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Chromatography: Principle Theoretical Aspects and Practical Applications—in Memory of Prof. Dr. Hab. Edward Soczewiński (1928–2016)

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 7048

Special Issue Editor

Department of Physical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: liquid chromatography with modern detection techniques; sample preparation; analysis of xenobiotics in various biological samples; analysis of ionic compounds in plant extracts; biological activity of plant extracts
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Special Issue Information

Dear Sirs, Friends, Colleagues and Co-Workers,

Professor Edward Soczewiński was born on September 4, 1928, in Lublin. He studied to pursue chemistry at Maria Curie-Skłodowska University (UMCS) in Lublin. In 1952, he was granted a Master of Science degree in chemistry and soon thereafter was offered the post of assistant to the Department of Inorganic Chemistry at the Medical University of Lublin.

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Prof. Dr. hab. Edward Soczewiński in his office. (Photograph from Great-Little Man: Life and Passions of Prof. Edward Soczewiński,by Wróbel and Chomicka, Lublin, Poland, 2007).

Edward Soczewiński’s scientific career was formidable.

On November 1, 1952, he became the Associate Scientific and Didactic Assistant.

On October 3, 1960, he received his doctorate in chemistry (UMCS, Lublin).

The title of his dissertation was ‘Distribution Capacity in Organic Electrolyte Chromatography on Buffered Paper’ under promoter Prof. Dr. hab. Andrzej Waksmundzki.

The day after defending his doctoral thesis, Dr. Soczewiński left for the University of Stockholm (Stockholm, Sweden) to serve as a postdoctoral fellow in the group of Prof. Carl Wachtmeister, a renowned scientist whose work focused on the extraction of organic compounds from herbal matrixes. Sweden provided an excellent opportunity for the young Polish scientist to apply his primarily academic knowledge. Subsequently, he published a series of papers on his research in Sweden and began to formulate future plans for research.

In 1963, Dr. Soczewiński defended his habilitation thesis, which was predominantly based on experimental results he had obtained in Sweden.

On December 17, 1963, he presented the habilitation colloquium.

On May 25, 1964, his habilitation, RF and RM Coefficients in Some Multi-Component Chromatographic Systems, was approved.

On December 1, 1964, he became Docent of the Chair of Chemistry and Department of Inorganic and Analytical Chemistry.

On August 1, 1970, he became Associate Professor.

On May 1, 1978, he became Professor.

He fulfilled a number of functions at the Medical University of Lublin.

From 1964 to 1998, he was the Head of the Chair and Department of Inorganic and Analytical Chemistry with Laboratory of Physical Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin.

From September 1, 1966 to September 30, 1968, he was the Vice Dean of the Faculty of Pharmacy at the Medical Academy of Lublin.

From October 1, 1968 to August 31, 1972, he was the Dean of the Faculty of Pharmacy at the Medical Academy of Lublin.

From 1981 to 1984, he was the Vice-Rector of the Academy of Medical Sciences in Lublin.

In 1998, he became Doctor Honoris Causa of the Medical Academy of Lublin.

Prof. Soczewiński’s greatest contribution to the field of chromatography was the development of the Soczewiński–Wachtmeister and Snyder–Soczewiński equations, which are still very much used today by chromatography theoreticians to model separation phenomena and solve a variety of practical problems in liquid chromatography.

He authored and co-authored more than 333 research papers, primarily published in internationally recognized research journals; three of which were published in one of the most competitive international journals, Nature.

In his career, he supervised over 200 Master of Science theses. He also supervised 17 doctoral dissertations.

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Doctoral defense of 17th doctor of pharmaceutical sciences, Tomasz Tuzimski, with promoter Prof. Dr. hab. Edward Soczewiński (January 2, 2002).

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Promotion of the 17th doctor of pharmaceutical sciences, Tomasz Tuzimski, with promoter Prof. Dr. hab. Edward Soczewiński (2002).

In addition, Prof. Dr. hab. Soczewiński personally oversaw 12 habilitation and 11 professorial proceedings.

Prof. Dr. Edward Soczewiński, an eminent and internationally renowned scientist, passed away on December 12, 2016, at the age of 88 in Lublin, Poland.

After defending my MA thesis on June 29, 1995 at the Chair and Department of Inorganic and Analytical Chemistry with Laboratory of Physical Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, Prof. Edward Soczewiński offered me a position within one of the departments he oversaw. On October 2, 1995, I became a scientific and didactic assistant. From the outset, I admired Prof. Soczewiński. I respected him and looked up to him with admiration and sympathy, not only because he was an outstanding scientist, but above all because he was a great and good man. I appreciated him also for his immense personal culture and sense of humor.

I warmly invite colleagues and great scientists of international scientific repute to submit their original contributions to this Special Issue, especially those who personally knew Professor Edward Soczewiński. This Special Issue of Molecules welcomes manuscripts describing original work as well as review articles.

I would be delighted if you could respond and upload papers by 30 September 2022 (deadline).

