Instructions for Authors


    Submission Checklist


    1. read the Aims & Scope to gain an overview and assess if your manuscript is suitable for this journal;
    2. use the Microsoft Word template (Protocol), Microsoft Word template (Data Descriptor) or Microsoft Word template (types of papers other than Protocols or Data Descriptor) or LaTeX template to prepare your manuscript;
    3. make sure that issues about publication ethics, research ethics, copyright, authorship, figure formats, data and references format have been appropriately considered;
    4. Ensure that all authors have approved the content of the submitted manuscript.
    5. Authors are encouraged to add a biography (optional) to the submission and publish it.

    Manuscript Submission Overview

    Types of Publications

    Metabolites has no restrictions on the length of manuscripts, provided that the text is concise and comprehensive. Full experimental details must be provided so that the results can be reproduced. Metabolites requires that authors publish all experimental controls and make full datasets available where possible (please read the guidelines about Supplementary Materials and references to unpublished data carefully).

    Manuscripts submitted to Metabolites should neither been published before nor be under consideration for publication in another journal. The main article types are as follows:

    • Articles: research manuscripts that report new evidence or new conclusions. The journal considers all original research manuscripts provided that the work reports scientifically sound experiments and provides a substantial amount of new information. Authors should not unnecessarily divide their work into several related manuscripts, although short Communications of preliminary, but significant, results will be considered. Replications of previous studies are permitted if clearly indicated as such.
    • Data descriptor: focusing on describing how the data in a dataset is collected, treated and possibly analyzed, and how to read and use the dataset. Dataset will be held at a third party repository. Please use the Data Descriptor template to prepare your manuscript.
    • Reviews: review manuscripts provide concise and precise updates on the latest progress made in a given area of research. Systematic reviews should follow the PRISMA guidelines.
    • Protocols: articles covering step-by-step procedural instructions to a new method/technique, or to substantial modifications of already existing methods/techniques.

    Expanded and high quality Conference Papers are also considered in Metabolites if they fulfill the following requirements: (1) the paper should be expanded to the size of a research article; (2) the conference paper should be cited and noted on the first page of the paper; (3) if the authors do not hold the copyright to the published conference paper, authors should seek the appropriate permission from the copyright holder; (4) authors are asked to disclose that it is conference paper in their cover letter and include a statement on what has been changed compared to the original conference paper. As a journal policy we do not publish pilot studies or studies with inadequate statistical power.


    Videoarticles are detailed, step-by-step experimental demonstrations that illustrate new protocols by presenting the material, equipment and actions required to conduct the experiment described in a Protocol paper. They increase the reproducibility and visibility of newly developed protocols and can also be used as teaching aids. We welcome the submission of Videoarticles demonstrating new protocols in any scientific discipline covered by Metabolites.

    Videoarticles will be published alongside textual protocols under a Creative Commons CC BY license, meaning that they are freely accessible and downloadable, and can be reused if correctly cited. We encourage sharing of Videoarticles, including via social media. In order for your research to reach the broadest audience possible, only Videoarticles in English will be considered for publication. All Videoarticles will be checked for editorial suitability and quality, as well as for correspondence to the Protocol paper.

    Please note that your video should not contain any music, sound effects or background talking, nor overt product promotion. Before preparing your Videoarticle, please read the Guidelines and Tips for Videoarticle production; the slides to introduce the different sections in Videoarticles can be downloaded here.

    Submission Process

    Manuscripts for Metabolites should be submitted online at The submitting author, who is generally the corresponding author, is responsible for the manuscript during the submission and peer-review process. The submitting author must ensure that all eligible co-authors have been included in the author list (read the criteria to qualify for authorship) and that they all have read and approved the submitted version of the manuscript. To submit your manuscript, register and log in to the submission website. Once you have registered, click here to go to the submission form for Metabolites. All co-authors can see the manuscript details in the submission system, if they register and log in using the e-mail address provided during manuscript submission.

