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Bone Graft Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 5123

Special Issue Editor


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Guest Editor
Division of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, Hanyang University, Seoul, Korea
Interests: bone graft materials; dental implants; guided bone regeneration; sinus floor augmentation

Special Issue Information

Dear Colleagues,

In the field of orthopedic, craniofacial, and oral surgery, bone grafting is a surgical reconstructive procedure to compensate for the lack of horizontal and/or vertical bone using various bone grafting materials, such as autografts, allografts, alloplastics, and xenografts, frequently with implant insertions. Moreover, many bioacative proteins, such as bone morphogenetic proteins and platelet-derived growth factors, are also widely used to rehabilitate the osseous defects for cosmetic and functional purposes.

The purpose of this Special Issue, “Bone Graft Materials”, is structured by the aim to sum up recent promising progresses in bone graft materials, including updated findings, new production methods, and the latest biomaterials and their delivery techniques for patient- and surgeon-friendly approaches. This Special Issue, “Bone Graft Materials”, is also open to biocompatible osteoconductive polymers, bone fillers, barrier membranes, and bio-printings.

Prof. Dr. Chang-Joo Park
Guest Editor

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Keywords

  • allografts
  • autografts
  • bone grafting
  • bone morphogenetic proteins
  • guided bone regeneration
  • implants
  • polymers
  • sinus floor augmentation
  • spinal fusion
  • synthetic bone graft
  • xenografts

Published Papers (2 papers)

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16 pages, 17339 KiB  
Article
Physico-Chemical Characteristics and Posterolateral Fusion Performance of Biphasic Calcium Phosphate with Submicron Needle-Shaped Surface Topography Combined with a Novel Polymer Binder
by Ruggero Belluomo, Inazio Arriola-Alvarez, Nathan W. Kucko, William R. Walsh, Joost D. de Bruijn, Rema A. Oliver, Dan Wills, James Crowley, Tian Wang and Florence Barrère-de Groot
Materials 2022, 15(4), 1346; https://0-doi-org.brum.beds.ac.uk/10.3390/ma15041346 - 11 Feb 2022
Cited by 3 | Viewed by 2824
Abstract
A biphasic calcium phosphate with submicron needle-shaped surface topography combined with a novel polyethylene glycol/polylactic acid triblock copolymer binder (BCP-EP) was investigated in this study. This study aims to evaluate the composition, degradation mechanism and bioactivity of BCP-EP in vitro, and its in [...] Read more.
A biphasic calcium phosphate with submicron needle-shaped surface topography combined with a novel polyethylene glycol/polylactic acid triblock copolymer binder (BCP-EP) was investigated in this study. This study aims to evaluate the composition, degradation mechanism and bioactivity of BCP-EP in vitro, and its in vivo performance as an autograft bone graft (ABG) extender in a rabbit Posterolateral Fusion (PLF) model. The characterization of BCP-EP and its in vitro degradation products showed that the binder hydrolyses rapidly into lactic acid, lactide oligomers and unaltered PEG (polyethylene glycol) without altering the BCP granules and their characteristic submicron needle-shaped surface topography. The bioactivity of BCP-EP after immersion in SBF revealed a progressive surface mineralization. In vivo, BCP-EP was assessed in a rabbit PLF model by radiography, manual palpation, histology and histomorphometry up to 12 weeks post-implantation. Twenty skeletally mature New Zealand (NZ) White Rabbits underwent single-level intertransverse process PLF surgery at L4/5 using (1) autologous bone graft (ABG) alone or (2) by mixing in a 1:1 ratio with BCP-EP (BCP-EP/ABG). After 3 days of implantation, histology showed the BCP granules were in direct contact with tissues and cells. After 12 weeks, material resorption and mature bone formation were observed, which resulted in solid fusion between the two transverse processes, following all assessment methods. BCP-EP/ABG showed comparable fusion rates with ABG at 12 weeks, and no graft migration or adverse reaction were noted at the implantation site nor in distant organs. Full article
(This article belongs to the Special Issue Bone Graft Materials)
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7 pages, 1749 KiB  
Case Report
Dentin-Derived-Barrier Membrane in Guided Bone Regeneration: A Case Report
by Jeong-Kui Ku, In-Woong Um, Mi-Kyoung Jun and Il-hyung Kim
Materials 2021, 14(9), 2166; https://doi.org/10.3390/ma14092166 - 23 Apr 2021
Cited by 6 | Viewed by 1655
Abstract
An autogenous, demineralized, dentin matrix is a well-known osteo-inductive bone substitute that is mostly composed of type I collagen and is widely used in implant dentistry. This single case report describes a successful outcome in guided bone regeneration and dental implantation with a [...] Read more.
An autogenous, demineralized, dentin matrix is a well-known osteo-inductive bone substitute that is mostly composed of type I collagen and is widely used in implant dentistry. This single case report describes a successful outcome in guided bone regeneration and dental implantation with a novel human-derived collagen membrane. The authors fabricated a dentin-derived-barrier membrane from a block-type autogenous demineralized dentin matrix to overcome the mechanical instability of the collagen membrane. The dentin-derived-barrier acted as an osteo-inductive collagen membrane with mechanical and clot stabilities, and it replaced the osteo-genetic function of the periosteum. Further research involving large numbers of patients should be conducted to evaluate bone forming capacity in comparison with other collagen membranes. Full article
(This article belongs to the Special Issue Bone Graft Materials)
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