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Parkinson’s Disease and Beyond: Challenges and Perspectives
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Parkinson’s Disease and Beyond: Challenges and Perspectives

A special issue of Medicines (ISSN 2305-6320). This special issue belongs to the section "Neurology and Neurologic Diseases".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 7744

Special Issue Editor

Dr. Sara Palermo

E-Mail Website
Guest Editor
1 Department of Psychology, University of Turin, Turin, Italy
2 Neuroradiology Unit, Department of Diagnostic and Technology, Fondazione IRCCS Isttuto Neurologico Carlo Besta, Milan, Italy
Interests: successful ageing; frailty; neurocognitive disorders; neuropsychology; metacogni-tive–executive functions; placebo; pain; neuroimaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

PD patients fight against a range of physical motor and nonmotor symptoms, which affect their daily living. Because of the complexity of the disease, each patient has different combination symptoms, and consequently, difficulties in daily life. This complexity means that therapy for advanced stages of disease will vary from patient to patient—and might be an innovation in care, new nonpharmacological interventions, new ICT–IoT solutions or a new cocktail of drugs. In the case of complementary therapies (e.g., psychomotor rehabilitation, music therapy, dance therapy, museotherapy, acupuncture, nutriceutics), the latter must be modulated according to the individual.

Not only must the treatment be highly personalized, but all the potential obstacles to implementing that treatment plan also need to be assessed. An increasing attention in the characterization of the neuropsychological and neuropsychiatric profile in Parkinson's disease is necessary. Among all parameters, behavioral alterations (e.g., ICD), metacognitive–executive dysfunctions, and dyskinesia-reduced-self-awareness must be diagnosed and monitored. Importantly, a correct management might also take into account patient’ vulnerability. Parkinson’s disease and frailty may overlap, and screening for frailty in PD patients may be warranted.

The purpose of this Special Issue is to gather visionary ideas and perspectives on the main treatment approaches (pharmacological, rehabilitative, neurosurgical), evaluating benefits and potential iatrogenic effects on the quality of life, emotion, cognition, and autonomy of the Parkinsonian patient. Aspects concerning the caregiver’s burden are also taken into consideration.

Dr. Sara Palermo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s disease
  • therapies
  • rehabilitation
  • neuropsychology
  • behavior
  • metacognition
  • executive functions
  • reduced-self-awareness
  • frailty
  • quality of life

Published Papers (2 papers)

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Research

19 pages, 939 KiB  
Article
A Goal Intervention Improves Language Fluency: Evidence from Parkinson’s Disease and Healthy Aging
by Gail A. Robinson, Lara Campbell and Amelia Ceslis
Medicines 2021, 8(3), 15; https://0-doi-org.brum.beds.ac.uk/10.3390/medicines8030015 - 22 Mar 2021
Cited by 1 | Viewed by 3763
Abstract
Background: Parkinson’s disease [PD] is associated with reduced motor and cognitive initiation, and decreased goal-directed behavior including language generation. The current study investigated a novel goal intervention for language generation impairments in PD patients. Methods: Twenty-one PD patients and 22 healthy controls, [...] Read more.
Background: Parkinson’s disease [PD] is associated with reduced motor and cognitive initiation, and decreased goal-directed behavior including language generation. The current study investigated a novel goal intervention for language generation impairments in PD patients. Methods: Twenty-one PD patients and 22 healthy controls, matched for gender, age, and education, completed a cognitive baseline and language generation tasks (complex scene descriptions and phonemic/semantic word fluency) with standard and adapted instructions, which implements a target ‘goal’. In addition, participants completed self-report questionnaires for apathy and mood. Results: PD patients performed more poorly on two of three language generation tasks. The goal intervention was effective in increasing both the PD patient and healthy control groups’ language generation. However, there was no differential benefit of increased goal specificity and difficulty for PD patients. As a group, PD patients reported higher levels of apathy and depression than healthy controls. Specifically, PD patients with executive apathy were more likely to have language generation impairments than PD patients without executive apathy and controls. Apathy subscales and goal benefit were unrelated. Conclusions: The goal intervention was effective for PD patients and older adults, suggesting that enhanced goal specificity and difficulty may benefit individuals with PD or those aging naturally. Full article
(This article belongs to the Special Issue Parkinson’s Disease and Beyond: Challenges and Perspectives)
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9 pages, 940 KiB  
Article
Relationship between Motor Estimation Error and Physical Function in Patients with Parkinson’s Disease
by Katsuya Sakai, Tsubasa Kawasaki, Yumi Ikeda, Keita Tominaga and Kohei Kurihara
Medicines 2020, 7(8), 43; https://0-doi-org.brum.beds.ac.uk/10.3390/medicines7080043 - 28 Jul 2020
Cited by 4 | Viewed by 3456
Abstract
Background: Motor estimation error is an index of how accurately one’s body movement is recognized. This study determines whether motor estimation error distance is a Parkinson’s disease (PD)- or age-related disability using a two-step task. Methods: The participants were 19 PD [...] Read more.
Background: Motor estimation error is an index of how accurately one’s body movement is recognized. This study determines whether motor estimation error distance is a Parkinson’s disease (PD)- or age-related disability using a two-step task. Methods: The participants were 19 PD patients and 58 elderly people with disabilities. A two-step prediction test and an actual two-step test were performed. The motor estimation error distance (prediction of two-step distance minus actual two-step distance) and error rate between the two groups were compared. We conducted a correlation analysis between the motor estimation error and clinical factor (e.g., Hoehn and Yahr stage (H & Y), Unified Parkinson’s Disease Rating Scale (UPDRS)) related to PD. Results: The motor estimation error distance was not significantly different between the PD patient group and the elderly group with disabilities. However, significant correlations between motor estimation error and H & Y, and between motor estimation error and UPDRS part II, were observed. The error rate was significantly correlated with the Fall Efficacy Scale. Conclusions: The motor estimation error distance is influenced by both aging and PD. Full article
(This article belongs to the Special Issue Parkinson’s Disease and Beyond: Challenges and Perspectives)
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