and granular keratinocytes. The results of this study illuminate the potential of the PCL/CA scaffolds for tissue engineering and suggest that calcium leaching out from the scaffolds might have contributed to the development of a desirable biological environment for the attachment, proliferation, and differentiation of the main skin cells (i.e., fibroblasts and keratinocytes). Full article

(This article belongs to the Special Issue Advances in Biomaterials towards Tissue Engineering)

► Show Figures

Figure 1

15 pages, 6048 KiB

Open AccessArticle

Development of Wide-Angle Short-Wave Pass Thin Film Based on the Ultra-Thin Silicate Glass

by Xiuhua Fu, Suotao Dong, Shifu Xiong, Cheng Li and Xiaodong Chen

Materials 2022, 15(13), 4706; https://0-doi-org.brum.beds.ac.uk/10.3390/ma15134706 - 05 Jul 2022

Cited by 1 | Viewed by 1382

Abstract

With the rapid development of laser medicine, there are higher requirements placed on the performance of optical components in various medical systems. This paper is aimed at exploring the critical optical devices of medical equipment for treating periodontitis and gingivitis. The cathode sputtering method was used to produce the wide-angle short-wave pass filter, and a hundreds grid fastness test was conducted to detect the occurrence of film peeling. Considering the results of SEM, transmission spectrum, and stress test of the sample, an analysis was conducted as to the cause of poor bonding force for the film. By increasing the amount of argon gas and adjusting the baking temperature, the problem of film peeling was resolved. Besides, a short-wave pass filter film with good bonding and low roughness was obtained to meet the requirements of laser medical equipment. Full article

(This article belongs to the Special Issue Advances in Biomaterials towards Tissue Engineering)

► Show Figures

Figure 1

13 pages, 8871 KiB

Open AccessArticle

Crosslinking of Gelatin in Bicomponent Electrospun Fibers

by Judyta Dulnik and Paweł Sajkiewicz

Materials 2021, 14(12), 3391; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14123391 - 18 Jun 2021

Cited by 9 | Viewed by 2697

Abstract

Four chemical crosslinking methods were used in order to prevent gelatin leaching in an aqueous environment, from bicomponent polycaprolactone/gelatin (PCL/Gt) nanofibers electrospun from an alternative solvent system. A range of different concentrations and reaction times were employed to compare genipin, 1-(3-dimethylaminopropyl)-N’-ethylcarbodimide hydrochloride/N-hydroxysuccinimide (EDC/NHS), 1,4-butanediol diglycidyl ether (BDDGE), and transglutaminase. The objective was to optimize and find the most effective method in terms of reaction time and solution concentration, that at the same time provides satisfactory gelatin crosslinking degree and ensures good morphology of the fibers, even after 24 h in aqueous medium in 37 °C. The series of experiments demonstrated that, out of the four compared crosslinking methods, EDC/NHS was able to yield satisfactory results with the lowest concentrations and the shortest reaction times. Full article

(This article belongs to the Special Issue Advances in Biomaterials towards Tissue Engineering)

► Show Figures

Figure 1

18 pages, 6750 KiB

Open AccessArticle

Solution Blow Spinning of Polycaprolactone—Rheological Determination of Spinnability and the Effect of Processing Conditions on Fiber Diameter and Alignment

by Katarzyna Czarnecka, Michał Wojasiński, Tomasz Ciach and Pawel Sajkiewicz

Materials 2021, 14(6), 1463; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14061463 - 17 Mar 2021

Cited by 19 | Viewed by 3598

Abstract

The growing popularity of solution blow spinning as a method for the production of fibrous tissue engineering scaffolds and the vast range of polymer–solvent systems available for the method raises the need to study the effect of processing conditions on fiber morphology and develop a method for its qualitative assessment. Rheological approaches to determine polymer solution spinnability and image analysis approaches to describe fiber diameter and alignment have been previously proposed, although in a separate manner and mostly for the widely known, well-researched electrospinning method. In this study, a series of methods is presented to determine the processing conditions for the development of submicron fibrous scaffolds. Rheological methods are completed with extensive image analysis to determine the spinnability window for a polymer–solvent system and qualitatively establish the influence of polymer solution concentration and collector rotational speed on fiber morphology, diameter, and alignment. Process parameter selection for a tissue engineering scaffold target application is discussed, considering the varying structural properties of the native extracellular matrix of the tissue of interest. Full article

(This article belongs to the Special Issue Advances in Biomaterials towards Tissue Engineering)

► Show Figures

Figure 1

18 pages, 9823 KiB

Open AccessArticle

Bone Density Micro-CT Assessment during Embedding of the Innovative Multi-Spiked Connecting Scaffold in Periarticular Bone to Elaborate a Validated Numerical Model for Designing Biomimetic Fixation of Resurfacing Endoprostheses

by Ryszard Uklejewski, Mariusz Winiecki, Adam Patalas and Piotr Rogala

Materials 2021, 14(6), 1384; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14061384 - 12 Mar 2021

Cited by 6 | Viewed by 2788

Abstract

Our team has been working for some time on designing a new kind of biomimetic fixation of resurfacing endoprostheses, in which the innovative multi-spiked connecting scaffold (MSC-Scaffold) that mimics the natural interface between articular cartilage and periarticular trabecular bone in human joints is the crucial element. This work aimed to develop a numerical model enabling the design of the considered joint replacement implant that would reflect the mechanics of interacting biomaterials. Thus, quantitative micro-CT analysis of density distribution in bone material during the embedding of MSC-Scaffold in periarticular bone was applied. The performed numerical studies and corresponding mechanical tests revealed, under the embedded MSC-Scaffold, the bone material densification affecting its mechanical properties. On the basis of these findings, the built numerical model was modified by applying a simulated insert of densified bone material. This modification led to a strong correlation between the re-simulation and experimental results (FVU = 0.02). The biomimetism of the MSC-Scaffold prototype that provided physiological load transfer from implant to bone was confirmed based on the Huber–von Mises–Hencky (HMH) stress maps obtained with the validated finite element (FE) model of the problem. The micro-CT bone density assessment performed during the embedding of the MSC-Scaffold prototype in periarticular bone provides insight into the mechanical behaviour of the investigated implant-bone system and validates the numerical model that can be used for the design of material and geometric features of a new kind of resurfacing endoprostheses fixation. Full article

(This article belongs to the Special Issue Advances in Biomaterials towards Tissue Engineering)

► Show Figures

Figure 1

Review

Jump to: Research

28 pages, 2656 KiB

Open AccessReview

Advances in 3D Printing for Tissue Engineering

by Angelika Zaszczyńska, Maryla Moczulska-Heljak, Arkadiusz Gradys and Paweł Sajkiewicz

Materials 2021, 14(12), 3149; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14123149 - 08 Jun 2021

Cited by 50 | Viewed by 6132

Abstract

Tissue engineering (TE) scaffolds have enormous significance for the possibility of regeneration of complex tissue structures or even whole organs. Three-dimensional (3D) printing techniques allow fabricating TE scaffolds, having an extremely complex structure, in a repeatable and precise manner. Moreover, they enable the easy application of computer-assisted methods to TE scaffold design. The latest additive manufacturing techniques open up opportunities not otherwise available. This study aimed to summarize the state-of-art field of 3D printing techniques in applications for tissue engineering with a focus on the latest advancements. The following topics are discussed: systematics of the available 3D printing techniques applied for TE scaffold fabrication; overview of 3D printable biomaterials and advancements in 3D-printing-assisted tissue engineering. Full article

(This article belongs to the Special Issue Advances in Biomaterials towards Tissue Engineering)

► Show Figures