Special Issue "Micro-Scale Approaches in Regenerative Medicine and Tissue Engineering: Advances and Challenges"

A special issue of Micro (ISSN 2673-8023). This special issue belongs to the section "Microscale Biology and Medicines".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Valeria Chiono
E-Mail Website
Guest Editor
Prof. Dr. Irene Carmagnola
E-Mail Website
Guest Editor
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Turin, Italy
Interests: tissue engineering; scaffold; hydrogels; drug release
Special Issues and Collections in MDPI journals
Dr. Alice Zoso
Guest Editor
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129, Turin, Italy
Interests: tissue engineering; 3D cultures; in vitro tissue models
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The field of tissue engineering and regenerative medicine (TERM) has dramatically advanced in the last 20 years, giving the potential for regenerating almost every tissue and organ of the human body. TERM aims at the design of functional three-dimensional constructs able to properly guide cell behavior for tissue/organ regeneration or modelling.

Human tissues are complex systems comprising cells subjected to multiple and dynamic stimuli that change in time and space. Typical signals are direct cell–cell contacts, gradients of cytokines and secreted proteins from neighboring cells, and biochemical and mechanical interactions with the extracellular matrix (ECM). Different organs and tissues are characterized by a hierarchical structure with complex organization of these elements, giving rise to unique arrangements.

TERM has taken advantage of an interdisciplinary approach involving aspects of cell biology, biomaterials science, surface functionalization and characterization, and cell–material interactions often integrated in microfabricated systems to accurately reproduce the complexity of in vivo microenvironments, including ECM organization and other tissue features (e.g., electrical stimuli, mechanical stress). The microscale design of cell culture environments has the potential to allow controllable and reproducible cell organization following tissue-specific cues.

The topics to be covered in this issue include advanced microtechnologies applied to the TERM field, such as the following:

  • microhydrogel
  • microfluidic systems
  • micro-controlled surface and interface pattern
  • microbioreactors
  • microfabrication of 2D and 3D scaffolds
  • micro-carriers for drug release
  • micro-systems for the cell adhesion
  • single-cell stimulation
  • cell microenvironments

You may choose our Joint Special Issue in IJMS.

Prof. Dr. Valeria Chiono
Prof. Dr. Irene Carmagnola
Dr. Alice Zoso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micro is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • microscale
  • scaffold
  • TERM
  • surface characterization
  • hydrogel
  • drug release
  • biomimetics

Published Papers

This special issue is now open for submission.
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