    Accepted File Formats

    Authors must use the Microsoft Word template or LaTeX template to prepare their manuscript. Using the template file will substantially shorten the time to complete copy-editing and publication of accepted manuscripts. Accepted file formats are:

    • Microsoft Word: Manuscripts prepared in Microsoft Word must be converted into a single file before submission. When preparing manuscripts in Microsoft Word, the Metabolites Microsoft Word template file must be used. Please insert your graphics (schemes, figures, etc.) in the main text after the paragraph of its first citation.
    • LaTeX: Manuscripts prepared in LaTeX must be collated into one ZIP folder (including all source files and images, so that the Editorial Office can recompile the submitted PDF). When preparing manuscripts in LaTeX, please use the Metabolites LaTeX template files. You can now also use the online application writeLaTeX to submit articles directly to Metabolites. The MDPI LaTeX template file should be selected from the writeLaTeX template gallery.
    • Supplementary files: May be any format, but it is recommended that you use common, non-proprietary formats where possible (see below for further details).

    Cover Letter

    A cover letter must be included with each manuscript submission. It should be concise and explain why the content of your paper is significant, placing your findings in the context of existing work and why it fits the scope of the journal. Please confirm that neither the manuscript nor any parts of its content are currently under consideration or published in another journal. Any prior submissions of the manuscript to MDPI journals must be acknowledged. The names of proposed and excluded reviewers should be provided in the submission system, not in the cover letter.

    Author Biography

    Authors are encouraged to add a biography (maximum 150 words) to the submission and publish it. This should be a single paragraph and should contain the following points:

    1. Authors’ full names followed by current positions;
    2. Education background including institution information and year of graduation (type and level of degree recieved);
    3. Work experience;
    4. Current and previous research interests;
    5. Memberships of professional societies and awards received.

    Note for Authors Funded by the National Institutes of Health (NIH)

    This journal automatically deposits papers to PubMed Central after publication of an issue. Authors do not need to separately submit their papers through the NIH Manuscript Submission System (NIHMS,

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    Manuscript Preparation

      General Considerations

      • A Data Descriptor manuscript should comprise:
        • Front matter: Title, Author list, Affiliations, Abstract, Keywords
        • Dataset information: title, DOI (or unique identifier), creator, publisher and location (e.g. URL) of the dataset
        • Data Descriptor sections: Summary, Data Description, Methods, User notes (optional), Supplementary Materials
        • Back matter: Acknowledgments, Author Contributions, Conflicts of Interest, References.
      • Research manuscripts should comprise:
      • Review manuscripts should comprise the front matter, literature review sections and the back matter. The template file can also be used to prepare the front and back matter of your review manuscript. It is not necessary to follow the remaining structure. Structured reviews and meta-analyses should use the same structure as research articles and ensure they conform to the PRISMA guidelines.
      • Graphical Abstract:

        A graphical abstract (GA) is an image that appears alongside the text abstract in the Table of Contents. In addition to summarizing the content, it should represent the topic of the article in an attention-grabbing way. Moreover, it should not be exactly the same as the Figure in the paper or just a simple superposition of several subfigures. Note that the GA must be original and unpublished artwork. Any postage stamps, currency from any country, or trademarked items should not be included in it.

        The GA should be a high-quality illustration or diagram in any of the following formats: PNG, JPEG, TIFF, or SVG. Written text in a GA should be clear and easy to read, using one of the following fonts: Times, Arial, Courier, Helvetica, Ubuntu or Calibri.

        The minimum required size for the GA is 560 × 1100 pixels (height × width). The size should be of high quality in order to reproduce well.

      • Abbreviations: should be defined in parentheses the first time they appear in the abstract, main text, and in figure or table captions.
      • SI Units (International System of Units) should be used. Imperial, US customary and other units should be converted to SI units whenever possible
      • Equations: If you are using Word, please use either the Microsoft Equation Editor or the MathType add-on. Equations should be editable by the editorial office and not appear in a picture format.
      • Research Data and supplementary materials: Note that publication of your manuscript implies that you must make all materials, data, and protocols associated with the publication available to readers. Please disclose at the submission stage any restrictions on the availability of materials or information. Read the information about Supplementary Materials and Data Deposit for additional guidelines.
      • Preregistration: Where authors have preregistered studies or analysis plans, links to the preregistration must be provided in the manuscript.
      • Guidelines and standards: MDPI follows standards and guidelines for certain types of research. See for further information.
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