Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.4
4.5
Journals
Microorganisms
Special Issues
Nutritional Regulation on Gut Microbiota
share announcement

Nutritional Regulation on Gut Microbiota

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: closed (30 October 2021) | Viewed by 27601

Special Issue Editor

Dr. Garry X. Shen

E-Mail Website
Guest Editor
Departments of Internal Medicine, Food and Human Nutritional Science, University of Manitoba, 835-715 McDermot Ave, Winnipeg, MB R3E 3P4, Canada
Interests: diabetes; nutrition; gut microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gut microbiome is a key homeostasis component for maintaining normal health and its imbalance is implicated in the development of a number of common chronic and inflammatory diseases. Foods are the most important regulators for gut microbiome. This Special Issue includes up-to-date research related to the impact of foods, nutrient supplementation, and dietary therapy on gut microbiota in animal models, healthy subjects, or patients with chronic or inflammatory diseases from around the world. Research outcomes will help readers to understand the roles of nutritional intake on regulation of gut microbiota and health of hosts, and encourage the use of nutritional prebiotic foods to prevent and manage relevant health disorders.

Dr. Garry X. Shen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Foods
  • nutrients
  • gut micorbiome
  • prebiotics
  • animals
  • humans
  • diabetes
  • obesity
  • inflammation
  • digesition
  • metabolism
  • short chain fatty acids
  • glucose metabolism

Related Special Issue

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Editorial

Jump to: Research

2 pages, 185 KiB  
Editorial
Special Issue “Nutritional Regulation on Gut Microbiota”: Editorial
by Garry X. Shen
Microorganisms 2023, 11(2), 530; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms11020530 - 19 Feb 2023
Viewed by 976
Abstract
Accumulated lines of evidence demonstrate that the gut microbiota plays a critical role in metabolism, inflammation and the pathophysiology of many chronic diseases [...] Full article
(This article belongs to the Special Issue Nutritional Regulation on Gut Microbiota)

Research

Jump to: Editorial

14 pages, 1664 KiB  
Article
Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults
by Lucía A. Méndez-García, Nallely Bueno-Hernández, Miguel A. Cid-Soto, Karen L. De León, Viridiana M. Mendoza-Martínez, Aranza J. Espinosa-Flores, Miguel Carrero-Aguirre, Marcela Esquivel-Velázquez, Mireya León-Hernández, Rebeca Viurcos-Sanabria, Alejandra Ruíz-Barranco, Julián M. Cota-Arce, Angélica Álvarez-Lee, Marco A. De León-Nava, Guillermo Meléndez and Galileo Escobedo
Microorganisms 2022, 10(2), 434; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10020434 - 14 Feb 2022
Cited by 15 | Viewed by 13965
Abstract
Sucralose consumption alters microbiome and carbohydrate metabolism in mouse models. However, there are no conclusive studies in humans. Our goals were to examine the effect of sucralose consumption on the intestinal abundance of bacterial species belonging to Actinobacteria, Bacteroidetes, and Firmicutes and explore [...] Read more.
Sucralose consumption alters microbiome and carbohydrate metabolism in mouse models. However, there are no conclusive studies in humans. Our goals were to examine the effect of sucralose consumption on the intestinal abundance of bacterial species belonging to Actinobacteria, Bacteroidetes, and Firmicutes and explore potential associations between microbiome profiles and glucose and insulin blood levels in healthy young adults. In this open-label clinical trial, volunteers randomly drank water, as a control (n = 20), or 48 mg sucralose (n = 20), every day for ten weeks. At the beginning and the end of the study, participants were subjected to an oral glucose tolerance test (OGTT) to measure serum glucose and insulin every 15 min for 3 h and provided fecal samples to assess gut microbiota using a quantitative polymerase chain reaction. Sucralose intake altered the abundance of Firmicutes without affecting Actinobacteria or Bacteroidetes. Two-way ANOVA revealed that volunteers drinking sucralose for ten weeks showed a 3-fold increase in Blautia coccoides and a 0.66-fold decrease in Lactobacillus acidophilus compared to the controls. Sucralose consumption increased serum insulin and the area under the glucose curve compared to water. Long-term sucralose ingestion induces gut dysbiosis associated with altered insulin and glucose levels during an OGTT. Full article
(This article belongs to the Special Issue Nutritional Regulation on Gut Microbiota)
►▼ Show Figures

