Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
2.6
Journals
Medicina
Special Issues
Molecular and Clinical Diagnosis and Treatment of Endometriosis
share announcement

Molecular and Clinical Diagnosis and Treatment of Endometriosis

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Obstetrics and Gynecology".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 5355

Special Issue Editors

Dr. Quanah J. Hudson

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
Interests: embryology; developmental biology; genetics; epigenetics; endometriosis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ariane Germeyer

E-Mail Website
Guest Editor
Abteilung Gynäkologische Endokrinologie und Fertilitätsstörungen, Universität Heidelberg, Heidelberg, Germany
Interests: implantation; reproductive medicine; assisted reproductive technology; endometriosis
Dr. Iveta Yotova

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
Interests: endometriosis; lncRNAs; imprinting; epigenetics; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endometriosis is a common gynecological disease that adversely affects the health and quality of life of many women worldwide. The disease is associated with different forms of chronic or cyclic pain, as well as reduced fertility. The heterogeneity and many non-specific symptoms of the disease complicate diagnosis and can delay the onset of treatment of women with the disease. Until now, the diagnostic tools and the therapeutic options have been limited. Therefore, there is a need for new and improved diagnostic and treatment tools, developed either based on basic research into the mechanisms leading to the development of the disease, or from clinical research.

The purpose of this Special Issue is to present recent progress made towards improving the diagnostic and treatment options available for women affected by endometriosis. We welcome basic research and clinical studies addressing this issue, as well as comprehensive reviews on this topic. Please contact us if you have further questions about submitting a paper to this Special Issue.

Dr. Quanah J. Hudson
Prof. Dr. Ariane Germeyer
Dr. Iveta Yotova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • adenomyosis
  • deep infiltrating endometriosis
  • infertility
  • inflammation
  • pain
  • molecular diagnosis
  • biomarkers
  • surgical diagnosis
  • surgical treatment
  • laparoscopy
  • combined therapy
  • in vivo models
  • mouse models
  • ex vivo models
  • endometrial organoids
  • in vitro models
  • drug discovery
  • drug repurposing
  • personalized medicine

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1638 KiB  
Article
Evaluating the Phagocytic Index of Peripheral Leukocytes in Endometriosis by Plasma Experiments
by Luca Lukács, Anna Rebeka Kovács, László Pál, Sándor Szűcs and Rudolf Lampé
Medicina 2022, 58(7), 925; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58070925 - 12 Jul 2022
Cited by 4 | Viewed by 1855
Abstract
Background and Objectives: Endometriosis is a benign, chronic disease, that negatively influences the quality of life of affected women and is responsible for a remarkable amount of infertility. The pathophysiology of the disease is still not clarified, but the insufficient immune surveillance [...] Read more.
Background and Objectives: Endometriosis is a benign, chronic disease, that negatively influences the quality of life of affected women and is responsible for a remarkable amount of infertility. The pathophysiology of the disease is still not clarified, but the insufficient immune surveillance plays a significant role in it. The phagocyte function of innate immune cells may play a role in the elimination of ectopic endometrium. The purpose of this study is to examine the phagocyte function of neutrophil granulocytes and monocytes, incubated in heat-inactivated and not-inactivated plasma samples from healthy women and from women with endometriosis before and after the surgical treatment. Materials and Methods: Blood samples were collected from eight preoperative and eight postoperative patients with endometriosis before and after the surgical treatment, and from 16 healthy patients as controls. Neutrophil granulocytes, monocytes and blood plasma samples were isolated. Cells were incubated in different plasma samples, and the phagocytic index was determined with a fluorescence microscope. Results: The phagocytic index of granulocytes and monocytes isolated from patients with endometriosis was significantly decreased compared to healthy women after the cells were incubated in their own plasma. Preoperatively isolated cells from patients with endometriosis demonstrated an improved phagocyte function after incubating them in plasma samples from healthy controls. In contrast, the phagocytic activity of cells from healthy women significantly reduced after being incubated in the plasma of preoperative endometriosis patients. The heat-inactivation of plasma samples did not affect the results. Conclusions: Active endometriosis lesions may produce heat-stable systemic immunomodulatory factors, which reduced the phagocyte function of peripheral monocytes and neutrophil granulocytes. The phagocyte function of these cells can be normalized after the complete surgical removal of endometriosis, which then demonstrates similar values as in healthy women. Full article
(This article belongs to the Special Issue Molecular and Clinical Diagnosis and Treatment of Endometriosis)
►▼ Show Figures

Figure 1

14 pages, 3253 KiB  
Article
The Anti-Endometriotic Effect of Cyperi Rhizoma Extract, Inhibiting Cell Adhesion and the Expression of Pain-Related Factors through Akt and NF-kB Pathways
by Ji-Hye Ahn, Jun-Myeong Choi, Eun-Sol Kang, Jae-Hyeon Yoo, Yoon-Jin Cho, Dae Sik Jang and Jung-Hye Choi
Medicina 2022, 58(3), 335; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58030335 - 23 Feb 2022
Cited by 3 | Viewed by 2899
Abstract
Rhizomes of Cyperus rotundus have been widely used as a traditional medicine in Asia for the treatment of gynecological diseases. However, there is no scientific evidence demonstrating the effect of C. rotundus rhizomes on endometriosis, which is characterized by the adhesion of endometrial [...] Read more.
Rhizomes of Cyperus rotundus have been widely used as a traditional medicine in Asia for the treatment of gynecological diseases. However, there is no scientific evidence demonstrating the effect of C. rotundus rhizomes on endometriosis, which is characterized by the adhesion of endometrial tissues outside the uterus, resulting in chronic and severe pelvic pain. The aim of this study was to investigate the effects of Cyperi rhizoma extract (CRE) on cell adhesion and the expression of pain-related factors (neurotrophins) in endometriotic cells, and to elucidate the underlying molecular mechanisms. CRE inhibited the adhesion of human endometriotic 12Z cells to peritoneal mesothelial Met5A cells using by adhesion assays. The mRNA expression of adhesion molecules [P-cadherin and matrix metalloproteinase (MMP)-2] was downregulated by CRE treatment. In addition, CRE significantly inhibited the mRNA expression of neurotrophins (BDNF, NGF, NT-3 and NT-4/5) in 12Z cells. Moreover, Akt overexpression markedly neutralized the inhibition of cell adhesion by CRE and expression of neurotrophins in 12Z cells. Furthermore, it was found that CRE suppressed NF-kB activation through the Akt pathway. These data suggest that CRE exerts anti-endometriotic activities by the inhibition of cell adhesion and neurotrophin expression, through the negative regulation of the Akt and NF-kB pathways in endometriotic cells. Full article
(This article belongs to the Special Issue Molecular and Clinical Diagnosis and Treatment of Endometriosis)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop