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Medicina
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Current Trends in the Management of Gastroesophageal Reflux Disease (GERD),...
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Current Trends in the Management of Gastroesophageal Reflux Disease (GERD), Obesity, and Bariatric Surgery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: closed (1 July 2021) | Viewed by 8367

Special Issue Editors

Dr. Marius Nedelcu

E-Mail Website
Guest Editor
1. Department of General Surgery, Clinique Bouchard, ELSAN, 13006 Marseille, France
2. Department of General Surgery, Centre Chirurgical de l'Obesite, ELSAN, Clinique Saint Michel, Avenue de l'Orient, 83100 Toulon, France
Interests: bariatric surgery; metabolic surgery; gastroesophageal reflux disease
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. David Nocca

E-Mail Website
Co-Guest Editor
Service de Chirurgie Digestive A, Hôpital Saint Eloi, CHU de Montpellier, 34295 Montpellier, France
Interests: bariatric surgery; Nissen sleeve gastrectomy
Special Issues, Collections and Topics in MDPI journals
Dr. Mariano Palermo

E-Mail Website
Co-Guest Editor
Division of bariatric surgery of DIAGNOMED, Affiliated institution of the University of Buenos Aires, Buenos Aires, Argentina
Interests: bariatric surgery; metabolic surgery; percutaneous surgery
Prof. Dr. Ramon Vilallonga

E-Mail Website
Co-Guest Editor
Endocrine, metabolic and bariatric Unit, General Surgery Department, Hospital Vall d'Hebron, Barcelona, Spain
Interests: bariatric and endocrine surgery; reflux

Special Issue Information

Dear Colleagues,

The association between obesity and GERD is very well known, even though the pathophysiology of GERD is not completely understood and is likely to have a multifactorial nature. Bariatric surgery is the only effective treatment for morbid obesity and obtains the best long-term outcomes. Each bariatric procedure (restrictive or malabsorptive) is associated with a different balance of risks and benefits, in terms of surgical complications, excess weight loss, and resolution of GERD. The effect of bariatric surgery on preexisting GERD, or newly developed GERD, is still controversial, and measuring GERD is a difficult task. Endoscopy represents a tool in the first line to characterize GERD evolution before and after bariatric surgery.

Although bariatric surgery has been successfully performed for several decades, the mechanism of action of each type of procedure is not completely understood both for weight loss and GERD remission or de novo GERD. The current editorial summarizes the principal mechanisms involved in GERD for different new bariatric procedures (Nissen sleeve, BariClip or Endoscopic Sleeve Gastroplasty). For those with moderate reflux, since specific procedure guidelines are missing, surgical treatment for morbidly obese patients must be selected according to the clinical characteristics of the patient, their eating habits, and patient willingness. It should be based on a preoperative work-up with shared decision making, with the double purpose of treating both GERD and obesity.

Dr. Marius Nedelcu
Prof. Dr. David Nocca
Dr. Mariano Palermo
Prof. Dr. Ramon Vilallonga
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Gastroesophageal reflux disease
  • Morbid obesity disease
  • Endoscopic findings
  • Endoscopic sleeve gastroplasty
  • Nissen sleeve
  • BariClip

Published Papers (3 papers)

