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Metabolites and Metabolic Regulation in the Nematode Nervous System: Behavior...
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Metabolites and Metabolic Regulation in the Nematode Nervous System: Behavior and Ecology

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5201

Special Issue Editor

Dr. Jin I. Lee

E-Mail Website1 Website2
Guest Editor
Division of Biological Science and Technology, Yonsei University Mirae Campus, Wonju 220710, Korea
Interests: C. elegans; behavior; ecology; neurobiology; genetics; gravity; space; olfaction

Special Issue Information

Dear Colleagues,

Over the last several decades, genetic studies using the model organism Caenorhabditis elegans have revealed cellular and molecular mechanisms of physiology, behavior, and metabolism in the nematode. The nematode also provides us with a simple model to study biological interactions at higher levels within the nematode, between nematodes, and between the nematode and its natural ecological environments. Studies are beginning to focus on the biology of metabolism and metabolites at these higher and broader levels, particularly how they affect the nematode nervous system and behavior and even reproductive fitness at the ecological level. The goal of this Special Issue of Metabolites, entitled Metabolites and Metabolic Regulation in the Nematode Nervous System: Behavior and Ecology, is to answer some of these questions in order that we may come to a better understanding of how metabolites and metabolic regulation can affect animal behavior and ecology. The topics covered in this issue include: nematode and microbial metabolic regulation, nematode pheromones and other secreted small molecules, nematode and microbial nutrition, microbial metabolites, microbial odors and other chemicals, microbiome, microbial pathogenesis, nematode and microbial metabolomics, animal and plant metabolites of pathogenic nematode hosts, etc.

Dr. Jin I. Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nematode
  • C. elegans
  • behavior
  • ecology
  • nervous system
  • neuron
  • sensory
  • olfaction

Published Papers (3 papers)

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Research

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14 pages, 1509 KiB  
Article
Neurobiological Basis of Aversion-Resistant Ethanol Seeking in C. elegans
by Changhoon Jee, Enkhzul Batsaikhan and Chinnu Salim
Metabolites 2023, 13(1), 62; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo13010062 - 31 Dec 2022
Cited by 2 | Viewed by 1489
Abstract
Persistent alcohol seeking despite the risk of aversive consequences is a crucial characteristic of alcohol use disorders (AUDs). Therefore, an improved understanding of the molecular basis of alcohol seeking despite aversive stimuli or punishment in animal models is an important strategy to understand [...] Read more.
Persistent alcohol seeking despite the risk of aversive consequences is a crucial characteristic of alcohol use disorders (AUDs). Therefore, an improved understanding of the molecular basis of alcohol seeking despite aversive stimuli or punishment in animal models is an important strategy to understand the mechanism that underpins the pathology of AUDs. Aversion-resistant seeking (ARS) is characterized by disruption in control of alcohol use featured by an imbalance between the urge for alcohol and the mediation of aversive stimuli. We exploited C. elegans, a genetically tractable invertebrate, as a model to elucidate genetic components related to this behavior. We assessed the seb-3 neuropeptide system and its transcriptional regulation to progress aversion-resistant ethanol seeking at the system level. Our functional genomic approach preferentially selected molecular components thought to be involved in cholesterol metabolism, and an orthogonal test defined functional roles in ARS through behavioral elucidation. Our findings suggest that fmo-2 (flavin-containing monooxygenase-2) plays a role in the progression of aversion-resistant ethanol seeking in C. elegans. Full article
(This article belongs to the Special Issue Metabolites and Metabolic Regulation in the Nematode Nervous System: Behavior and Ecology)
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12 pages, 2809 KiB  
Article
BAM15 Relieves Neurodegeneration in Aged Caenorhabditis elegans and Extends Lifespan
by Injeong Cho, Hyun-Ok Song, Ha Eun Ji, Sungtae Yang and Jeong Hoon Cho
Metabolites 2022, 12(11), 1129; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12111129 - 17 Nov 2022
Cited by 5 | Viewed by 1799
Abstract
BAM15 was recently screened as a protonophore uncoupler specifically for the mitochondrial membrane but not the plasma membrane. It is equally as potent as FCCP, but less toxic. Previously, mitochondrial uncoupling via DNP alleviates neurodegeneration in the nematode Caenorhabditis elegans during aging. Therefore, [...] Read more.
BAM15 was recently screened as a protonophore uncoupler specifically for the mitochondrial membrane but not the plasma membrane. It is equally as potent as FCCP, but less toxic. Previously, mitochondrial uncoupling via DNP alleviates neurodegeneration in the nematode Caenorhabditis elegans during aging. Therefore, we investigated whether BAM15 uncouplers could phenotypically and functionally reduce neuronal defects in aged nematodes. We observed green fluorescence protein-tagged mechanosensory neurons and performed touch and chemotaxis assays during aging. Wild-type animals treated with both 50 µM BAM15 and 10 µM DNP showed reduced mechanosensory neuronal defects during aging, which correlates with the maintenance of touch responses and short-term memory during aging. Uncoupler mutant ucp-4 also responded the same way as the wild-type, reducing neurodegeneration in 50 µM BAM15 and 10 µM DNP-treated animals compared to the DMSO control. These results suggest that 50 µM BAM15 alleviates neurodegeneration phenotypically and functionally in C. elegans during aging, potentially through mitochondrial uncoupling. In accordance with the preserved neuronal shape and function in aged C. elegans, 50 µM BAM15 extended the mean lifespan of both wild-type and ucp-4 mutants. Full article
(This article belongs to the Special Issue Metabolites and Metabolic Regulation in the Nematode Nervous System: Behavior and Ecology)
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Review

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13 pages, 318 KiB  
Review
Making “Sense” of Ecology from a Genetic Perspective: Caenorhabditis elegans, Microbes and Behavior
by Kyoung-hye Yoon, Rocel Amor Indong and Jin I. Lee
Metabolites 2022, 12(11), 1084; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12111084 - 09 Nov 2022
Cited by 1 | Viewed by 1385
Abstract
Our knowledge of animal and behavior in the natural ecology is based on over a century’s worth of valuable field studies. In this post-genome era, however, we recognize that genes are the underpinning of ecological interactions between two organisms. Understanding how genes contribute [...] Read more.
Our knowledge of animal and behavior in the natural ecology is based on over a century’s worth of valuable field studies. In this post-genome era, however, we recognize that genes are the underpinning of ecological interactions between two organisms. Understanding how genes contribute to animal ecology, which is essentially the intersection of two genomes, is a tremendous challenge. The bacterivorous nematode Caenorhabditis elegans, one of the most well-known genetic animal model experimental systems, experiences a complex microbial world in its natural habitat, providing us with a window into the interplay of genes and molecules that result in an animal–microbial ecology. In this review, we will discuss C. elegans natural ecology, how the worm uses its sensory system to detect the microbes and metabolites that it encounters, and then discuss some of the fascinating ecological dances, including behaviors, that have evolved between the nematode and the microbes in its environment. Full article
(This article belongs to the Special Issue Metabolites and Metabolic Regulation in the Nematode Nervous System: Behavior and Ecology)
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