Marine Vibrios: Antibiotic Resistance and Application

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Environmental Microbiology".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4035

Special Issue Editors


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Guest Editor
Department of Coastal Sciences, The University of Southern Mississippi, Ocean Springs, MS 39564, USA
Interests: VBNC (viable but nonculturable bacteria); vibrio necrotizing fasciitis; antibiotic resistance; plasmid transfer; petroleum degradation; bioremediation
Special Issues, Collections and Topics in MDPI journals
Gulf Coast Research Lab (GCRL), The University of Southern Mississippi, Ocean Springs, MS 39564, USA
Interests: antibiotic resistance; marine microbiology; modelling; molecular diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The genus Vibrio comprises Gram-negative bacteria that are halophilic, mesothermal, and acid-intolerant. They get their name from the fact that they frequently have a short, curved shape. They thrive in estuaries, bays, and coastal waters, and several species of this group are widely distributed in seawater and marine animals. Several vibrios are major pathogens that not only threaten fish and the aquaculture industry but also pose a significant health risk to humans, for example, Vibrio vulnificus. Acute gastroenteritis, sepsis, and necrotizing fascitiis can occur when people eat or come into contact with vibrios, and vibrio disease incidence is on the rise, due to global warming, emissions, and antibiotic misuse. Cephalosporin, tetracycline, fluoroquinolone, or combinations of medications are currently the most popular treatments for vibrio infections. However, several studies have shown that vibrios have developed drug resistance to these current treatment options. As global drug resistance spreads, future marine vibrio bacteria may develop drug resistance to the above antibiotics, posing a greater threat to human health. Until now, drug resistance research has mainly concentrated on medical care or domestic research in different countries, and research collaboration on drug resistance in the seawater environment has not yet been completed. To deal with a potential future crisis of marine vibrio resistance, scientists from various fields around the world must work together to overcome this dilemma.

Prof. Dr. Darrell Jay Grimes
Guest Editor
Dr. Shuo Shen
Co-Guest Editor

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Keywords

  • vibrio disease
  • antibiotic resistance
  • vibrio necrotizing fasciitis
  • marine microbiology

Published Papers (1 paper)

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Review

17 pages, 1107 KiB  
Review
Membrane Efflux Pumps of Pathogenic Vibrio Species: Role in Antimicrobial Resistance and Virulence
by Jerusha Stephen, Manjusha Lekshmi, Parvathi Ammini, Sanath H. Kumar and Manuel F. Varela
Microorganisms 2022, 10(2), 382; https://0-doi-org.brum.beds.ac.uk/10.3390/microorganisms10020382 - 07 Feb 2022
Cited by 12 | Viewed by 3296
Abstract
Infectious diseases caused by bacterial species of the Vibrio genus have had considerable significance upon human health for centuries. V. cholerae is the causative microbial agent of cholera, a severe ailment characterized by profuse watery diarrhea, a condition associated with epidemics, and seven [...] Read more.
Infectious diseases caused by bacterial species of the Vibrio genus have had considerable significance upon human health for centuries. V. cholerae is the causative microbial agent of cholera, a severe ailment characterized by profuse watery diarrhea, a condition associated with epidemics, and seven great historical pandemics. V. parahaemolyticus causes wound infection and watery diarrhea, while V. vulnificus can cause wound infections and septicemia. Species of the Vibrio genus with resistance to multiple antimicrobials have been a significant health concern for several decades. Mechanisms of antimicrobial resistance machinery in Vibrio spp. include biofilm formation, drug inactivation, target protection, antimicrobial permeability reduction, and active antimicrobial efflux. Integral membrane-bound active antimicrobial efflux pump systems include primary and secondary transporters, members of which belong to closely related protein superfamilies. The RND (resistance-nodulation-division) pumps, the MFS (major facilitator superfamily) transporters, and the ABC superfamily of efflux pumps constitute significant drug transporters for investigation. In this review, we explore these antimicrobial transport systems in the context of Vibrio spp. pathogenesis and virulence. Full article
(This article belongs to the Special Issue Marine Vibrios: Antibiotic Resistance and Application)
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