Special Issue "Immunologic Checkpoint Molecules and Their Role in Reproduction and Cancer"

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 15 December 2021.

Special Issue Editor

Prof. Dr. Udo Jeschke
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

Immune checkpoint molecules, such as FasL/Fas, TIM-3/Gal-9, and PD-1/PD-L1, are regulators of immune responses of the fetus that prevent its rejection by the maternal immune system.

On the other hand, checkpoint inhibitors are among the most promising therapeutic approaches for the treatment of a variety of cancers, leading to strong immune responses against tumor cells by blocking PD1/PD-L1 or TIM-3/Gal-9. Immunostaining for PD-L1 has already become a valid predictive biomarker and is routinely analyzed in several types of cancer. Several reports have demonstrated that PD1/PD-L1 or TIM-3/Gal-9 inhibitors might be useful for cancer treatment approaches. However, there exist difficulties because of the tumor types studied; whether PD1/PD-L1 or TIM-3/Gal-9 expression is a good prognostic marker remains controversial.

In addition, interaction between the receptor Fas (CD95) and Fas Ligand (FasL, CD178) can efficiently induce apoptosis and is critical for the maintenance of immunological tolerance. In invasive carcinomas, the expression of Fas and FasL may be inversely related. During pregnancy, trophoblast and decidual FasL-expressing cells induce apoptosis in the Fas-bearing activated T-cells of the maternal–fetal interface, thus minimizing the risk of embryo rejection during implantation and early development.

Therefore, this Special Issue deals with a variety immunologic checkpoint molecules and their functions in reproductive immunology and cancer biology.

Prof. Dr. Udo Jeschke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • FasL/Fas
  • TIM-3/Gal-9
  • PD-1/PD-L1
  • reproductive immunology
  • cancer biology

Published Papers

This special issue is now open for submission.
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