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Metabolites
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Metabolites Produced by Yeast Cells
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Metabolites Produced by Yeast Cells

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 14242

Special Issue Editor

Dr. Marek Kieliszek

E-Mail Website
Guest Editor
Faculty of Food Sciences, Department of Biotechnology, Microbiology and Food Evaluation, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159 C, 02-776 Warsaw, Poland
Interests: biotechnology; microbiology; cancer; bacteria; selenium; biochemistry; yeast; food industry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Yeasts have various biotechnological applications in various branches of the industry. Due to its characteristics and ease of application, yeast biomass is increasingly becoming popular among the scientific community. A great advantage of yeast production is their ability to grow on waste products obtained from various industries. Yeasts find greater application in modern biotechnology. They do not have high nutritional requirements and exhibit fast growth rate and are widely used in various branches of the industry. They have successfully found application in food, medical, or pharmaceutical industries. The large-scale production of yeast biomass rich in individual metabolites has many advantages. It can be obtained using simple techniques and with the use of waste products generated from various industries. Due to their exceptional metabolic activity, yeasts are capable of assimilating different sources of carbon and nitrogen. This Special Issue is devoted to reviewing the current aspects of yeast biotechnology, genetics, and proteomics. Moreover, we note the potential of these microorganisms as a source of microbial protein and polysaccharides in human and animal nutrition. We also encourage you to submit articles on the possibility of biosynthesis by yeast of various metabolites (for example, xylitol, erythritol, lipids, citric acid, and many others).

Dr. Marek Kieliszek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • yeast
  • biotechnology
  • yeast metabolic pathways
  • metabolic engineering
  • natural products in yeast
  • screening for genes
  • yeast proteome

Published Papers (4 papers)

