Special Issue "Chronic Inflammatory Skin Diseases: Current Treatment and Future"

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 30 April 2022.

Special Issue Editor

Dr. Bo Young Chung
E-Mail Website
Guest Editor
Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Korea
Interests: psoriasis; acne; rosacea; atopic dermatitis; chronic urticaria; hidradenitis suppurativa

Special Issue Information

Dear Colleagues, 

Chronic inflammatory skin disease can be debilitating, tremendously impairing quality of life. The treatments for chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, contact dermatitis, rosacea, acne, chronic urticaria, and hidradenitis suppurativa, are challenging. Until recently, treatment was largely nonspecific and, in severe disease, sometimes ineffective with many side effects. Improved understanding of pathogenesis of chronic inflammatory skin diseases, effective targeted therapies are gradually available or in development.

This Special Issue aims to detail the direction of therapeutics in chronic inflammatory skin diseases, including psoriasis, atopic dermatitis, contact dermatitis, rosacea, acne, chronic urticaria, and hidradenitis suppurativa. This Special Issue will accept review articles, original research and case report material on relevant aspects and updated information on the treatment or pathophysiology.

This Special Issue will bring together these themes to illustrate the future landscape for chronic inflammatory skin disease care.

Dr. Bo Young Chung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • atopic dermatitis
  • contact dermatitis
  • rosacea
  • acne
  • chronic urticaria
  • hidradenitis suppurativa

Published Papers (2 papers)

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Research

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Article
The Role of Bradykinin Receptors in the Etiopathogenesis of Chronic Spontaneous Urticaria
Medicina 2021, 57(10), 1133; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57101133 - 19 Oct 2021
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Abstract
Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin. Recently, CSU has been associated with bradykinin release, which was previously discovered to be the main [...] Read more.
Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin. Recently, CSU has been associated with bradykinin release, which was previously discovered to be the main trigger of hereditary angioedema attacks. To study the role of bradykinin receptors 1 (BR1) and 2 (BR2) in the etiopathogenesis of CSU. Materials and Methods: A total of 60 individuals, 30 patients with CSU and 30 healthy subjects, were recruited to the study. CSU was diagnosed in accordance with the standardized protocol of dermatological assessment of skin symptoms. The level of bradykinin receptors was determined in populations of CD3+, CD4+, and CD8+ lymphocytes as well as in CD14++CD16, CD14++CD16+ and CD14+CD16+ monocytes. In addition, urticaria activity score summed over 7 days (UAS-7) was assessed and correlated with BR1 and BR2 expression. Results: A statistically significant higher concentration of BR1 expression in lymphocytes was found in patients with CSU, compared to the control group (p < 0.001). Moreover, a statistically significant positive correlation was observed between UAS-7 and BR1/BR2 expression in CD14++CD16 cells (p = 0.03, R = 0.4). Conclusions: Bradykinin receptors are elevated in selected populations of lymphocytes in symptomatic CSU patients compared to healthy controls, indicating their role in the etiopathogenesis of the disease. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
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Review

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Review
Contact Allergy Induced by Mango (Mangifera indica): A Relevant Topic?
Medicina 2021, 57(11), 1240; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57111240 - 13 Nov 2021
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Abstract
Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: We reviewed the original articles published on Pubmed, Embase and [...] Read more.
Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: We reviewed the original articles published on Pubmed, Embase and Cochrane Library before 15 September 2021, on the topic of contact allergy induced by mango and we synthesized the key data. Results: We found 12 case reports and four case series, with a total of 37 patients. Only seven of these cases were reported in patients from mango-cultivating countries, the other 30 were from countries where mango cultivation does not occur, and 26 were also from countries where poison ivy/oak are commonly found. We found that contact dermatitis may occur on the first exposure to mango due to previous sensitisation to urushiol-containing plants. The diagnosis was confirmed by patch testing in some of the cases. There was great heterogeneity between the reagents used. Conclusion: Mango fruit is frequently consumed, but mango induced contact dermatitis, the main hypersensitivity reaction induced by mango, is rare. Further data is necessary for a better understanding of sensitising substances and, consecutively, standardization of patch test reagents. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
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