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Metabolites
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Techniques to Understand the Regulation of Central Carbon Metabolism and...
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Techniques to Understand the Regulation of Central Carbon Metabolism and Fatty Acids in the Liver

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 6477

Special Issue Editor

Dr. Rohit Mahar

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32603, USA
Interests: NMR; Mass Spectrometry; Metabolomics; Lipidomics; Flux analysis; Metabolic Imaging

Special Issue Information

Dear Colleagues,

Over the past few decades, many techniques have been developed to help us understand the energy metabolism and overall homeostasis of the liver. Many technological advancements have taken place, including sample preparation strategies, analytical techniques, lipidomics, and metabolomics. This Special Issue of Metabolites, "Techniques to Understand the Regulation of Central Carbon Metabolism and Fatty Acids in the Liver," will be dedicated to analytical techniques dealing with central carbon and fatty acid metabolism, including NMR, Mass Spectrometry, data analysis, and handling procedures. The objects of study could be humans, animals, and cell cultures, specifically with regards to liver metabolism. The topics that will be covered by this Special Issue include, but are not limited to: identification of metabolites/biomarkers in liver diseases, application of metabolomic methods used to analyze liver samples, metabolic flux analysis, identification and sensitive quantification of diverse metabolites and lipids, and empirical and computational methods of annotating metabolites and lipids in the liver. Manuscripts dealing with other pertinent and challenging issues in liver metabolism are also highly desired.

Dr. Rohit Mahar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • NMR
  • LC-MS
  • GC-MS
  • Metabolomics
  • Isotope tracer
  • Central Carbon Metabolism
  • Lipidomics
  • Metabolic modeling

Published Papers (2 papers)

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Research

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21 pages, 759 KiB  
Article
FADS Polymorphisms Affect the Clinical and Biochemical Phenotypes of Metabolic Syndrome
by Aleš Žák, Marie Jáchymová, Michal Burda, Barbora Staňková, Miroslav Zeman, Adolf Slabý, Marek Vecka and Ondřej Šeda
Metabolites 2022, 12(6), 568; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12060568 - 20 Jun 2022
Cited by 1 | Viewed by 1821
Abstract
Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS) [...] Read more.
Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS) independent of clinical and biochemical parameters within the whole study group (controls together with metabolic syndrome (MetS) patients). FA desaturase (FADS) genes are the key regulators of LC-PUFA metabolism. The aim of this study was to analyze associations between FADS polymorphisms and clusters of MetS. The study group consisted of 188 controls and 166 patients with MetS. The first cluster contained 71 controls (CON1) and 109 MetS patients (MetS1). The second cluster consisted of 117 controls (CON2) and 57 MetS patients (MetS2). In comparison with MetS2, cluster MetS1 displayed a more adverse risk profile. Cluster CON1 had, in comparison with CON2, higher body weight and increased triacylglycerol levels (p < 0.05). We found that the FADS rs174537 (p < 0.001), rs174570 (p < 0.01), and rs174602 (p < 0.05) polymorphisms along with two inferred haplotypes had statistically significant genotype associations with the splitting of MetS into MetS1 and MetS2. Conversely, we observed no significant differences in the distribution of FADS polymorphisms between MetS and CON subjects, or between CON1 and CON2. These associations between FADS polymorphisms and two clusters of MetS (differing in waist circumference, HOMA-IR, lipolysis, and oxidative stress) implicate the important influence of genetic factors on the phenotypic manifestation of MetS. Full article
(This article belongs to the Special Issue Techniques to Understand the Regulation of Central Carbon Metabolism and Fatty Acids in the Liver)
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Review

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30 pages, 2962 KiB  
Review
Nonalcoholic Fatty Liver Disease and Endocrine Axes—A Scoping Review
by Madalena Von-Hafe, Marta Borges-Canha, Catarina Vale, Ana Rita Leite, João Sérgio Neves, Davide Carvalho and Adelino Leite-Moreira
Metabolites 2022, 12(4), 298; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12040298 - 29 Mar 2022
Cited by 18 | Viewed by 4065
Abstract
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summarize the [...] Read more.
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease. NAFLD often occurs associated with endocrinopathies. Evidence suggests that endocrine dysfunction may play an important role in NAFLD development, progression, and severity. Our work aimed to explore and summarize the crosstalk between the liver and different endocrine organs, their hormones, and dysfunctions. For instance, our results show that hyperprolactinemia, hypercortisolemia, and polycystic ovary syndrome seem to worsen NAFLD’s pathway. Hypothyroidism and low growth hormone levels also may contribute to NAFLD’s progression, and a bidirectional association between hypercortisolism and hypogonadism and the NAFLD pathway looks likely, given the current evidence. Therefore, we concluded that it appears likely that there is a link between several endocrine disorders and NAFLD other than the typically known type 2 diabetes mellitus and metabolic syndrome (MS). Nevertheless, there is controversial and insufficient evidence in this area of knowledge. Full article
(This article belongs to the Special Issue Techniques to Understand the Regulation of Central Carbon Metabolism and Fatty Acids in the Liver)
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