Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.3
4.1
Journals
Metabolites
Special Issues
Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways...
share announcement

Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways and Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 7039

Special Issue Editors

Prof. Dr. Fatemeh Vida Zohoori

E-Mail Website
Guest Editor
School of Health & Life Sciences, Centre for Public Health Research, Teesside University, Middlesbrough Tees Valley TS1 3BX, UK
Interests: public health and nutrition；oral health and fluorides；dietary assessment methods；biomarkers of exposure
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marilia Buzalaf

E-Mail Website
Guest Editor
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, Brazil
Interests: fluoride intake; fluoride metabolism; fluoride toxicity; biomarkers of exposure to fluoride; proteomics

Special Issue Information

Dear Colleagues,

Fluoride is widely used to control dental caries, but excessive intake can negatively impact both hard and soft tissues, with dental fluorosis being the most well-established side effect.

The burden of fluoride on the body is tightly regulated and has a direct impact at both cellular and systemic levels. Fluoride metabolism can be affected by any systemic, metabolic and genetic alteration. Imbalances may lead to pathological conditions such as acute and chronic toxicities and dental and skeletal fluorosis.

On the other hand, several biochemical pathways, such as redox balance, signal transduction and apoptosis, could be obstructed by exposure to higher doses of fluoride. Some of the metabolic effects of fluoride are related to its ability to inhibit enolase, leading to an alteration in energy metabolism. Fluoride also interferes with the course of metabolic diseases, such as diabetes.

The advent of OMICS technologies in the last few decades has provided a better understanding of the effects of fluoride on metabolic pathways. Although considerable progress has been achieved, there is still much to be explored.

This Special Issue is devoted to bringing together information on fluoride metabolism and relevant regulating factors as well as its effects on metabolic pathways and metabolic diseases. We therefore invite submissions in the form of reviews and original manuscripts focusing on environmental, biochemical, physiological, pathological and molecular factors affecting fluoride metabolism, as well as the effects of fluoride on metabolic pathways and diseases.

The Special Issue is open for submission now. A proper extension may be granted. Please kindly let us know in advance. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website. 

Prof. Dr. Fatemeh Vida Zohoori
Prof. Dr. Marilia Buzalaf
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fluoride
  • Metabolism
  • Metabolic pathways
  • Metabolic diseases
  • Diabetes

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

22 pages, 3243 KiB  
Article
Effect of Physical Exercise and Genetic Background on Glucose Homeostasis and Liver/Muscle Proteomes in Mice
by Mileni S. Fernandes, Isabela T. Sabino-Arias, Aline Dionizio, Mayara F. Fabricio, Juliana S. Trevizol, Tatiana Martini, Liane B. Azevedo, Ruth A. Valentine, Anne Maguire, Fatemeh V. Zohoori, Sandra L. Amaral and Marília A. R. Buzalaf
Metabolites 2022, 12(2), 117; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12020117 - 25 Jan 2022
Cited by 1 | Viewed by 2000
Abstract
We compared the parameters related to glucose homeostasis, and liver and muscle proteomes in fluorosis-susceptible (A/J; S) and fluorosis-resistant (129P3/J; R) mice in response to fluoride (F) exposure and exercise. Ninety male mice (45 R-mice and 45 S-mice) were randomized into three groups: [...] Read more.
We compared the parameters related to glucose homeostasis, and liver and muscle proteomes in fluorosis-susceptible (A/J; S) and fluorosis-resistant (129P3/J; R) mice in response to fluoride (F) exposure and exercise. Ninety male mice (45 R-mice and 45 S-mice) were randomized into three groups: (SI; RI) No-F, No-Exercise, (SII; RII) 50 ppm F, No-Exercise, (SIII; RIII) 50 ppm F, Exercise. Overall, mean F concentrations in the plasma and femur were significantly higher in R-mice compared with S-mice. In R-mice, exercise resulted in an increase in F accumulation in the femur. In S-mice, the mean plasma glucose level was significantly higher in Group II compared with Groups I and III. There was an increase in liver proteins involved in energy flux and antioxidant enzymes in non-exercise groups (I, II) of S-mice in comparison with the corresponding groups of R-mice. The results also showed a decrease in muscle protein expression in Group I S-mice compared with their R-mice counterparts. In conclusion, the findings suggest an increased state of oxidative stress in fluorosis-susceptible mice that might be exacerbated by the treatment with F. In addition, fluorosis-susceptible mice have plasma glucose levels higher than fluorosis-resistant mice on exposure to F, and this is not affected by exercise. Full article
(This article belongs to the Special Issue Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways and Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

12 pages, 899 KiB  
Review
Fluoride Metabolism in Pregnant Women: A Narrative Review of the Literature
by Gina A. Castiblanco-Rubio and E. Angeles Martinez-Mier
Metabolites 2022, 12(4), 324; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12040324 - 02 Apr 2022
Cited by 4 | Viewed by 3518
Abstract
Epidemiological studies use biomarkers of fluoride exposure in pregnant women as surrogate measures of fetal fluoride exposure; however, there is little understanding of how pregnancy affects fluoride metabolism and its biomarkers. This narrative review summarizes the changes of pregnancy that have the potential [...] Read more.
Epidemiological studies use biomarkers of fluoride exposure in pregnant women as surrogate measures of fetal fluoride exposure; however, there is little understanding of how pregnancy affects fluoride metabolism and its biomarkers. This narrative review summarizes the changes of pregnancy that have the potential to impact fluoride’s absorption, distribution and excretion, and highlights the limited body of evidence on the topic. The physiologic systems that experience pregnancy-associated changes relevant to fluoride’s metabolism are the cardiovascular, renal, metabolic and gastrointestinal, as well bone and calcium metabolism and the body’s acid-base balance. The available evidence indicates that fluoride is found in the maternal plasma and urine, placenta, amniotic fluid and fetus. Although plasma and urinary fluoride vary across gestation, there is insufficient quality evidence to determine the direction or extent of such variation. Furthermore, there is no doubt that fluoride from maternal blood crosses the placenta and is absorbed and excreted by the fetus; however, the biological mechanisms behind this placental passage are unknown. Research on maternal and prenatal biomarkers of fluoride exposure would benefit from studies on how pregnancy-associated changes affect the metabolism of fluoride across gestation, the mechanisms for the intestinal absorption of fluoride in pregnant women, and the placental passage of fluoride. Full article
(This article belongs to the Special Issue Fluoride Metabolism and the Effects of Fluoride on Metabolic Pathways and Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop