Genome-Scale Metabolic Models
A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Bioinformatics and Data Analysis".
Deadline for manuscript submissions: closed (15 June 2021)
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genome-scale metabolic models attempt to provide a representation of all biochemical reactions available to a given organism in a computer readable form. For the most part, such models are analyzed using techniques based on the fields of linear algebra and linear programming. In addition to providing a platform from which to investigate fundamental structural properties of these large and complex networks, they also find practical utility in fields of applied microbiology where they can, for example, be used for the design of genetic manipulation strategies, for defining novel media compositions, identifying maximum yields, or as potential targets for new antibiotic compounds. Although most work in the field is focused on prokaryotes, models have also been published for a variety of single and multicellular eukaryotes; the underlying principles remain the same, although eukaryotic models do pose a number of additional challenges. The objective of this Special Issue is twofold: firstly, to provide an overview and introduction to researchers who are new to the area, and secondly to provide a platform from which new models and algorithms can be presented.
Dr. Mark M.G. Poolman
Guest Editor
Manuscript Submission Information
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Keywords
- Metabolic modeling
- Genome-scale metabolic models
- Microbiology
- Biotechnology
- Flux balance analysis
- Computational biology