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Review

7 pages, 278 KiB  
Review
The Effect of Endoscopic Bariatric and Metabolic Therapies on Gastroesophageal Reflux Disease
by Su-Young Kim
Medicina 2021, 57(8), 737; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57080737 - 21 Jul 2021
Cited by 2 | Viewed by 1661
Abstract
Obesity is a chronic disease that is becoming increasingly more prevalent and is associated with many health problems, such as metabolic syndrome. The treatment options for obese patients include lifestyle modification, medications, endoscopic bariatric and metabolic therapies (EBMTs), and surgery. In particular, EBMTs [...] Read more.
Obesity is a chronic disease that is becoming increasingly more prevalent and is associated with many health problems, such as metabolic syndrome. The treatment options for obese patients include lifestyle modification, medications, endoscopic bariatric and metabolic therapies (EBMTs), and surgery. In particular, EBMTs have an excellent therapeutic effect and are less invasive than bariatric surgery. Although it is clear that EBMTs are relatively safe procedures, they can result in several adverse events. Among them, the relationship between EBMTs and gastroesophageal reflux disease (GERD) is unclear. Several studies have demonstrated that an intragastric balloon (IGB) may worsen GERD. There are a few studies on the effects of endoscopic sleeve gastroplasty (ESG) on GERD, but the linking evidence is insufficient. However, the conclusion is not simple. Because obesity is an important cause of GERD, and GERD naturally improves with weight loss after EBMTs, it is not easy to evaluate accurately the effect of EBMTs on GERD. This review aimed to discuss the effect of EBMTs on GERD and suggest future research directions. Full article
(This article belongs to the Special Issue Current Trends in the Management of Gastroesophageal Reflux Disease (GERD), Obesity, and Bariatric Surgery)
9 pages, 290 KiB  
Review
GERD after Bariatric Surgery. Can We Expect Endoscopic Findings?
by Ramon Vilallonga, Sergi Sanchez-Cordero, Nicolas Umpiérrez Mayor, Alicia Molina, Arturo Cirera de Tudela, Elena Ruiz-Úcar and Manel Armengol Carrasco
Medicina 2021, 57(5), 506; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57050506 - 17 May 2021
Cited by 8 | Viewed by 2907
Abstract
Background and Objectives: Bariatric surgery remains the gold standard treatment for morbidly obese patients. Roux-en-y gastric bypass and laparoscopic sleeve gastrectomy are the most frequently performed surgeries worldwide. Obesity has also been related to gastroesophageal reflux disease (GERD). The management of a [...] Read more.
Background and Objectives: Bariatric surgery remains the gold standard treatment for morbidly obese patients. Roux-en-y gastric bypass and laparoscopic sleeve gastrectomy are the most frequently performed surgeries worldwide. Obesity has also been related to gastroesophageal reflux disease (GERD). The management of a preoperative diagnosis of GERD, with/without hiatal hernia before bariatric surgery, is mandatory. Endoscopy can show abnormal findings that might influence the final type of surgery. The aim of this article is to discuss and review the evidence related to the endoscopic findings after bariatric surgery. Materials and Methods: A systematic review of the literature has been conducted, including all recent articles related to endoscopic findings after bariatric surgery. Our review of the literature has included 140 articles, of which, after final review, only eight were included. The polled articles included discussion of the endoscopy findings after roux-en-y gastric bypass and laparoscopic sleeve gastrectomy. Results: We found that the specific care of bariatric patients might include an endoscopic diagnosis when GERD symptoms are present. Conclusions: Recent evidence has shown that endoscopic follow-up after laparoscopic sleeve gastrectomy could be advisable, due to the pathological findings in endoscopic procedures in asymptomatic patients. Full article
(This article belongs to the Special Issue Current Trends in the Management of Gastroesophageal Reflux Disease (GERD), Obesity, and Bariatric Surgery)
7 pages, 571 KiB  
Review
Is It Safe to Combine a Fundoplication to Sleeve Gastrectomy? Review of Literature
by Sergio Carandina, Viola Zulian, Anamaria Nedelcu, Marc Danan, Ramon Vilallonga, David Nocca and Marius Nedelcu
Medicina 2021, 57(4), 392; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57040392 - 18 Apr 2021
Cited by 21 | Viewed by 2906
Abstract
Background and Objectives: The rising numbers of laparoscopic sleeve gastrectomy (LSG) procedures now being performed worldwide will likely be followed by an increasing number of patients experiencing gastro-esophageal reflux disease (GERD). The purpose of the current review was to analyze in terms of [...] Read more.
Background and Objectives: The rising numbers of laparoscopic sleeve gastrectomy (LSG) procedures now being performed worldwide will likely be followed by an increasing number of patients experiencing gastro-esophageal reflux disease (GERD). The purpose of the current review was to analyze in terms of safety different techniques of fundoplication used to treat GERD associated with LSG. Methods: An online search was performed in PubMed/MEDLINE in December 2020 to identify articles reporting LSG and fundoplication. The following term combination was used: (sleeve, fundoplication), (sleeve, Nissen), (sleeve, Rossetti), (sleeve, Toupet) and (sleeve, Dor). The extracted information included details of the methods (e.g., retrospective case series), demographic characteristics (e.g., age, gender), clinical characteristics, number of patients, rate of conversion, and postoperative outcomes. Results: A total of 154 studies were identified and after an assessment of title according to our exclusion criteria, 116 articles were removed. Of the 38 studies analyzed for full content review, a total of seven primary studies (487 patients) were identified with all inclusion criteria. Analyzing the different types of fundoplication used, we have identified: 236 cases of Nissen-Sleeve, 220 cases with modified Rossetti fundoplication, 31 cases of Dor fundoplication, and no case of Toupet fundoplication. The overall postoperative complication rate was 9.4%, with the most common reported complication being gastric perforation, 15 cases—3.1%. The second most common complication was bleeding identified in nine cases (1.8%) followed by gastric stenosis in six cases (1.2%). The mortality was nil. Conclusions: Different types of fundoplication associated with LSG appear to be a safe surgical technique with an acceptable early postoperative complication rate. Any type of fundoplication associated with LSG to decrease GERD should be evaluated cautiously while prospective clinical randomized trials are needed. Full article
(This article belongs to the Special Issue Current Trends in the Management of Gastroesophageal Reflux Disease (GERD), Obesity, and Bariatric Surgery)
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