Metabolism Applications in Histone Deacetylase Inhibitors
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Pharmacology and Drug Metabolism".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4694
Special Issue Editors
Interests: drug discovery; epigenetics; medicinal chemistry; chemical biology; radiopharmaceuticals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recently, epigenetics research has shed light on the effects of histone acetylation on metabolism, establishing multiple links between histone deacetylases (HDACs), including sirtuins (SIRTs), cell metabolism, and cancer. HDACs play a crucial role in the maintenance of epigenetic transcriptional regulation and seem to be involved in the pathogenesis of various metabolic and age-related disorders, including metabolic syndrome, several inflammatory, cardiovascular, and neurodegenerative conditions, and cancer. Recent insights have just started to outline the therapeutic potential of HDAC inhibitors (HDACi) not only in oncology, but also in the treatment of metabolic diseases. However, the links with energetic metabolism and metabolomics remain under-evaluated aspects in HDAC and HDACi research.
This Special Issue will be dedicated not only to in-depth applications of current metabolomics techniques to functional annotation of HDACs and characterization of HDACi, but also to cutting-edge drug and assay development for potential applications in metabolic conditions. The topics that we aim to cover with this Special Issue include the identification of novel metabolic functions and pathways affected by HDACi treatment, HDAC-related marker discovery for metabolic disease diagnosis and drug development, and metabolomics-driven studies that could help to shed light on the complex metabolic networks related to HDAC activity and inhibition. Manuscripts dealing with these or other challenging issues in the general context of metabolism and HDACs/HDACi will be highly appreciated.
Prof. Dr. Dante Rotili
Prof. Dr. Angela Nebbioso
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epigenetics
- metabolic diseases
- histone deacetylase (HDAC) inhibitors
- metabolomics
- drug discovery
