Update on Acute and Chronic Wound Healing

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 10888

Special Issue Editors

Institut of Applied Bio-Sciences and Process Management, Anhalt University of Applied Sciences, D-06366 Kothen, Germany
Interests: acute and chronic wound healing; wound diagnostics; outcome research
1. Faculty of Medicine, “Grigore T Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania
2. Clinic of Plastic Surgery and Reconstructive Microsurgery, "Sf Spiridon" Emergency County Hospital, 700111 Iasi, Romania
Interests: plastic surgery; reconstructive surgery; microsurgery; burns; hand surgery; nerve surgery

Special Issue Information

Dear Colleagues,

Wound healing after damage to the skin involves a complex interplay between many cellular players of the skin, primarily keratinocytes, fibroblasts, and endothelial cells of vessels, as well as recruited immune cells and their associated extracellular matrix. In healthy individuals, the restoration of a functional epidermal barrier is highly efficient, whereas repair of the deeper dermal layer is less perfect and often results in scar formation with a substantial loss of original tissue structure and function. When the normal wound repair process is impaired, impaired wound healing can lead to chronic wounds or to excessive formation of scar tissue.

Tissue repair is a universal phenomenon across all multicellular organisms, and we think that many wound healing mechanisms can be analyzed in more experimentally tractable models than humans, and can be subsequently extrapolated back to the clinic for potential therapeutic benefits. Because of similarities to humans, in vivo and ex vivo wound healing models are used for investigating repair mechanisms. The aim of this Special Issue to give an update basic, translational, and clinical research related acute and chronic wound healing.

Prof. Dr. Lars P. Kamolz
Dr. Thomas Wild
Dr. Mihaela Pertea
Guest Editors

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Keywords

  • wound healing
  • in vitro, ex vivo, in vivo models
  • biomarker research
  • chronic wounds
  • scars

Published Papers (3 papers)

