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Micromachines
Special Issues
Fabrication of Extracellular Matrix Microenvironment with 3D Bioprinting Technology
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Fabrication of Extracellular Matrix Microenvironment with 3D Bioprinting Technology

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 6502

Special Issue Editors

Dr. Guoliang Ying

E-Mail Website
Guest Editor
Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
Interests: biomaterials; 3D bioprinting
Dr. Nan Jiang

E-Mail Website
Guest Editor
Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China
Interests: biomaterials; biosensors

Special Issue Information

Dear Colleagues,

Three-dimensional bioprinting technology provides programmable and customizable platforms with which to engineer cell-laden constructs mimicking human tissues for a wide range of biomedical applications. The requirements for an extracellular matrix microenvironment suitable for cell growth are extremely strict. For example, cells require an aqueous environment, sufficient oxygen and nutrient diffusion, and an appropriate pH and osmolarity, along with key vitamins and minerals for cellular functions. Furthermore, certain cell types require specific cell attachment sites and substrate properties to proliferate. Additionally, cells must have room to create a new extracellular matrix, which means that printed materials should degrade into non-toxic components over time to promote new tissue formation. However, considering the complexity of the structures and functions of tissues or organs, it remains a challenge to fabricate an extracellular matrix microenvironment very close to the native environment. It is necessary to employ advanced bioinks with advanced bioprinting technology as a next-generation additive manufacturing technology to fabricate an extracellular matrix microenvironment that maximally emulates its native counterparts. Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments in bioink and bioprinting technology related to the fabrication of extracellular matrix microenvironments.

We look forward to receiving your submissions!

Dr. Guoliang Ying
Dr. Nan Jiang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioink
  • bioprinting
  • biomaterial
  • biofabrication tissue engineering

Published Papers (2 papers)

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Review

17 pages, 2279 KiB  
Review
Application of 3D Bioprinting in Urology
by Yue Zhao, Yuebai Liu, Yi Dai, Luo Yang and Guo Chen
Micromachines 2022, 13(7), 1073; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13071073 - 07 Jul 2022
Cited by 7 | Viewed by 2550
Abstract
Tissue engineering is an emerging field to create functional tissue components and whole organs. The structural and functional defects caused by congenital malformation, trauma, inflammation or tumor are still the major clinical challenges facing modern urology, and the current treatment has not achieved [...] Read more.
Tissue engineering is an emerging field to create functional tissue components and whole organs. The structural and functional defects caused by congenital malformation, trauma, inflammation or tumor are still the major clinical challenges facing modern urology, and the current treatment has not achieved the expected results. Recently, 3D bioprinting has gained attention for its ability to create highly specialized tissue models using biological materials, bridging the gap between artificially engineered and natural tissue structures. This paper reviews the research progress, application prospects and current challenges of 3D bioprinting in urology tissue engineering. Full article
(This article belongs to the Special Issue Fabrication of Extracellular Matrix Microenvironment with 3D Bioprinting Technology)
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22 pages, 2817 KiB  
Review
Photo-Crosslinkable Hydrogels for 3D Bioprinting in the Repair of Osteochondral Defects: A Review of Present Applications and Future Perspectives
by Gang Tan, Jing Xu, Qin Yu, Jieyu Zhang, Xuefeng Hu, Chenwei Sun and Hui Zhang
Micromachines 2022, 13(7), 1038; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13071038 - 29 Jun 2022
Cited by 8 | Viewed by 3401
Abstract
An osteochondral defect is a common and frequent disease in orthopedics and treatment effects are not good, which can be harmful to patients. Hydrogels have been applied in the repair of cartilage defects. Many studies have reported that hydrogels can effectively repair osteochondral [...] Read more.
An osteochondral defect is a common and frequent disease in orthopedics and treatment effects are not good, which can be harmful to patients. Hydrogels have been applied in the repair of cartilage defects. Many studies have reported that hydrogels can effectively repair osteochondral defects through loaded cells or non-loaded cells. As a new type of hydrogel, photo-crosslinked hydrogel has been widely applied in more and more fields. Meanwhile, 3D bioprinting serves as an attractive platform to fabricate customized tissue-engineered substitutes from biomaterials and cells for the repair or replacement of injured tissues and organs. Although photo-crosslinkable hydrogel-based 3D bioprinting has some advantages for repairing bone cartilage defects, it also has some disadvantages. Our aim of this paper is to review the current status and prospect of photo-crosslinkable hydrogel-based 3D bioprinting for repairing osteochondral defects. Full article
(This article belongs to the Special Issue Fabrication of Extracellular Matrix Microenvironment with 3D Bioprinting Technology)
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