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Metabolites
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Metabolite Markers of Phytochemicals II
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Metabolite Markers of Phytochemicals II

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 7088

Special Issue Editor

Prof. Dr. Chi Chen

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Guest Editor
Section Editor, Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USA
Interests: animal nutrition; metabolomics; microbial metabolism; nutrient metabolism; nutritional biochemistry; xenobiotic metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemicals are indispensable natural components of human diet and animal feed. Besides being commonly used as dietary supplements and additives, bioactive phytochemicals are, in many cases, also potent pharmacological agents or their precursors. Benefits and adverse effects of bioactive phytochemicals are strongly associated with the bidirectional interactions between phytochemicals and the metabolic system, such as disposition of phytochemicals, regulation of nutrient, antioxidant, and microbial metabolism, and overdose-induced toxicities. Metabolites responsive to phytochemical exposure and treatments, such as their biotransformation products or the members of affected metabolic pathways, are potential markers of phytochemicals. This Special Issue aims to explore many aspects of these metabolite markers of phytochemicals, including identification, biosynthesis, significances, and applications of these metabolite markers in human and animal research. The coverage of this Special Issue includes, but is not limited to, the following topics:

  • Exposure markers and metabolic routes of phytochemicals
  • Effects of phytochemicals on digestion, absorption, distribution, and metabolism of nutrients and antioxidants
  • Interactions of phytochemicals with gut microbiota
  • Toxicities of phytochemicals
  • Interactions of phytochemicals with pharmacological agents

Dr. Chi Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemical
  • metabolite markers
  • metabolomics
  • microbiota
  • nutrient metabolism
  • xenobiotic metabolism

Published Papers (2 papers)

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Research

16 pages, 3573 KiB  
Article
Anti-Adipogenic Effect of Theabrownin Is Mediated by Bile Acid Alternative Synthesis via Gut Microbiota Remodeling
by Junliang Kuang, Xiaojiao Zheng, Fengjie Huang, Shouli Wang, Mengci Li, Mingliang Zhao, Chao Sang, Kun Ge, Yitao Li, Jiufeng Li, Cynthia Rajani, Xiaohui Ma, Shuiping Zhou, Aihua Zhao and Wei Jia
Metabolites 2020, 10(11), 475; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo10110475 - 23 Nov 2020
Cited by 35 | Viewed by 3616
Abstract
Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism. In this study, we demonstrated that [...] Read more.
Theabrownin is one of the most bioactive compounds in Pu-erh tea. Our previous study revealed that the hypocholesterolemic effect of theabrownin was mediated by the modulation of bile salt hydrolase (BSH)-enriched gut microbiota and bile acid metabolism. In this study, we demonstrated that theabrownin ameliorated high-fat-diet (HFD)-induced obesity by modifying gut microbiota, especially those with 7α-dehydroxylation on the species level, and these changed microbes were positively correlated with secondary bile acid (BA) metabolism. Thus, altered intestinal BAs resulted in shifting bile acid biosynthesis from the classic to the alternative pathway. This shift changed the BA pool by increasing non-12α-hydroxylated-BAs (non-12OH-BAs) and decreasing 12α-hydroxylated BAs (12OH-BAs), which improved energy metabolism in white and brown adipose tissue. This study showed that theabrownin was a potential therapeutic modality for obesity and other metabolic disorders via gut microbiota-driven bile acid alternative synthesis. Full article
(This article belongs to the Special Issue Metabolite Markers of Phytochemicals II)
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14 pages, 2485 KiB  
Article
Leaves and Spiny Burs of Castanea Sativa from an Experimental Chestnut Grove: Metabolomic Analysis and Anti-Neuroinflammatory Activity
by Ilaria Chiocchio, Cecilia Prata, Manuela Mandrone, Fortuna Ricciardiello, Pasquale Marrazzo, Paola Tomasi, Cristina Angeloni, Diana Fiorentini, Marco Malaguti, Ferruccio Poli and Silvana Hrelia
Metabolites 2020, 10(10), 408; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo10100408 - 13 Oct 2020
Cited by 22 | Viewed by 2824
Abstract
Castanea sativa cultivation has been present in Mediterranean regions since ancient times. In order to promote a circular economy, it is of great importance to valorize chestnut groves’ by-products. In this study, leaves and spiny burs from twenty-four Castanea trees were analyzed by [...] Read more.
Castanea sativa cultivation has been present in Mediterranean regions since ancient times. In order to promote a circular economy, it is of great importance to valorize chestnut groves’ by-products. In this study, leaves and spiny burs from twenty-four Castanea trees were analyzed by 1H NMR metabolomics to provide an overview of their phytochemical profile. The Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) performed on these data allowed us to distinguish ‘Marrone’ from ‘Castagna’, since the latter were generally more enriched with secondary metabolites, in particular, flavonoids (astragalin, isorhamnetin glucoside, and myricitrin) were dominant. Knowing that microglia are involved in mediating the oxidative and inflammatory response of the central nervous system, the potential anti-inflammatory effects of extracts derived from leaves and spiny burs were evaluated in a neuroinflammatory cell model: BV-2 microglia cells. The tested extracts showed cytoprotective activity (at 0.1 and 0.5 mg/mL) after inflammation induction by 5 µg/mL lipopolysaccharide (LPS). In addition, the transcriptional levels of IL-1β, TNF-α, and NF-kB expression induced by LPS were significantly decreased by cell incubation with spiny burs and leaves extracts. Taken together, the obtained results are promising and represent an important step to encourage recycling and valorization of chestnut byproducts, usually considered “waste”. Full article
(This article belongs to the Special Issue Metabolite Markers of Phytochemicals II)
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