Figure 1

17 pages, 2054 KiB  
Article
Consistent Prebiotic Effects of Carrot RG-I on the Gut Microbiota of Four Human Adult Donors in the SHIME® Model despite Baseline Individual Variability
by Pieter Van den Abbeele, Cindy Duysburgh, Ilse Cleenwerck, Ruud Albers, Massimo Marzorati and Annick Mercenier
Microorganisms 2021, 9(10), 2142; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9102142 - 13 Oct 2021
Cited by 14 | Viewed by 2990
Abstract
The human gut microbiome is currently recognized to play a vital role in human biology and development, with diet as a major modulator. Therefore, novel indigestible polysaccharides that confer a health benefit upon their fermentation by the microbiome are under investigation. Based on [...] Read more.
The human gut microbiome is currently recognized to play a vital role in human biology and development, with diet as a major modulator. Therefore, novel indigestible polysaccharides that confer a health benefit upon their fermentation by the microbiome are under investigation. Based on the recently demonstrated prebiotic potential of a carrot-derived pectin extract enriched for rhamnogalacturonan I (cRG-I), the current study aimed to assess the impact of cRG-I upon repeated administration using the M-SHIME technology (3 weeks at 3g cRG-I/d). Consistent effects across four simulated adult donors included enhanced levels of acetate (+21.1 mM), propionate (+17.6 mM), and to a lesser extent butyrate (+4.1 mM), coinciding with a marked increase of OTUs related to Bacteroides dorei and Prevotella species with versatile enzymatic potential likely allowing them to serve as primary degraders of cRG-I. These Bacteroidetes members are able to produce succinate, explaining the consistent increase of an OTU related to the succinate-converting Phascolarctobacterium faecium (+0.47 log10(cells/mL)). While the Bifidobacteriaceae family remained unaffected, a specific OTU related to Bifidobacterium longum increased significantly upon cRG-I treatment (+1.32 log10(cells/mL)). Additional monoculture experiments suggested that Bifidobacterium species are unable to ferment cRG-I structures as such and that B. longum probably feeds on arabinan and galactan side chains of cRG-I, released by aforementioned Bacteroidetes members. Overall, this study confirms the prebiotic potential of cRG-I and additionally highlights the marked consistency of the microbial changes observed across simulated subjects, suggesting the involvement of a specialized consortium in cRG-I fermentation by the human gut microbiome. Full article
(This article belongs to the Special Issue Nutritional Regulation on Gut Microbiota)
►▼ Show Figures

Figure 1

14 pages, 1726 KiB  
Article
A Pectin-Rich, Baobab Fruit Pulp Powder Exerts Prebiotic Potential on the Human Gut Microbiome In Vitro
by Martin Foltz, Alicia Christin Zahradnik, Pieter Van den Abbeele, Jonas Ghyselinck and Massimo Marzorati
Microorganisms 2021, 9(9), 1981; https://doi.org/10.3390/microorganisms9091981 - 17 Sep 2021
Cited by 10 | Viewed by 4119
Abstract
Increasing insight into the impact of the gut microbiota on human health has sustained the development of novel prebiotic ingredients. This exploratory study evaluated the prebiotic potential of baobab fruit pulp powder, which consists of pectic polysaccharides with unique composition as compared to [...] Read more.
Increasing insight into the impact of the gut microbiota on human health has sustained the development of novel prebiotic ingredients. This exploratory study evaluated the prebiotic potential of baobab fruit pulp powder, which consists of pectic polysaccharides with unique composition as compared to other dietary sources, given that it is rich in low methoxylated homogalacturonan (HG). After applying dialysis procedures to remove simple sugars from the product (simulating their absorption along the upper gastrointestinal tract), 48 h fecal batch incubations were performed. Baobab fruit pulp powder boosted colonic acidification across three simulated human adult donors due to the significant stimulation of health-related metabolites acetate (+18.4 mM at 48 h), propionate (+5.5 mM at 48 h), and to a lesser extent butyrate (0.9 mM at 48 h). Further, there was a trend of increased lactate levels (+2.7 mM at 6h) and reduced branched chain fatty acid (bCFA) levels (−0.4 mM at 48 h). While Bacteroidetes levels increased for all donors, donor-dependent increases in Bifidobacteria, Lactobacilli, and Firmicutes were observed, stressing the potential interindividual differences in microbial composition modulation upon Baobab fruit pulp powder treatment. Overall, Baobab fruit pulp powder fermentation displayed features of selective utilization by host microorganisms and, thus, has promising prebiotic potential (also in comparison with the ‘gold standard’ prebiotic inulin). Further research will be required to better characterize this prebiotic potential, accounting for the interindividual differences, while aiming to unravel the potential resulting health benefits. Full article
(This article belongs to the Special Issue Nutritional Regulation on Gut Microbiota)
►▼ Show Figures

