Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.7
4.6
Journals
Molecules
Special Issues
Advance in Carbon Nanostructures as a Delivery System in Nanomedicine
molecules-logo
Submit to Molecules Review for Molecules Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Advance in Carbon Nanostructures as a Delivery System in Nanomedicine

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (11 February 2024) | Viewed by 3163

Special Issue Editor

Dr. Marta Kutwin

E-Mail Website
Guest Editor
Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, Ciszewskiego 8 Str., 02-786 Warsaw, Poland
Interests: nanoparticles; cancer; drug delivery systems; biostatistics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue deals with all aspects of carbon-based delivery systems in nanomedicine and cancer medicine. The effectiveness of molecules, genes, and drug delivery is limited by poor bioavailability, chemical structures, high toxicity, or inability to reach the targeted cell structures. The carbon-based delivery system of molecules can improve efficiency with the limitation of cell toxicity. Carbon nanostructures such as graphene, graphite, nanodiamond can reduce or even eliminate the side-effect of traditional delivery systems, with high efficiency of molecules, drugs, and gene delivery to target cells or tissues. This Special Issue will cover topics related to the fabrication, characterization of carbon-based delivery systems, and their interaction with cells and tissues, as well as the possibility of clinical usage.

It is my pleasure to invite you to contribute original research articles, as well as review articles.

Dr. Marta Kutwin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nanoparticles 
  • Delivery systems 
  • Nanomedicine 
  • Cancer

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

28 pages, 66789 KiB  
Article
MicroRNA Delivery by Graphene-Based Complexes into Glioblastoma Cells
by Marta Kutwin, Malwina Ewa Sosnowska, Barbara Strojny-Cieślak, Slawomir Jaworski, Maciej Trzaskowski, Mateusz Wierzbicki, Andre Chwalibog and Ewa Sawosz
Molecules 2021, 26(19), 5804; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26195804 - 25 Sep 2021
Cited by 7 | Viewed by 2618
Abstract
Glioblastoma (GBM) is the most common primary and aggressive tumour in brain cancer. Novel therapies, despite achievements in chemotherapy, radiation and surgical techniques, are needed to improve the treatment of GBM tumours and extend patients’ survival. Gene delivery therapy mostly uses the viral [...] Read more.
Glioblastoma (GBM) is the most common primary and aggressive tumour in brain cancer. Novel therapies, despite achievements in chemotherapy, radiation and surgical techniques, are needed to improve the treatment of GBM tumours and extend patients’ survival. Gene delivery therapy mostly uses the viral vector, which causes serious adverse events in gene therapy. Graphene-based complexes can reduce the potential side effect of viral carries, with high efficiency of microRNA (miRNA) or antisense miRNA delivery to GBM cells. The objective of this study was to use graphene-based complexes to induce deregulation of miRNA level in GBM cancer cells and to regulate the selected gene expression involved in apoptosis. The complexes were characterised by Fourier transform infrared spectroscopy (FTIR), scanning transmission electron microscopy and zeta potential. The efficiency of miRNA delivery to the cancer cells was analysed by flow cytometry. The effect of the anticancer activity of graphene-based complexes functionalised by the miRNA sequence was analysed using 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxyanilide salt (XTT) assays at the gene expression level. The results partly explain the mechanisms of miRNA deregulation stress, which is affected by graphene-based complexes together with the forced transport of mimic miR-124, miR-137 and antisense miR-21, -221 and -222 as an anticancer supportive therapy. Full article
(This article belongs to the Special Issue Advance in Carbon Nanostructures as a Delivery System in Nanomedicine)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop