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Novel Hybrid Hydrogels for Bone Tissue Engineering Applications
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Novel Hybrid Hydrogels for Bone Tissue Engineering Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 April 2023) | Viewed by 11035

Special Issue Editor

Dr. Anuj Kumar

E-Mail Website
Guest Editor
School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Korea
Interests: polymer chemistry; sustainable materials; biocomposites; biomaterials, nanocellulose, hydrogels; tissue engineering; cancer therapeutics; 3D printing/bioprinting; bioelectronics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Orthopedic injuries always have been an area of concern in the field of medicine and healthcare, where large bone defects, fractures, infections, and tumor resections are some serious problems in bone surgeries. Therefore, bone grafting has been performed widely to enhance repair of bone tissues, but engineering of bone tissues by using artificial supports is considered a potential alternative approach to bone grafting due to its good supply and no transmission of disease. However, there are also several challenges and limitations for successful clinical translation. Bone tissue regeneration involves three main components together: the scaffold, cells, and growth factors/signaling molecules. Additionally, successful cell-fate depends mainly on scaffold material properties and architecture, including required dynamic mechanical properties. But, the fabrication of an appropriate scaffold (i.e., extracellular microenvironment) with precise control over the desired properties is also a great challenge for mimicking 3D microenvironment of bone tissue. Therefore, this research field requires an interdisciplinary approach for proper understanding of native bone tissues, materials, processing/fabrication technologies, and thereby to obtain desired supporting matrices.  

As natural bone is a nanocomposite of organic and inorganic components, various artificial and biomimetic scaffolds have been manufactured by using conventional to advanced processing techniques, but has not succeeded well due to lack of sufficient and timely vascularization of the scaffold for optimal bone tissue formation and integration. In this advancement, hydrogels as soft and highly hydrated polymeric-networks are considered to be more suitable and effective artificial supportive matrix resembling those of native tissues to some extent. However, their poor mechanical properties limit their applicability in this field. In the past few decades, tremendous advances in hydrogels have been reported in this research field to induce cell adhesion, growth, and differentiation, and thereby new tissue formation. Nevertheless, various challenges in structure-property-relationships (e.g., mechanical and biological responses) still remain to be overcome for suitable clinical translation.  

This Special Issue focuses on various aspects of novel hybrid hydrogels, including material synthesis, design process of new compositions, fabrication methods, and biological responses in vitro and in vivo for bone tissue regeneration. Therefore, the objective of this Special Issue is to provide current advances, limitations, future perspective and research directions for new developments in organic and inorganic materials, ease of processing and techniques, and their successful application in bone tissue engineering. It is our pleasure to invite you to submit a manuscript, including original research and review articles on (but not limited to) the following potential themes:

  1. Biomaterials and nanomaterials for hybrid hydrogels
  2. Design process of hybrid hydrogels for bone tissue regeneration
  3. Preparation of polymer/hydroxyapatite-based hybrid hydrogels
  4. Preparation of polymer/bioceramic-based hybrid hydrogels
  5. Preparation of polymer/bioactive glass-based hybrid hydrogels
  6. Injectable hybrid hydrogels
  7. Bioresponsive hybrid hydrogels
  8. Self-assembled hybrid hydrogels
  9. Self-healing hybrid hydrogels
  10. Antimicrobial/antibacterial hybrid hydrogels
  11. Additive manufacturing of hybrid hydrogels
  12. 3D printing/bioprinting and hybrid hydrogels

Dr. Anuj Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • biomaterials
  • bioceramics
  • bioactive glasses
  • hydroxyapatite
  • piezoelectric materials
  • nanocomposites
  • antibacterial materials
  • additive manufacturing
  • 3D printing/bioprinting
  • bone tissue engineering

Published Papers (2 papers)

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Review

19 pages, 3931 KiB  
Review
Enzyme-Triggered Crosslinked Hybrid Hydrogels for Bone Tissue Engineering
by Ankur Sood, Seong Min Ji, Anuj Kumar and Sung Soo Han
Materials 2022, 15(18), 6383; https://0-doi-org.brum.beds.ac.uk/10.3390/ma15186383 - 14 Sep 2022
Cited by 11 | Viewed by 2098
Abstract
The quest to develop state-of-the-art hydrogels for bone tissue engineering has accompanied substantial innovation and significant progression in the field of bioactive hydrogels. Still, there is scope for advancement in this cell-friendly and biocompatible scaffold system. The crosslinking approaches used for hydrogel synthesis [...] Read more.
The quest to develop state-of-the-art hydrogels for bone tissue engineering has accompanied substantial innovation and significant progression in the field of bioactive hydrogels. Still, there is scope for advancement in this cell-friendly and biocompatible scaffold system. The crosslinking approaches used for hydrogel synthesis plays a decisive role in guiding and regulating the mechanical stability, network framework, macroscopic architect, immunological behaviors, and cellular responses. Until recently, enzyme-based crosslinking strategies were considered as the pinnacle in designing efficient hybrid hydrogel systems. A variety of enzymes have been explored for manufacturing hydrogels while taking the advantage of the biocompatible nature, specificity, ability to produce nontoxic by products and high efficiency of enzymes. The current review focuses on the utility of different enzymes as crosslinking agents for hydrogel formation with their application in bone tissue engineering. The field of enzyme crosslinked hydrogel synthesis is rapidly maturing with a lot of opportunities to be explored in bone tissue engineering. Enzyme-based in situ and externally crosslinked hydrogels for bone regeneration is an attractive field, and with innovation in using engineered enzymes this field will continue to flourish with clinical orientation. Full article
(This article belongs to the Special Issue Novel Hybrid Hydrogels for Bone Tissue Engineering Applications)
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16 pages, 2562 KiB  
Review
Mechanical Properties of Compact Bone Defined by the Stress-Strain Curve Measured Using Uniaxial Tensile Test: A Concise Review and Practical Guide
by Che-Yu Lin and Jiunn-Horng Kang
Materials 2021, 14(15), 4224; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14154224 - 28 Jul 2021
Cited by 25 | Viewed by 8015
Abstract
Mechanical properties are crucial parameters for scaffold design for bone tissue engineering; therefore, it is important to understand the definitions of the mechanical properties of bones and relevant analysis methods, such that tissue engineers can use this information to properly design the mechanical [...] Read more.
Mechanical properties are crucial parameters for scaffold design for bone tissue engineering; therefore, it is important to understand the definitions of the mechanical properties of bones and relevant analysis methods, such that tissue engineers can use this information to properly design the mechanical properties of scaffolds for bone tissue engineering. The main purpose of this article is to provide a review and practical guide to understand and analyze the mechanical properties of compact bone that can be defined and extracted from the stress–strain curve measured using uniaxial tensile test until failure. The typical stress–strain curve of compact bone measured using uniaxial tensile test until failure is a bilinear, monotonically increasing curve. The associated mechanical properties can be obtained by analyzing this bilinear stress–strain curve. In this article, a computer programming code for analyzing the bilinear stress–strain curve of compact bone for quantifying the associated mechanical properties is provided, such that the readers can use this computer code to perform the analysis directly. In addition to being applied to compact bone, the information provided by this article can also be applied to quantify the mechanical properties of any material having a bilinear stress–strain curve, such as a whole bone, some metals and biomaterials. The information provided by this article can be applied by tissue engineers, such that they can have a reference to properly design the mechanical properties of scaffolds for bone tissue engineering. The information can also be applied by researchers in biomechanics and orthopedics to compare the mechanical properties of bones in different physiological or pathological conditions. Full article
(This article belongs to the Special Issue Novel Hybrid Hydrogels for Bone Tissue Engineering Applications)
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