Figure 1

14 pages, 2965 KiB  
Article
Dose-Responses Relationship in Glucose Lowering and Gut Dysbiosis to Saskatoon Berry Powder Supplementation in High Fat-High Sucrose Diet-Induced Insulin Resistant Mice
by Ruozhi Zhao, Fei Huang and Garry X. Shen
Microorganisms 2021, 9(8), 1553; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9081553 - 21 Jul 2021
Cited by 9 | Viewed by 1940
Abstract
Administration of freeze-dried powder of Saskatoon berry (SB), a popular fruit enriched with antioxidants, reduced glucose level, inflammatory markers and gut microbiota disorder in high fat-high sucrose (HFHS) diet-induced insulin resistant mice. The present study examined the dose-response relationship in metabolic, inflammatory and [...] Read more.
Administration of freeze-dried powder of Saskatoon berry (SB), a popular fruit enriched with antioxidants, reduced glucose level, inflammatory markers and gut microbiota disorder in high fat-high sucrose (HFHS) diet-induced insulin resistant mice. The present study examined the dose-response relationship in metabolic, inflammatory and gut microbiotic variables to SB power (SBp) supplementation in HFHS diet-fed mice. Male C57 BL/6J mice were fed with HFHS diet supplemented with 0, 1%, 2.5% or 5% SBp for 11 weeks. HFHS diet significantly increased the levels of fast plasma glucose (FPG), cholesterol, triglycerides, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), tumor necrosis factor-α, monocyte chemotactic protein-1 and plasminogen activator inhibitor-1, but decreased fecal Bacteroidetes phylum bacteria and Muribaculaceae family bacteria compared to low fat diet. SBp dose-dependently reduced metabolic and inflammatory variables and gut dysbiosis in mice compared with mice receiving HFHS diet alone. Significant attenuation of HFHS diet-induced biochemical disorders were detected in mice receiving ≥1% SBp. The abundances of Muribaculaceae family bacteria negatively correlated with body weights, FPG, lipids, insulin, HOMA-IR and inflammatory markers in the mice. The results suggest that SBp supplementation dose-dependently attenuated HFHS diet-induced metabolic and inflammatory disorders, which was associated with the amelioration of gut dysbiosis in the mice. Full article
(This article belongs to the Special Issue Nutritional Regulation on Gut Microbiota)
►▼ Show Figures

Figure 1

18 pages, 4290 KiB  
Article
Changes in the Microbial Composition of the Cecum and Histomorphometric Analysis of Its Epithelium in Broilers Fed with Feed Mixture Containing Fermented Rapeseed Meal
by Ida Szmigiel, Damian Konkol, Mariusz Korczyński, Marcin Łukaszewicz and Anna Krasowska
Microorganisms 2021, 9(2), 360; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms9020360 - 12 Feb 2021
Cited by 11 | Viewed by 2675
Abstract
This study examined the influence of fermented rapeseed meal (FRSM) on the intestinal morphology and gut microflora of broiler chickens. Limited information is available on the effects of FRSM on the intestinal morphology and the gastrointestinal microbiome population of animals. First, 48 21-day [...] Read more.
This study examined the influence of fermented rapeseed meal (FRSM) on the intestinal morphology and gut microflora of broiler chickens. Limited information is available on the effects of FRSM on the intestinal morphology and the gastrointestinal microbiome population of animals. First, 48 21-day Ross 308 broilers were placed in metabolic cages and randomly assigned to four experimental groups. Group I birds were negative controls and received no additive. Group II birds were positive controls and received a 3% addition of unfermented rapeseed meal. Group III birds received a 3% addition of rapeseed meal fermented with the Bacillus subtilis 67 bacterial strain. Group IV birds received a 3% addition of rapeseed meal fermented with the B. subtilis 87Y strain. After 23 days of experimental feeding, the contents of the birds’ ceca were collected for microorganism determination. The histomorphology of the broilers’ ceca was also determined, and beneficial changes were found in the histology of the broilers’ ceca with the additives. Moreover, these materials inhibited the growth of pathogens and significantly stimulated the growth of probiotic bacteria. These results suggest that the addition of 3% FRSM has a potential probiotic effect and can be used as a material in feed for broilers. Full article
(This article belongs to the Special Issue Nutritional Regulation on Gut Microbiota)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop