Optofluidic Transducers: Microfluidic Devices Incorporating Optical/Photonic Sensing Capabilities

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "A:Physics".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 7237

Special Issue Editors


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Guest Editor
Technische Universität, Ilmenau, Germany

Special Issue Information

Dear Colleagues,

Optofluidic devices are of high scientific and industrial interest in chemistry, biology, material science, pharmacy, or medicine. In recent years, they have experienced a strong development because of impressive achievements of the synergistic combination of photonics and micro/nanofluidics. The key elements of these devices are their transducers that transform the slightest changes in a media in a quantifiable optical signal.

Thus, sensing platforms incorporating these optofluidic transducers show unprecedented sensitivities in extremely small analyte volumes, and allow real time analysis within a lab-on-a-chip approach. Many of them are based on the interaction of fluids with evanescent waves induced at metal/dielectric interfaces, at the surface of truncated photonic crystals, at integrated Mach-Zehnder interferometers, on the use of plasmonic filters based on the extraordinary optical transmission, or on the implementation of microcavities to induce optical resonances in fluid media.

In this context, a large variety of optofluidic transducers have emerged, covering topics such as bio-sensing, water analysis/environmental monitoring, liquid agrofood safety, catalytic reactions, microparticle sorting, medical diagnostic technologies, drug discovery, or micro-imaging. Moreover, integration of these devices in larger electro-optic platforms represents a highly valuable improvement towards advanced applications, such as those based on surface plasmon resonances, already in the market.

In this Special Issue, we invite the scientific community working in this rapidly evolving field to publish recent research and/or review papers on these optofluidic transducers.

Prof. Francisco Yubero
Dr. Manuel Manuel Oliva-Ramírez
Guest Editors

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Keywords

  • Microfluidics
  • Lab-on-a-chip
  • Optical bio-sensing
  • Surface plasmon resonance
  • Bloch surface waves
  • Evanescent wave physics
  • Fabry-Perot microcavities
  • Mach-Zehnder interferometers
  • Fluorescence imaging
  • On-chip microscopy
  • Optical gas/vapor sensors
  • Chiral detection
  • Microring resonators

Published Papers (1 paper)

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Review

42 pages, 8565 KiB  
Review
A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices
by Mahmudur Rahman, Kazi Rafiqul Islam, Md. Rashedul Islam, Md. Jahirul Islam, Md. Rejvi Kaysir, Masuma Akter, Md. Arifur Rahman and S. M. Mahfuz Alam
Micromachines 2022, 13(6), 968; https://0-doi-org.brum.beds.ac.uk/10.3390/mi13060968 - 18 Jun 2022
Cited by 3 | Viewed by 6661
Abstract
Single-molecule techniques have shifted the paradigm of biological measurements from ensemble measurements to probing individual molecules and propelled a rapid revolution in related fields. Compared to ensemble measurements of biomolecules, single-molecule techniques provide a breadth of information with a high spatial and temporal [...] Read more.
Single-molecule techniques have shifted the paradigm of biological measurements from ensemble measurements to probing individual molecules and propelled a rapid revolution in related fields. Compared to ensemble measurements of biomolecules, single-molecule techniques provide a breadth of information with a high spatial and temporal resolution at the molecular level. Usually, optical and electrical methods are two commonly employed methods for probing single molecules, and some platforms even offer the integration of these two methods such as optofluidics. The recent spark in technological advancement and the tremendous leap in fabrication techniques, microfluidics, and integrated optofluidics are paving the way toward low cost, chip-scale, portable, and point-of-care diagnostic and single-molecule analysis tools. This review provides the fundamentals and overview of commonly employed single-molecule methods including optical methods, electrical methods, force-based methods, combinatorial integrated methods, etc. In most single-molecule experiments, the ability to manipulate and exercise precise control over individual molecules plays a vital role, which sometimes defines the capabilities and limits of the operation. This review discusses different manipulation techniques including sorting and trapping individual particles. An insight into the control of single molecules is provided that mainly discusses the recent development of electrical control over single molecules. Overall, this review is designed to provide the fundamentals and recent advancements in different single-molecule techniques and their applications, with a special focus on the detection, manipulation, and control of single molecules on chip-scale devices. Full article
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