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Research

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17 pages, 1587 KiB  
Article
Selection of Potential Yeast Probiotics and a Cell Factory for Xylitol or Acid Production from Honeybee Samples
by Farah Zahoor, Chayaphathra Sooklim, Pattanan Songdech, Orawan Duangpakdee and Nitnipa Soontorngun
Metabolites 2021, 11(5), 312; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11050312 - 13 May 2021
Cited by 14 | Viewed by 3232
Abstract
Excessive use of antibiotics has detrimental consequences, including antibiotic resistance and gut microbiome destruction. Probiotic-rich diets help to restore good microbes, keeping the body healthy and preventing the onset of chronic diseases. Honey contains not only prebiotic oligosaccharides but, like yogurt and fermented [...] Read more.
Excessive use of antibiotics has detrimental consequences, including antibiotic resistance and gut microbiome destruction. Probiotic-rich diets help to restore good microbes, keeping the body healthy and preventing the onset of chronic diseases. Honey contains not only prebiotic oligosaccharides but, like yogurt and fermented foods, is an innovative natural source for probiotic discovery. Here, a collection of three honeybee samples was screened for yeast strains, aiming to characterize their potential in vitro probiotic properties and the ability to produce valuable metabolites. Ninety-four isolates out of one-hundred and four were able to grow at temperatures of 30 °C and 37 °C, while twelve isolates could grow at 42 °C. Fifty-eight and four isolates displayed the ability to grow under stimulated gastrointestinal condition, at pH 2.0–2.5, 0.3% (w/v) bile salt, and 37 °C. Twenty-four isolates showed high autoaggregation of 80–100% and could utilize various sugars, including galactose and xylose. The cell count of these isolates (7–9 log cfu/mL) was recorded and stable during 6 months of storage. Genomic characterization based on the internal transcribed spacer region (ITS) also identified four isolates of Saccharomyces cerevisiae displayed good ability to produce antimicrobial acids. These results provided the basis for selecting four natural yeast isolates as starter cultures for potential probiotic application in functional foods and animal feed. Additionally, these S. cerevisiae isolates also produced high levels of acids from fermented sugarcane molasses, an abundant agricultural waste product from the sugar industry. Furthermore, one of ten identified isolates of Meyerozyma guilliermondiii displayed an excellent ability to produce a pentose sugar xylitol at a yield of 0.490 g/g of consumed xylose. Potentially, yeast isolates of honeybee samples may offer various biotechnological advantages as probiotics or metabolite producers of multiproduct-based lignocellulosic biorefinery. Full article
(This article belongs to the Special Issue Metabolites Produced by Yeast Cells)
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14 pages, 3548 KiB  
Article
Metabolomic Analysis of Response to Nitrogen-Limiting Conditions in Yarrowia spp.
by Sivamoke Dissook, Sastia Prama Putri and Eiichiro Fukusaki
Metabolites 2021, 11(1), 16; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11010016 - 29 Dec 2020
Cited by 4 | Viewed by 2112
Abstract
Yarrowia is a yeast genus that has been used as a model oleaginous taxon for a wide array of studies. However, information regarding metabolite changes within Yarrowia spp. under different environmental conditions is still limited. Among various factors affecting Yarrowia metabolism, nitrogen-limiting conditions [...] Read more.
Yarrowia is a yeast genus that has been used as a model oleaginous taxon for a wide array of studies. However, information regarding metabolite changes within Yarrowia spp. under different environmental conditions is still limited. Among various factors affecting Yarrowia metabolism, nitrogen-limiting conditions have a profound effect on the metabolic state of yeast. In this study, a time-course LC-MS/MS-based metabolome analysis of Y. lipolytica was performed to determine the optimal cultivation time and carbon-to-nitrogen ratio for studying the effects of nitrogen-limiting conditions on Yarrowia; we found that cultivation time of 36 h and carbon-to-nitrogen ratio of 4:1 and 5:0 was suitable for studying the effects of nitrogen-limiting conditions on Yarrowia and these conditions were applied to six strains of Yarrowia. These six strains of Yarrowia showed similar responses to nitrogen-limiting conditions; however, each strain had a unique metabolomic profile. Purine and pyrimidine metabolism were the most highly affected biological pathways in nitrogen-limiting conditions, indicating that these conditions affect energy availability within cells. This stress leads to a shift in cells to the utilization of a less ATP-dependent biological pathway. This information will be beneficial for the development of Yarrowia strains for further scientific and industrial applications. Full article
(This article belongs to the Special Issue Metabolites Produced by Yeast Cells)
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13 pages, 890 KiB  
Article
A New Approach for the Production of Selenium-Enriched and Probiotic Yeast Biomass from Agro-Industrial by-Products in a Stirred-Tank Bioreactor
by Sabrina Evelin Martiniano, Letícia Alves Fernandes, Edith Mier Alba, Rafael Rodrigues Philippini, Stephanie Caroline Tavares Tabuchi, Marek Kieliszek, Júlio César dos Santos and Silvio Silvério da Silva
Metabolites 2020, 10(12), 508; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo10120508 - 13 Dec 2020
Cited by 4 | Viewed by 2643
Abstract
The production of biomolecules using agro-industrial by-products as feedstock is a growing trend worldwide. Selenium (Se) is a trace element essential for health, and the Se-enrichment of yeast biomass can enhance its benefits. This study investigated the feasibility of the production of Saccharomyces [...] Read more.
The production of biomolecules using agro-industrial by-products as feedstock is a growing trend worldwide. Selenium (Se) is a trace element essential for health, and the Se-enrichment of yeast biomass can enhance its benefits. This study investigated the feasibility of the production of Saccharomyces cerevisiae Se-enriched biomass using a medium composed of corn bran and soybean bran acid hydrolysates as carbon and nitrogen sources in a stirred-tank reactor. After hydrolysis, hydrolysates presented complex composition and high concentrations of sugars, proteins, and minerals. The use of a stirred-tank bioreactor leads to the production of 9 g/L S. cerevisiae biomass enriched with 236.93 μg/g Se, and 99% cell viability. Likewise, the combination of sugarcane molasses and soybean bran hydrolysate was effective for cell growth of a probiotic strain of S. cerevisiae with a 24.08% β-glucan content. The results demonstrated that starchy acid hydrolysates are low-cost and efficient substrates for the production of yeast biomass and derivate products and may contribute to further studies for a sustainable development of biorefinery technologies. Full article
(This article belongs to the Special Issue Metabolites Produced by Yeast Cells)
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Review

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17 pages, 1786 KiB  
Review
Carotenoids and Some Other Pigments from Fungi and Yeasts
by Alexander Rapoport, Irina Guzhova, Lorenzo Bernetti, Pietro Buzzini, Marek Kieliszek and Anna Maria Kot
Metabolites 2021, 11(2), 92; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11020092 - 06 Feb 2021
Cited by 50 | Viewed by 5365
Abstract
Carotenoids are an essential group of compounds that may be obtained by microbiological synthesis. They are instrumental in various areas of industry, medicine, agriculture, and ecology. The increase of carotenoids’ demand at the global market is now essential. At the moment, the production [...] Read more.
Carotenoids are an essential group of compounds that may be obtained by microbiological synthesis. They are instrumental in various areas of industry, medicine, agriculture, and ecology. The increase of carotenoids’ demand at the global market is now essential. At the moment, the production of natural carotenoids is more expensive than obtaining their synthetic forms, but several new approaches/directions on how to decrease this difference were developed during the last decades. This review briefly describes the information accumulated until now about the beneficial effects of carotenoids on human health protection, their possible application in the treatments of various diseases, and their use in the food and feed industry. This review also describes some issues that are linked with biotechnological production of fungal and yeasts carotenoids, as well as new approaches/directions to make their biotechnological production more efficient. Full article
(This article belongs to the Special Issue Metabolites Produced by Yeast Cells)
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