Bacterial Enzymes and Antibiotic Resistance

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 1826

Special Issue Editor

Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, CNRS UMR 9004, CEDEX 5, 34293 Montpellier, France
Interests: mycobacteria; antimicrobial resistance; membrane protein; biochemistry; enzymology; structural biology; aminoglycosides; translation machinery

Special Issue Information

Dear Colleagues,

Antibiotic resistance, defined as the capacity of microorganisms to escape the action of antibiotics, represents a global health problem. It is estimated that 700,000 people die yearly worldwide from drug-resistant bacteria infections, and that this number may reach 50 million by the year 2050. As for human infections, misuse of antibiotics in livestock farming has also triggered antibiotic resistance issues. A huge economic impact is certain if no rapid action is taken over the coming years to overcome antibiotic resistance. Tackling bacterial antibiotic resistance has consequently been classified as a high priority by the World Health Organization. 

Several human pathogens, notably members of the ESKAPE group encompassing Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp., as well as Mycobacterium tuberculosis or non-tuberculous mycobacteria, are notorious examples of bacteria of particular concern regarding antibiotic resistance.  

Mechanisms of drug resistance are highly diverse and can concern one or several antibiotic classes; among these strategies are modification of the cell wall to increase impermeability to drug-like compounds, inactivation of the drug, modification of the drug target, or efflux of the antibiotic.

This Special Issue will publish original research papers or reviews on all aspects of bacterial enzymes involved in antibiotic resistance as well as studies reporting ways to overcome their action.

Dr. Mickael Blaise
Guest Editor

Manuscript Submission Information

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Keywords

  • antibiotic resistance
  • bacteria
  • enzymes
  • efflux pump

Published Papers (1 paper)

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8 pages, 918 KiB  
Case Report
Unraveling the Diversity of Co-Colonization by CPE
by Gabrielle Levi, Mor Lurie-Weinberger, Alona Keren-Paz, Antoine O. Andremont, David Schwartz and Yehuda Carmeli
Microorganisms 2022, 10(7), 1292; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10071292 - 25 Jun 2022
Viewed by 1310
Abstract
Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. [...] Read more.
Antibiotic-resistant bacteria, and more specifically, carbapenem-producing Enterobacterales (CPE) strains, are increasing worldwide. Despite their growing prevalence, in most high-income countries, the detection of CPE is still considered a low-frequency event. Sporadically, patients co-colonized with distinct CPE strains and/or different carbapenemase enzymes are detected. In this paper, we present three cases that illustrate the underlying mechanisms of co-colonization, focusing on horizontal gene transfer (HGT) and patient-to-patient transmission. We also demonstrate the diversity of CPE species and discuss the potential consequences of co-colonization. Full article
(This article belongs to the Special Issue Bacterial Enzymes and Antibiotic Resistance)
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