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Novel Fluorescent Materials and Nanomaterials for Biomedical Applications
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Novel Fluorescent Materials and Nanomaterials for Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 3227

Special Issue Editor

Dr. Dokyoung Kim

E-Mail Website
Guest Editor
Department of Biomedical Sciences, Graduate School, Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul, Korea
Interests: innovating chemical tools design for disease diagnosis and bioimaging; innovating novel nanoformulations for drug delivery systems; biomarker sensing materials and platform; fluorescent materials; porous silicon materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to introduce a new Special Issue, titled “Novel Fluorescent Materials and Nanomaterials for Biomedical Applications” which will be published in Materials, an interdisciplinary journal dedicated to covering leading research and developments in the field of materials science and engineering. This Special Issue encompasses the field of fluorescent materials and nanomaterials for biomedical applications based on organic/inorganic/nano/hybrid materials. Potential topics include, but are not limited to, the following: fluorescent materials; fluorescent probes/sensors; fluorescent nanomaterials; fluorophores; bio-imaging materials; sensing probes; near-infrared emitting materials; aggregation-induced emission materials; one-/two-photon excitable probes; fluorescent detection and sensing; biomarker sensing; drug-delivery system; image-guided surgery; optical imaging; biomedical applications.

Please consider this invitation to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Prof. Dokyoung Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescent materials
  • fluorescent nanomaterials
  • bio-imaging
  • biomarker sensing
  • sensing platform
  • drug-delivery system
  • translational medicine
  • nanomedicine

Published Papers (1 paper)

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Research

24 pages, 6732 KiB  
Article
Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application
by Adriana Trapani, Filomena Corbo, Gennaro Agrimi, Nicoletta Ditaranto, Nicola Cioffi, Filippo Perna, Andrea Quivelli, Erika Stefàno, Paola Lunetti, Antonella Muscella, Santo Marsigliante, Antonio Cricenti, Marco Luce, Cristina Mormile, Antonino Cataldo and Stefano Bellucci
Materials 2021, 14(13), 3495; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14133495 - 23 Jun 2021
Cited by 15 | Viewed by 2677
Abstract
Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, [...] Read more.
Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, the aim of this work is the synthesis and preliminary characterization of an oxidized alginate-dopamine (AlgOX-DA) conjugate conceived for DA nose-to-brain delivery. Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and 1H- NMR spectroscopies, as well as in vitro mucoadhesive and release tests. Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration. Full article
(This article belongs to the Special Issue Novel Fluorescent Materials and Nanomaterials for Biomedical Applications)
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