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Research

11 pages, 851 KiB  
Article
Effect of Combined Electromagnetic Field and Plantar Flexion Resistance Exercise on Wound Healing in Patients with Venous Leg Ulcers: A Randomized Controlled Trial
by Heba Mohamed Mohamady, Mona Mohamed Taha, Yasser M. Aneis, Monira I. Aldhahi and Asmaa Fawzy Attalla
Medicina 2023, 59(6), 1157; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina59061157 - 15 Jun 2023
Cited by 2 | Viewed by 1739
Abstract
Background and Objectives: Venous ulcers are recognized to be more painful and resistant to therapy than ulcers of other etiologies. Various methods have been used for the conservative treatment of venous ulcers, such as pulsed electromagnetic field (PEMF) and plantar exercise, which [...] Read more.
Background and Objectives: Venous ulcers are recognized to be more painful and resistant to therapy than ulcers of other etiologies. Various methods have been used for the conservative treatment of venous ulcers, such as pulsed electromagnetic field (PEMF) and plantar exercise, which promote wound healing due to a range of physiological effects. The study aimed to examine the effect of combined pulsed electromagnetic field therapy and plantar flexion resistance exercise (PRE) on patients with venous leg ulcers (VLUs). Materials and Methods: The study was a prospective, randomized controlled trial. A total of 60 patients between the ages of 40 and 55 with venous ulcers were randomly assigned to 1 of 3 groups. For up to 12 weeks, the first group received PEMF therapy and plantar flexion resistance exercise (PRE) therapy in addition to conservative ulcer treatment for up to 12 weeks. The second group received only PEMF therapy in addition to conservative ulcer treatment, while the third group served as the control and received only conservative ulcer treatment. Results: At the four-week follow-up, the two experimental groups revealed a considerable variation in ulcer surface area (USA) and ulcer volume (UV), with no significant change in the control group. At the 12-week follow-up, there were significant differences between the three groups, while group A underwent the most significant changes, with mean differences at [95% confidence interval] of (−4.75, −3.82, −0.98) for USA and (−12.63, −9.55, −2.45) for UV, respectively. Conclusions: On a short-term basis, adding a plantar resistance exercise to the PEMF had no appreciable short-term effects on ulcer healing; however, their combination had more pronounced medium-term effects. Full article
(This article belongs to the Special Issue Update on Acute and Chronic Wound Healing)
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12 pages, 27918 KiB  
Article
Comparison of Long-Term Skin Quality and Scar Formation in Partial-Thickness Burn Wounds Treated with Suprathel® and epicitehydro® Wound Dressings
by Jennifer Lynn Schiefer, Friederike Genoveva Aretz, Paul Christian Fuchs, Rolf Lefering, Pouyan Yary, Christian Opländer, Alexandra Schulz and Marc Daniels
Medicina 2022, 58(11), 1550; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58111550 - 28 Oct 2022
Cited by 1 | Viewed by 1995
Abstract
Background and Objectives: Scar formation after burn trauma has a significant impact on the quality of life of burn patients. Hypertrophic scars or keloids can be very distressing to patients due to potential pain, functional limitations, or hyper- or hypopigmentation. In a [...] Read more.
Background and Objectives: Scar formation after burn trauma has a significant impact on the quality of life of burn patients. Hypertrophic scars or keloids can be very distressing to patients due to potential pain, functional limitations, or hyper- or hypopigmentation. In a previous study comparing Suprathel® and the new and cheaper dressing epicitehydro®, we were able to show that pain reduction, exudation, and time until wound-healing of partial-thickness burn wounds were similar, without any documented infections. No study exists that objectively measures and compares skin and scar quality after treatment with Suprathel® and epicitehydro® at present. Materials and Methods: In this study, the scar quality of 20 patients who had been treated with Suprathel® and epicitehydro® was objectively assessed using the Cutometer®, Mexameter®, and Tewameter®, as well as subjectively with the Patient and Observer Scar Assessment Scale, 3, 6, and 12 months after burn injury. Results: In all performed measurements, no significant differences were detected in scar formation after treatment of partial-thickness burn wounds with the two dressings. Conclusions: Both the newer and less expensive wound-dressing epicitehydro® and the well-known wound-dressing Suprathel® resulted in stable wound closure and showed good cosmetic results in the follow-up examinations. Full article
(This article belongs to the Special Issue Update on Acute and Chronic Wound Healing)
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15 pages, 3597 KiB  
Article
Contribution of Topical Agents such as Hyaluronic Acid and Silver Sulfadiazine to Wound Healing and Management of Bacterial Biofilm
by Francesco De Francesco, Michele Riccio and Shiro Jimi
Medicina 2022, 58(6), 835; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58060835 - 20 Jun 2022
Cited by 13 | Viewed by 5621
Abstract
Background and Objectives: Wound healing is commonly associated with critical bacterial colonization or bacterial infection, which induces prolonged inflammation, resulting in delayed re-epithelialization. An appropriate wound dressing requires a humid environment, which also functions as a barrier against bacterial contamination and will accelerate [...] Read more.
Background and Objectives: Wound healing is commonly associated with critical bacterial colonization or bacterial infection, which induces prolonged inflammation, resulting in delayed re-epithelialization. An appropriate wound dressing requires a humid environment, which also functions as a barrier against bacterial contamination and will accelerate a regenerative response of the wound. Silver sulfadiazine (SSD) is used to prevent wound infection. Hyaluronic acid (HA) is an extracellular matrix component involved in tissue regeneration. This retrospective study was conducted to evaluate the effectiveness of cream and gauze pads based on hyaluronic acid at low molecular weight (200 kDa) and silver sulfadiazine 1% in the wound healing process. In addition, we examined SSD action on biofilms in vitro and on animal wounds, obtaining positive outcomes therefrom. Materials and Methods: We selected 80 patients with complicated chronic wounds of different etiologies, including diabetes mellitus (10), post-traumatic ulcers (45), burns (15), and superficial abrasion (10). Results: After 8 weeks, ulcer size was decreased in 95 ± 2% of the treated patients; a significant reduction in the inflammatory process was observed from day 14 onwards (p < 0.01 vs. baseline), considering improvement of the surrounding skin and reduction of the bacterial load. The SSD treatment decreased bacterial colony proliferation, both in planktonic state and in biofilm, in a dose-dependent manner on the wound but inhibited the development of tissue granulation at the highest dose (800 μg/wound). Conclusions: In conclusion, the combined action of SSD and HA is clinically effective in improving wound healing. Full article
(This article belongs to the Special Issue Update on Acute and Chronic Wound Healing)
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