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Medicina
Special Issues
Emerging Therapies for Non-small Cell Lung Cancer
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Emerging Therapies for Non-small Cell Lung Cancer

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pulmonary".

Deadline for manuscript submissions: closed (1 June 2021) | Viewed by 2334

Special Issue Editor

Dr. Hisao Imai

E-Mail Website
Guest Editor
Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, 1397-1 Yamane, Hidaka-City 350-1298, Saitama, Japan
Interests: thoracic oncology; lung cancer; immunotherapy; chemotherapy; medical oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-small cell lung cancer (NSCLC) is the second most common cancer globally and a major cause of cancer-related death. As the elderly population continues to increase worldwide, the number of elderly patients with advanced NSCLC is rising on a global scale.

Although the treatment of non-small cell lung cancer has become complicated due to the emergence of immune checkpoint inhibitors, the prognosis of patients has been prolonged, and treatment is improving day by day. We have decided to issue a Special Issue this time on the progress of treatment of non-small cell lung cancer.

This Special Issue will highlight and summarize the current knowledge concerning the Emerging Therapies for Non-Small Cell Lung Cancer, covering both basic and (pre)clinical aspects. Potential studies may include assessment of the Emerging Therapies for Non-Small Cell Lung Cancer. For this Special Issue, we invite investigators to contribute with original articles as well as review articles that will describe and help in understanding the current and potential challenges surrounding “Emerging Therapies for Non-Small Cell Lung Cancer”.

Dr. Hisao Imai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Thoracic oncology
  • Non-small cell lung cancer
  • Small cell lung cancer
  • Chemotherapy
  • Advanced lung cancer

Published Papers (1 paper)

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Research

12 pages, 1030 KiB  
Article
Post-Progression Survival Is Strongly Associated with Overall Survival in Patients Exhibiting Postoperative Relapse of Non-Small-Cell Lung Cancer Harboring Sensitizing EGFR Mutations
by Hisao Imai, Ryoichi Onozato, Maiko Ginnan, Daijiro Kobayashi, Kyoichi Kaira and Koichi Minato
Medicina 2021, 57(5), 508; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57050508 - 19 May 2021
Cited by 2 | Viewed by 1896
Abstract
Background and Objective: Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitizing epidermal growth factor receptor (EGFR) mutations show a good response to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). The subsequent treatments influence the evaluability of the efficacy of front-line therapy on [...] Read more.
Background and Objective: Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitizing epidermal growth factor receptor (EGFR) mutations show a good response to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). The subsequent treatments influence the evaluability of the efficacy of front-line therapy on overall survival (OS). Consequently, we evaluated the associations of relapse-free survival (RFS) and post-progression survival (PPS) with OS in patients who exhibited postoperative relapse of EGFR-mutated NSCLC. Materials and Methods: We analyzed the data of 35 patients with EGFR-mutated NSCLC who underwent complete resection between January 2007 and June 2019. The correlations of RFS and PPS with OS were evaluated at the individual patient level. Results: Linear regression and Spearman’s rank correlation analyses demonstrated that the PPS highly correlated with OS (r = 0.91, p < 0.05, R2 = 0.85), whereas the RFS weakly associated with OS (r = 0.36, p < 0.05, R2 = 0.25). Age and performance status at relapse were significantly associated with PPS. Conclusion: Overall, PPS was more strongly and significantly associated with OS than RFS. These results suggest that the OS of our cohort may be affected by treatments, besides postoperative relapse. However, larger-scale prospective studies are needed to confirm these results. Full article
(This article belongs to the Special Issue Emerging Therapies for Non-small Cell Lung Cancer)
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