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Journals
Microorganisms
Special Issues
Human Oral Microbiome in Health and Disease
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Human Oral Microbiome in Health and Disease

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 3197

Special Issue Editor

Dr. Nir Sterer

E-Mail Website
Guest Editor
Department of Prosthodontics, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
Interests: oral microbiome; oral biofilm; antimicrobial agents; adhesion

Special Issue Information

Dear Colleagues,

The development of next-generation sequencing over the last decade has opened up an exciting new field of research that commands a broad view of the complex and vast microbial population of the oral cavity. Not limited by preconceptions, the microbiome and meta-transcriptome fields have allowed researchers to study oral biofilms under various conditions of health and disease, shedding new light on the interesting topic of pathogenicity and revisiting old dogmas.

This Special Issue of Microorganisms invites researchers to contribute research articles, reviews, and opinions addressing the latest knowledge on the different aspects of the oral microbiome associated with the various conditions affecting the oral cavity such as periodontal disease, dental caries, dental infections, candidiasis, and oral malodor both in health and disease.

Dr. Nir Sterer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oral
  • Microbiome
  • Meta-transcriptome
  • Biofilms
  • NGS

Published Papers (1 paper)

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Research

12 pages, 1665 KiB  
Article
Tooth-Specific Streptococcus mutans Distribution and Associated Microbiome
by Márcia Dinis, William Traynor, Melissa Agnello, Myung-Shin Sim, Xuesong He, Wenyuan Shi, Renate Lux and Nini Chaichanasakul Tran
Microorganisms 2022, 10(6), 1129; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10061129 - 31 May 2022
Cited by 3 | Viewed by 2794
Abstract
Dental caries is multifactorial and polymicrobial in nature and remains one of the most common oral diseases. While caries research has focused on Streptococcus mutans as the main etiological pathogen, its impact at the tooth level is not fully understood. In this cross-sectional [...] Read more.
Dental caries is multifactorial and polymicrobial in nature and remains one of the most common oral diseases. While caries research has focused on Streptococcus mutans as the main etiological pathogen, its impact at the tooth level is not fully understood. In this cross-sectional study, the levels and distribution of S. mutans in the posterior teeth at different dentition stages were investigated along with the corresponding tooth-specific microbiome. Occlusal plaque samples of 87 individual posterior teeth were collected from thirty children in three dentition stages (primary, mixed, and permanent). The S. mutans levels in the occlusal plaque of individual posterior teeth were quantified with qPCR, and those with preferential colonization were selected for tooth-specific microbiome analysis using 16S rRNA sequencing. Results: Quantification of S. mutans levels in the occlusal plaque confirmed the preferential colonization on the first primary and permanent molars. These teeth were selected for further tooth-specific microbiome sequencing, as they also displayed high caries experience. There were significant differences in the relative abundance of the four most abundant genera: Neisseria, Streptococcus, Rothia, and Veillonella. Furthermore, the tooth-level caries experience was correlated with a reduction in the microbiome diversity. Analyzing the different tooth-associated microbial communities, distinct tooth-specific core microbiomes were identified. Conclusions: Our findings suggest that caries susceptibility at the tooth level, depending on tooth type and dentition stage, is influenced by individual species as well as plaque community. Full article
(This article belongs to the Special Issue Human Oral Microbiome in Health and Disease)
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