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Medicina
Special Issues
Chronic Inflammatory Skin Diseases: Current Treatment and Future
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Chronic Inflammatory Skin Diseases: Current Treatment and Future

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 20467

Special Issue Editor

Prof. Dr. Bo Young Chung

E-Mail Website
Guest Editor
Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07441, Republic of Korea
Interests: psoriasis; acne; rosacea; atopic dermatitis; chronic urticaria; hidradenitis suppurativa
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Chronic inflammatory skin disease can be debilitating, tremendously impairing quality of life. The treatments for chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, contact dermatitis, rosacea, acne, chronic urticaria, and hidradenitis suppurativa, are challenging. Until recently, treatment was largely nonspecific and, in severe disease, sometimes ineffective with many side effects. Improved understanding of pathogenesis of chronic inflammatory skin diseases, effective targeted therapies are gradually available or in development.

This Special Issue aims to detail the direction of therapeutics in chronic inflammatory skin diseases, including psoriasis, atopic dermatitis, contact dermatitis, rosacea, acne, chronic urticaria, and hidradenitis suppurativa. This Special Issue will accept review articles, original research and case report material on relevant aspects and updated information on the treatment or pathophysiology.

This Special Issue will bring together these themes to illustrate the future landscape for chronic inflammatory skin disease care.

Dr. Bo Young Chung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriasis
  • atopic dermatitis
  • contact dermatitis
  • rosacea
  • acne
  • chronic urticaria
  • hidradenitis suppurativa

Published Papers (6 papers)

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Research

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12 pages, 1613 KiB  
Article
The Role of Bradykinin Receptors in the Etiopathogenesis of Chronic Spontaneous Urticaria
by Aleksander Obtulowicz, Pawel Dubiela, Wojciech Dyga, Kamila Migacz-Gruszka, Tomasz Mikolajczyk, Anna Wojas-Pelc and Krystyna Obtulowicz
Medicina 2021, 57(10), 1133; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57101133 - 19 Oct 2021
Cited by 1 | Viewed by 1701
Abstract
Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin. Recently, CSU has been associated with bradykinin release, which was previously discovered to be the main [...] Read more.
Background and Objectives: Chronic spontaneous urticaria (CSU) is a distressing skin condition, which manifests as red, swollen, itchy, and sometimes painful hives or wheals appearing on skin. Recently, CSU has been associated with bradykinin release, which was previously discovered to be the main trigger of hereditary angioedema attacks. To study the role of bradykinin receptors 1 (BR1) and 2 (BR2) in the etiopathogenesis of CSU. Materials and Methods: A total of 60 individuals, 30 patients with CSU and 30 healthy subjects, were recruited to the study. CSU was diagnosed in accordance with the standardized protocol of dermatological assessment of skin symptoms. The level of bradykinin receptors was determined in populations of CD3+, CD4+, and CD8+ lymphocytes as well as in CD14++CD16−, CD14++CD16+ and CD14+CD16+ monocytes. In addition, urticaria activity score summed over 7 days (UAS-7) was assessed and correlated with BR1 and BR2 expression. Results: A statistically significant higher concentration of BR1 expression in lymphocytes was found in patients with CSU, compared to the control group (p < 0.001). Moreover, a statistically significant positive correlation was observed between UAS-7 and BR1/BR2 expression in CD14++CD16− cells (p = 0.03, R = 0.4). Conclusions: Bradykinin receptors are elevated in selected populations of lymphocytes in symptomatic CSU patients compared to healthy controls, indicating their role in the etiopathogenesis of the disease. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
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Review

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17 pages, 351 KiB  
Review
Moisturizer in Patients with Inflammatory Skin Diseases
by Seok-Young Kang, Ji-Young Um, Bo-Young Chung, So-Yeon Lee, Jin-Seo Park, Jin-Cheol Kim, Chun-Wook Park and Hye-One Kim
Medicina 2022, 58(7), 888; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58070888 - 01 Jul 2022
Cited by 16 | Viewed by 7547
Abstract
As interest in skin increases, the cosmetic market is also growing. It is difficult to choose between the numerous types of basic cosmetics on the market. This article aims to provide advice and guidance on which products to recommend according to a patient’s [...] Read more.
As interest in skin increases, the cosmetic market is also growing. It is difficult to choose between the numerous types of basic cosmetics on the market. This article aims to provide advice and guidance on which products to recommend according to a patient’s skin condition. Appropriate application of a moisturizer attempts not only to improve the dryness, but also improve the skin’s natural barrier function to protect the skin from internal and external irritants to keep the skin healthy. Moisturizers consist of various ingredients, including occlusive agents, emollients, humectants, lipid mixture, emulsifiers, and preservatives. Pathophysiology of dry skin is also discussed to provide readers with the background they need to choose the right moisturizer for themselves. As moisturizers play an important role as adjuvant in the treatment of common skin diseases, such as atopic dermatitis, contact dermatitis, psoriasis, acne and rosacea, which type of moisturizer is appropriate for each disease was also dealt with. Basic cosmetics, especially moisturizers, should be recommended in consideration of the ingredients, effectiveness and safety of each product, and the skin condition of each patient. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
10 pages, 327 KiB  
Review
Ischemia-Modified Albumin—A Potential New Marker of Oxidative Stress in Dermatological Diseases
by Mircea Tampa, Cristina Iulia Mitran, Madalina Irina Mitran, Andreea Amuzescu, Clara Matei and Simona Roxana Georgescu
Medicina 2022, 58(5), 669; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58050669 - 17 May 2022
Cited by 12 | Viewed by 2518
Abstract
There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin [...] Read more.
There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. We have conducted a narrative review to evaluate the role of IMA in dermatological diseases. We have identified 24 original articles that evaluated IMA in skin disorders (psoriasis, acne vulgaris, hidradenitis suppurativa, urticaria, vitiligo and Behcet’s disease) and hair disorders (alopecia areata, androgenetic alopecia and telogen effluvium). The results of the studies analyzed reveal that IMA may be considered a new marker of oxidative stress in dermatological diseases and offer new insights into the pathogenesis of these disorders and the theoretical basis for the development of new, effective, targeted therapies. To the best of our knowledge, this is the first review that gathers up data on the role of IMA in dermatological diseases. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
11 pages, 306 KiB  
Review
Contact Allergy Induced by Mango (Mangifera indica): A Relevant Topic?
by Elena Camelia Berghea, Mihai Craiu, Selda Ali, Sabina Loredana Corcea and Roxana Silvia Bumbacea
Medicina 2021, 57(11), 1240; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57111240 - 13 Nov 2021
Cited by 7 | Viewed by 4110
Abstract
Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: We reviewed the original articles published on Pubmed, Embase and [...] Read more.
Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: We reviewed the original articles published on Pubmed, Embase and Cochrane Library before 15 September 2021, on the topic of contact allergy induced by mango and we synthesized the key data. Results: We found 12 case reports and four case series, with a total of 37 patients. Only seven of these cases were reported in patients from mango-cultivating countries, the other 30 were from countries where mango cultivation does not occur, and 26 were also from countries where poison ivy/oak are commonly found. We found that contact dermatitis may occur on the first exposure to mango due to previous sensitisation to urushiol-containing plants. The diagnosis was confirmed by patch testing in some of the cases. There was great heterogeneity between the reagents used. Conclusion: Mango fruit is frequently consumed, but mango induced contact dermatitis, the main hypersensitivity reaction induced by mango, is rare. Further data is necessary for a better understanding of sensitising substances and, consecutively, standardization of patch test reagents. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)

Other

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6 pages, 1920 KiB  
Case Report
Darier Disease with Psoriasis
by Seok-Young Kang, So-Yeon Lee, Jin-Seo Park, Jin-Cheol Kim, Bo-Young Chung, Chun-Wook Park and Hye-One Kim
Medicina 2022, 58(7), 902; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58070902 - 06 Jul 2022
Cited by 1 | Viewed by 1889
Abstract
Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. [...] Read more.
Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 48-year-old male patient presented skin lesions with pruritus on the trunk and both upper and lower extremities. He first noticed the lesion 15 years before. On physical examination, there were multiple erythematous papules with crust on the trunk and red-brown colored keratotic plaque on both extremities. The suspected histopathological diagnosis was psoriasis vulgaris. The patient’s skin lesions and pruritus were significantly improved after the psoriasis treatment. While continuing psoriasis treatment, the patient showed sudden worsening of the skin lesions on the scalp, abdomen, and fingernails (V-shaped nicks) with pruritus. Punch biopsy was performed on the abdominal lesion again and the final diagnosis was Darier disease. The patient was then treated using alitretinoin while maintaining the use of guselkumab for psoriasis. There are only a few cases that we found in which patients with Darier disease also had psoriasis. We report this rare case of Darier disease with psoriasis and propose that an additional biopsy might be necessary for accurate diagnosis and proper treatment. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
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7 pages, 4691 KiB  
Case Report
Apocrine Hidrocystoma with IgG4 Plasma Cell Infiltration Presenting as Recurrent Chalazion: A Case Report
by Shang-Yen Wu, Jin-Wei Huang, Yuan-Chieh Lee, Fang-Ling Chang, Ming-Hsun Li and Nancy Chen
Medicina 2022, 58(7), 840; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58070840 - 22 Jun 2022
Viewed by 1835
Abstract
Apocrine hidrocystomas are benign cystic tumors resulting from apocrine sweat glands’ proliferation. They typically present as solitary, slow-growing nodules at the head and neck, especially in the periorbital cutaneous region. We present a case of periorbital apocrine hidrocystoma in a 22-year-old woman that [...] Read more.
Apocrine hidrocystomas are benign cystic tumors resulting from apocrine sweat glands’ proliferation. They typically present as solitary, slow-growing nodules at the head and neck, especially in the periorbital cutaneous region. We present a case of periorbital apocrine hidrocystoma in a 22-year-old woman that was treated as chalazion previously. Besides the hallmark histopathological findings of apocrine hidrocystoma, IgG4 plasma cell infiltration of the cystic wall was also found. The ratio of IgG4-to-IgG-positive plasma cells was high, whereas serum IgG4 was within the standard limit. This is, to date, the only probable IgG4-related ophthalmic disease associated with apocrine hidrocystoma. Full article
(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
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