Diagnosis and Treatment of Non-muscle Invasive Bladder Cancer

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (15 October 2021) | Viewed by 4800

Special Issue Editor


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Guest Editor
1. Department of Urology and Pediatric Urology, Malteser Hospital St. Josfeshospital, Krefeld-Uerdingen, Germany
2. University of Duisburg – Essen, Department of Urology, Essen, Germany
Interests: bladder cancer: prevention; diagnostics; early detection; surgical techniques; urine-based tumor markers; risk assessment; intravesical treatment; immunotherapy; geriatric oncology

Special Issue Information

Dear Colleagues,

Bladder cancer is the second most frequent urothelial cancer that occurs most often in elderly patients. At first detection, about 75% of cases are non-muscle-invasive bladder cancers (NMIBC), with a generally high recurrence rate and a high risk of progression in some. This makes NMIBC not only a bothersome disease that requires long-term treatment and follow up for the patients but also a disease with a high socio-economic burden.

Since risk factors such as smoking and aromatic amines are well established, exposure reduction is mandatory. Further options are early detection and an optimal primary treatment with a combined treatment of transurethral resection and intravesical instillation including all kind of immunoncological approaches. In the future, histopathological subtype differentiation and testing for genetic tumour alterations will become more and more important in clinical routine.

Given the high importance of bladder cancer in the field of uro-oncology and research, the journal Medicina is launching this Special Issue.

We encourage you and your co-workers to submit your articles reporting on this topic. Reviews or original articles dealing with epidemiological aspects, the prevention and the early detection of bladder cancer are welcome. Further topics for this Special Issue should include optimized primary treatments, risk assessments and the optimal follow-up management of NMIBC. In addition, we warmly invite you to submit articles reporting on histopathological and molecular subtype differentiations of the bladder as well as the increasing relevance of genetic alterations in this disease.

Dr. Marcus Horstmann
Guest Editor

Manuscript Submission Information

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Keywords

  • Bladder cancer
  • Non-muscle-invasive bladder cancer
  • Epidemiology
  • Risk factors
  • Transurehtral resection
  • Early detection
  • Intravesial treatment
  • Subtype differentiation
  • Genetic alterations

Published Papers (1 paper)

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Research

19 pages, 5739 KiB  
Article
Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling: Computational Drug Repositioning Approach
by Arif Jamal Siddiqui, Mohammad Faheem Khan, Walid Sabri Hamadou, Manish Goyal, Sadaf Jahan, Arshad Jamal, Syed Amir Ashraf, Pankaj Sharma, Manojkumar Sachidanandan, Riadh Badraoui, Kundan Kumar Chaubey, Mejdi Snoussi and Mohd Adnan
Medicina 2021, 57(10), 1058; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57101058 - 03 Oct 2021
Cited by 10 | Viewed by 4279
Abstract
Urogenital schistosomiasis is caused by Schistosoma haematobium (S. haematobium) infection, which has been linked to the development of bladder cancer. In this study, three repurposing drugs, ivermectin, arteether and praziquantel, were screened to find the potent drug-repurposing candidate against the Schistosoma [...] Read more.
Urogenital schistosomiasis is caused by Schistosoma haematobium (S. haematobium) infection, which has been linked to the development of bladder cancer. In this study, three repurposing drugs, ivermectin, arteether and praziquantel, were screened to find the potent drug-repurposing candidate against the Schistosoma-associated bladder cancer (SABC) in humans by using computational methods. The biology of most glutathione S-transferases (GSTs) proteins and vascular endothelial growth factor (VEGF) is complex and multifaceted, according to recent evidence, and these proteins actively participate in many tumorigenic processes such as cell proliferation, cell survival and drug resistance. The VEGF and GSTs are now widely acknowledged as an important target for antitumor therapy. Thus, in this present study, ivermectin displayed promising inhibition of bladder cancer cells via targeting VEGF and GSTs signaling. Moreover, molecular docking and molecular dynamics (MD) simulation analysis revealed that ivermectin efficiently targeted the binding pockets of VEGF receptor proteins and possessed stable dynamics behavior at binding sites. Therefore, we proposed here that these compounds must be tested experimentally against VEGF and GST signaling in order to control SABC. Our study lies within the idea of discovering repurposing drugs as inhibitors against the different types of human cancers by targeting essential pathways in order to accelerate the drug development cycle. Full article
(This article belongs to the Special Issue Diagnosis and Treatment of Non-muscle Invasive Bladder Cancer)
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