Metabolic Strategies in Hypoxia
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 26975
Special Issue Editors
Interests: hypoxia; ischemia; comparative neurophysiology; metabolism; thermoregulation
Interests: metabolic rate depression; anoxia tolerance; enzyme regulation; microRNA; epigenetics; freeze tolerance; estivation; hibernation
Special Issue Information
Dear Colleagues,
Hypoxia-tolerant organisms are adapted to thrive in challenging low-oxygen environments. These species commonly employ a combination of metabolic strategies to achieve this feat, including metabolic rate suppression, targeted switching of metabolic fuel substrate use, mobilization of metabolites, and/or elegant adaptations that either buffer or permit the accumulation of otherwise deleterious metabolic end products. This suite of metabolic adaptations is critical to both short- and long-term survival in hypoxic environments, and this Special Issue of Metabolites, entitled “Metabolic Strategies in Hypoxia”, will explore recent advances in our understanding of adaptive metabolic strategies, and of the underlying signaling pathways that mediate and coordinate these responses. Specific areas of interest include but are not limited to mechanisms underlying metabolic rate suppression, fuel switching, or other metabolic adaptations to hypoxia, regulation, and integration of these responses within the peripheral and central nervous systems, and in a systemic context, and exploration of the evolutionary origins of mechanisms of hypoxia tolerance.
Dr. Matthew Pamenter
Guest Editor
Manuscript Submission Information
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Keywords
- Metabolic rate suppression
- Alternative end products
- Alternative metabolic substrates
- Torpor
- Energetic trade-offs (e.g., thermogenesis vs. metabolic rate suppression)
- Oxygen conformer
- Comparative physiology