How Does Pseudomonas aeruginosa Adapt to Its Environment?

A special issue of Microorganisms (ISSN 2076-2607).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3187

Special Issue Editors

Laboratoire Polymères, Biopolymères, Surfaces (PBS), UMR 6270 CNRS, Université de Rouen, 76821 Mont-Saint-Aignan cedex, France
Interests: Biofilms; proteomic; antimicrobials; antimicrobial surfaces
Laboratoire Polymères, Biopolymères, Surfaces (PBS), UMR 6270 CNRS, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France
Interests: post-translational modifications; bacteria; proteomics; mass spectrometry; lysine acylation
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Special Issue Information

Dear Colleagues,

This Special Issue of the journal Microorganisms aims to describe the diversity of mechanisms by which the bacterium Pseudomonas aeruginosa promotes its survival and persistence in various environments. To this end, we will examine the importance and complexity of the regulatory networks by which this bacterial species adjusts its physiological processes to adapt and survive in response to environmental cues and stresses.

Dr. Thierry Jouenne
Dr. Julie Hardouin
Guest Editors

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Keywords

  • P. aeruginosa
  • cystic fibrosis
  • adaptation
  • quorum sensing
  • biofilm
  • resistance
  • persistence

Published Papers (1 paper)

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Review

30 pages, 1985 KiB  
Review
Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Pseudomonas aeruginosa Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance
by Kayla A. Simanek and Jon E. Paczkowski
Microorganisms 2022, 10(6), 1247; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10061247 - 18 Jun 2022
Cited by 12 | Viewed by 2817
Abstract
Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors. QS relies on the group-wide detection of extracellular signal molecules called autoinducers (AI). Quorum sensing is required for virulence and biofilm formation in the human pathogen Pseudomonas aeruginosa. [...] Read more.
Bacteria use a cell-cell communication process called quorum sensing (QS) to orchestrate collective behaviors. QS relies on the group-wide detection of extracellular signal molecules called autoinducers (AI). Quorum sensing is required for virulence and biofilm formation in the human pathogen Pseudomonas aeruginosa. In P. aeruginosa, LasR and RhlR are homologous LuxR-type soluble transcription factor receptors that bind their cognate AIs and activate the expression of genes encoding functions required for virulence and biofilm formation. While some bacterial signal transduction pathways follow a linear circuit, as phosphoryl groups are passed from one carrier protein to another ultimately resulting in up- or down-regulation of target genes, the QS system in P. aeruginosa is a dense network of receptors and regulators with interconnecting regulatory systems and outputs. Once activated, it is not understood how LasR and RhlR establish their signaling hierarchy, nor is it clear how these pathway connections are regulated, resulting in chronic infection. Here, we reviewed the mechanisms of QS progression as it relates to bacterial pathogenesis and antimicrobial resistance and tolerance. Full article
(This article belongs to the Special Issue How Does Pseudomonas aeruginosa Adapt to Its Environment?)
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