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Microarrays
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Carbohydrate Microarrays
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Carbohydrate Microarrays

A special issue of Microarrays (ISSN 2076-3905).

Deadline for manuscript submissions: closed (31 August 2015) | Viewed by 14092

Special Issue Editor

Dr. Yan Liu

E-Mail Website
Guest Editor
The Glycosciences Laboratory, Department of Medicine, Imperial College London, Hammersmith Campus, London, UK
Interests: carbohydrate (glycan) microarray technology; carbohydrate-protein interactions; pathogen-host interactions; carbohydrate ligand discovery; disease-specific carbohydrate-based biomarkers; chemo-enzymatic synthesis of carbohydrates

Special Issue Information

Dear Colleagues,

Glycoscience, a field that explores the structures and functions of glycans (also known as carbohydrates or saccharides),  has been recognized to hold great promises in divers areas, including biology, medicine, energy generation, and material sciences. Over the last decade carbohydrate microarrays have become essential tools in the field and are revolutionizing the unravelling of carbohydrate–protein interactions in health and disease processes. This special issue will cover several carbohydrate microarray platforms with differing immobilization or detection methodologies, and their applications in studies of diverse carbohydrate recognition systems, including immune lectins, pathogens and anti-cancer antibodies. Hopefully it will find readers in the glyco field and also outside the research area.

This special issue also attempts to highlight some of the interesting topics in the carbohydrate microarray technology, such as the importance of density and presentation of glycan probes for recognition, and the need for having an international carbohydrate microarray database to store and make available to broad scientific community microarray data from highly complementary platforms.

With best regards,

Dr. Yan Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microarrays is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Published Papers (2 papers)

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Review

758 KiB  
Review
Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses
by Tania M. Puvirajesinghe and Jeremy. E. Turnbull
Microarrays 2016, 5(1), 3; https://0-doi-org.brum.beds.ac.uk/10.3390/microarrays5010003 - 04 Jan 2016
Cited by 20 | Viewed by 6779
Abstract
Microarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate array technology was hindered by the complex structures of glycans and their structural variability. The first designs of glycoarrays focused on the HTP (high throughput) study of protein–glycan binding events, and subsequently more [...] Read more.
Microarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate array technology was hindered by the complex structures of glycans and their structural variability. The first designs of glycoarrays focused on the HTP (high throughput) study of protein–glycan binding events, and subsequently more in-depth kinetic analysis of carbohydrate–protein interactions. However, the applications have rapidly expanded and now achieve successful discrimination of selective interactions between carbohydrates and, not only proteins, but also viruses, bacteria and eukaryotic cells, and most recently even live cell responses to immobilized glycans. Combining array technology with other HTP technologies such as mass spectrometry is expected to allow even more accurate and sensitive analysis. This review provides a broad overview of established glycoarray technologies (with a special focus on glycosaminoglycan applications) and their emerging applications to the study of complex interactions between glycans and whole living cells. Full article
(This article belongs to the Special Issue Carbohydrate Microarrays)
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1613 KiB  
Review
Assessing Bacterial Interactions Using Carbohydrate-Based Microarrays
by Andrea Flannery, Jared Q. Gerlach, Lokesh Joshi and Michelle Kilcoyne
Microarrays 2015, 4(4), 690-713; https://0-doi-org.brum.beds.ac.uk/10.3390/microarrays4040690 - 10 Dec 2015
Cited by 11 | Viewed by 7070
Abstract
Carbohydrates play a crucial role in host-microorganism interactions and many host glycoconjugates are receptors or co-receptors for microbial binding. Host glycosylation varies with species and location in the body, and this contributes to species specificity and tropism of commensal and pathogenic bacteria. Additionally, [...] Read more.
Carbohydrates play a crucial role in host-microorganism interactions and many host glycoconjugates are receptors or co-receptors for microbial binding. Host glycosylation varies with species and location in the body, and this contributes to species specificity and tropism of commensal and pathogenic bacteria. Additionally, bacterial glycosylation is often the first bacterial molecular species encountered and responded to by the host system. Accordingly, characterising and identifying the exact structures involved in these critical interactions is an important priority in deciphering microbial pathogenesis. Carbohydrate-based microarray platforms have been an underused tool for screening bacterial interactions with specific carbohydrate structures, but they are growing in popularity in recent years. In this review, we discuss carbohydrate-based microarrays that have been profiled with whole bacteria, recombinantly expressed adhesins or serum antibodies. Three main types of carbohydrate-based microarray platform are considered; (i) conventional carbohydrate or glycan microarrays; (ii) whole mucin microarrays; and (iii) microarrays constructed from bacterial polysaccharides or their components. Determining the nature of the interactions between bacteria and host can help clarify the molecular mechanisms of carbohydrate-mediated interactions in microbial pathogenesis, infectious disease and host immune response and may lead to new strategies to boost therapeutic treatments. Full article
(This article belongs to the Special Issue Carbohydrate Microarrays)
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