Skeletal Muscle Metabolism after Stroke

Dear Colleagues,

It is well established that a stroke is one of the leading causes of disability. The incidence of stroke is expected to continue rising and despite advanced medical management, many stroke survivors have residual deficits. After a stroke, the progression and consequences of muscle wasting may be compounded by relative inactivity, reduced strength, and low fitness levels. In addition to these, skeletal muscle following stroke may be affected by the altered central neural activation and spasticity and lead to alterations in the molecular, metabolic and functional properties of skeletal muscle, potentially influencing whole body and cellular metabolism. These biological processes in muscle have clinical relevance to the health of stroke survivors.

This special issue of Metabolites. “Skeletal Muscle Metabolism after Stroke” will be dedicated to informing readership on the ensuing effects of a stroke on skeletal muscle and invites a variety of multidisciplinary scientists to submit their work on this topic. This issue will provide the reader with significant and novel findings to advance the science of changes in skeletal muscle after stroke both in the acute hospital setting or in the chronic phase, as well as how therapy or behavioral interventions may mitigate or alter skeletal muscle and metabolism in persons who have had a stroke. The topics that the special issue will cover include a) changes in skeletal muscle with aging after stroke, altered muscle phenotype, paretic and non-paretic comparisons; b) metabolic changes, inflammation, biomarkers in the circulation linked to changes in stroke skeletal muscle; c) influence of a stroke on body composition, sarcopenia, frailty, and associated age-related loss of muscle mass and physical function; d) mechanistic insight of stroke on skeletal muscle including muscle fiber typing, inflammation, mitochondrial function, DNA methylation profiles or the epigenetic regulation of numerous genes; and e) role of nutrition and/or behavioral interventions on muscle quality (mass, strength, composition/intramuscular fat) in stroke survivors. Manuscripts dealing with other topics not mentioned but related to this topic are also highly desired.

Dr. Alice S. Ryan
Guest Editor

Manuscript Submission Information

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