Metabolism and Immune Cell Function: Bridging the Gap between Systemic and Cellular Immunometabolism
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".
Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 298
Special Issue Editors
2. Li Ka Shing Institute of Virology, Edmonton, AB, Canada
Interests: immune dysregulation in metabolic diseases; immunometabolism; T and B cell metabolism; autoimmunity
2. BC Children’s Hospital Research institute, Vancouver, BC, Canada
3. Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada
Interests: immunometabolism; cellular metabolism; adoptive cellular therapy; T cell metabolism; innate immune cell metabolism; cancer immunology
Special Issue Information
Dear Colleagues,
Recent advances in the field of cellular immunometabolism have highlighted the intricate interconnections between intracellular metabolic pathways, immune cell fate, and immune cell function. Danger and antigenic signals activate immune cells and trigger a concurrent switch to increase metabolic demand. This is highly context dependent, since other extracellular signals, such as cytokines, chemokines, nutrient and oxygen availability and mechanical cues act as additional modifiers to fine-tune intracellular metabolism. Beyond tissue-specific metabolic environments, circulating immune cells are exposed to metabolite fluctuations caused by diet and inter-organ metabolite exchange. Disease-induced changes from steady-state metabolic homeostasis thus impact immune function and represent therapeutic targets for metabo-inflammatory disorders.
This Special Issue of Metabolites, “Metabolism and Immune cell function; Bridging the gap between systemic and cellular immunometabolism” will be dedicated to discussing recent advances in the fields of systemic and intracellular immunometabolism. We aim to provide a framework of our current understanding of homeostatic regulation of systemic and cellular metabolism, and highlight how this contributes to or is impacted by infection and disease. In this context, this issue aims to explore new opportunities where such pathways can be harnessed for immunomodulation and development of therapeutics.
Dr. Sue Tsai
Dr. Ramon Klein Geltink
Guest Editors
Manuscript Submission Information
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Keywords
- immunometabolism
- immune cell function
- metabolic diseases
- cellular metabolism
- tumour immunology
- imunotherapy
- adoptive cellular therapy
- metabolic intervention
