Special Issue "Sports and Health Metabolism"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (31 March 2021).

Special Issue Editors

Prof. Dr. Johannes Scherr
E-Mail Website
Guest Editor
University Center for Prevention and Sports Medicine, Balgrist University Hospital, University of Zurich, Zürich, Switzerland
Interests: Johannes Scherr's primary research topic is the effects of extreme physical strain (e.g. marathon) on various organs, in particular the immune and cardiovascular systems and metabolism. Furthermore, the effects and possible applications of nutrition.

Special Issue Information

Dear Colleagues,

Sport, health, and metabolism have a close physiological and clinical relationship. These three fields of scientific endeavor are inextricably interwoven, and this Special Issue of Metabolites will include articles that provide novel insights into how exercise and athletic endeavor influence health and metabolism.

Technological advances have accelerated scientific discoveries in these areas, and include genomics, metabolomics, proteomics, lipidomics, and gut microbiome characterization. These multi-omics approaches provide a systemwide view of the multifaceted health and metabolic responses to exercise by simultaneously measuring and identifying large numbers of small-molecule metabolites, lipids, proteins, and other molecules. Exhalomics is an innovative approach that noninvasively measures hundreds of metabolic molecules from exhaled breath samples. These data are providing new insights with the potential to improve personalized lifestyle and medical guidance.

This Special Issue will advance scientific understanding in sport, health, and metabolism, with an emphasis on multi-omics approaches. We look forward to reviewing your papers.

Prof. Dr. Johannes Scherr
Prof. Dr. David C. Nieman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metabolomics
  • Exhalomics
  • Exercise
  • Athlete
  • Health
  • Proteomics
  • Lipidomics
  • Genomics
  • Sport
  • Metabolism
  • Microbiome

Published Papers (1 paper)

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Research

Article
Improved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis
Metabolites 2021, 11(4), 247; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11040247 - 16 Apr 2021
Viewed by 777
Abstract
Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by a lack of dystrophin expression in the sarcolemma of muscle fibers. DMD patients acquire bone abnormalities including osteopenia, fragility fractures, and scoliosis indicating a deficiency in skeletal homeostasis. The dKO (dystrophin/Utrophin double [...] Read more.
Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by a lack of dystrophin expression in the sarcolemma of muscle fibers. DMD patients acquire bone abnormalities including osteopenia, fragility fractures, and scoliosis indicating a deficiency in skeletal homeostasis. The dKO (dystrophin/Utrophin double knockout) is a more severe mouse model of DMD than the mdx mouse (dystrophin deficient), and display numerous clinically-relevant manifestations, including a spectrum of degenerative changes outside skeletal muscle including bone, articular cartilage, and intervertebral discs. To examine the influence of systemic factors on the bone abnormalities and healing in DMD, parabiotic pairing between dKO mice and mdx mice was established. Notably, heterochronic parabiosis with young mdx mice significantly increased bone mass and improved bone micro-structure in old dKO-hetero mice, which showed progressive bone deterioration. Furthermore, heterochronic parabiosis with WT C56/10J mice significantly improved tibia bone defect healing in dKO-homo mice. These results suggest that systemic blood-borne factor(s) and/or progenitors from WT and young mdx mice can influence the bone deficiencies in dKO mice. Understanding these circulating factors or progenitor cells that are responsible to alleviate the bone abnormalities in dKO mice after heterochronic parabiosis might be useful for the management of poor bone health in DMD. Full article
(This article belongs to the Special Issue Sports and Health Metabolism)
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