Recent Advances in Tooth Repair and Regeneration

Dear Colleagues,

Dental caries is one of the most prevalent chronic diseases in the world, and approximately 35% of the world's population has untreated caries in their permanent dentition. The World Health Organization's "Millennium Development Goals" for general and oral health call for treatments that control pain and infection, are non-invasive, require minimal application time and training, and use affordable and easy-to-use materials. In this context, the use of simple techniques to improve access to low-cost oral care is a major necessity.

The understanding of the pathological demineralization of enamel and dentin as a dynamic process evolving towards demineralization or re-mineralization has led to the possibility of new therapies encouraging both the remineralization of lesions and maximum preservation of the dental substrate (i.e., minimal invasiveness). There is growing research evidence suggesting that demineralized enamel and dentin can be biomodified at the mineral and organic level by simple and cost-effective means to achieve mineralization.

The Special Issue "Recent Advances in Tooth Repair and Regeneration" calls for contributions from scientists on innovative approaches for enamel and dentin regeneration and repair. Dental materials favoring bioactivity or with distinct properties against caries progression are also within the scope of this Issue. Topics may include the use of cross-linkers, antibacterial monomers, hydroxyapatite–collagen scaffolds, calcium phosphate compounds, self-assembling peptides, ion-releasing materials, bioactive glasses, and plant-derived materials, among others. It is the purpose of this Special Issue to present advances in dental materials and research techniques that may soon be translated into clinical applications, so that new cost-effective therapeutic approaches for the management of carious lesions become available for the benefit of patients.

Dr. Tissiana Bortolotto
Guest Editor

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• bioactivity
• enamel repair
• dentin repair
• mineralization
• caries arrest