 The Guest Editor will be pleased to accept and review manuscripts that address the topics listed below, but papers need not restricted to this list:

  • analytical chemistry
  • physical chemistry
  • separation sciences
  • chromatographic methods and related techniques (HPLC, SPE, SFC, GC, CZE, UPLC, GC × GC, and others)
  • sample preparation and extraction techniques (SPE, QuEChERS/d-SPE, SPME, SBSE, HFLPME, DLLME, FUSLE, and others)
  • detection techniques (DAD, FLD, MS, MS/MS, and others)
  • spectrometry
  • bioanalytics
  • metabolomics
  • nanotechnology
  • environmental sciences
  • natural products chemistry
  • modeling and chemometrics
  • separation of multicomponent mixtures of analytes

Prof. Dr. Tomasz Tuzimski
Guest Editor

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Published Papers (2 papers)

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Research

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26 pages, 3274 KiB  
Article
Isoquinoline Alkaloid Contents in Macleaya cordata Extracts and Their Acetylcholinesterase and Butyrylcholinesterase Inhibition
by Tomasz Tuzimski, Anna Petruczynik, Małgorzata Szultka-Młyńska, Mateusz Sugajski and Bogusław Buszewski
Molecules 2022, 27(11), 3606; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27113606 - 03 Jun 2022
Cited by 5 | Viewed by 1826
Abstract
An important strategy for treating neurodegenerative disorders is to maintain the levels of acetylcholine in the synaptic cleft by blocking the cholinesterases. Searching for new effective compounds with inhibited acetylcholinesterase and butyrylcholinesterase activity is one of the most significant challenges of the modern [...] Read more.
An important strategy for treating neurodegenerative disorders is to maintain the levels of acetylcholine in the synaptic cleft by blocking the cholinesterases. Searching for new effective compounds with inhibited acetylcholinesterase and butyrylcholinesterase activity is one of the most significant challenges of the modern scientific research. The aim of this study was the optimization of the condition for cholinesterase activity determination by high-performance liquid chromatography coupled with diode array detector (HPLC-DAD) in terms of concentrations of enzymatic reaction mixture components, temperature of incubation, and incubation time. In vitro investigation of acetylcholinesterase and butyrylcholinesterase activity inhibition by some isoquinoline alkaloids and extracts obtained from the aerial part and roots of Macleaya cordata collected in May, July, and September. Acetylcholinesterase and butyrylcholinesterase activity inhibition of the extracts obtained from the plant had not been tested previously. The application of the HPLC method allowed eliminating absorption of interfering components, for example, alkaloids such as sanguinarine and berberine. The HPLC method was successfully applied for the evaluation of the acetylcholinesterase inhibitory activity in samples such as plant extracts, especially those containing colored components adsorbing at the same wavelength as the adsorption wavelength of 5-thio-2-nitro-benzoic acid, which is the product of the reaction between thiocholine (product of the hydrolysis of acetyl/butyrylthiocholine reaction) with Ellman’s reagent. Moreover, liquid chromatography coupled with a triple quadrupole mass spectrometer (LC–QqQ–ESI–MS/MS) analysis allowed evaluating the identification of relevant bioactive compounds in the obtained plant extracts. The investigated alkaloids, especially sanguinarine and chelerythrine, and all the Macleaya cordata extracts, especially the extract obtained from the aerial part collected in May, exhibited very high cholinesterase activity inhibition. HPLC-DAD was also applied for the kinetics study of the most active alkaloids sanguinarine and chelerythrine. Our investigations demonstrated that these plant extracts can be recommended for further in vivo experiments to confirm their cholinesterase inhibition activity. Full article
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Review

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48 pages, 4769 KiB  
Review
Determination of Anti-Alzheimer’s Disease Activity of Selected Plant Ingredients
by Tomasz Tuzimski and Anna Petruczynik
Molecules 2022, 27(10), 3222; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27103222 - 18 May 2022
Cited by 23 | Viewed by 4044
Abstract
Neurodegenerative diseases, among which one of the more common is Alzheimer’s disease, are the one of the biggest global public health challenges facing our generation because of the increasing elderly population in most countries. With the growing burden of these diseases, it is [...] Read more.
Neurodegenerative diseases, among which one of the more common is Alzheimer’s disease, are the one of the biggest global public health challenges facing our generation because of the increasing elderly population in most countries. With the growing burden of these diseases, it is essential to discover and develop new treatment options capable of preventing and treating them. Neurodegenerative diseases, among which one of the most common is Alzheimer’s disease, are a multifactorial disease and therefore demand multiple therapeutic approaches. One of the most important therapeutic strategies is controlling the level of acetylcholine—a neurotransmitter in cholinergic synapses—by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. However, these drugs can cause some adverse side effects, such as hepatotoxicity and gastrointestinal disorder. Thus, the search for new, more effective drugs is very important. In the last few years, different active constituents from plants have been tested as potential drugs in neurodegenerative disease therapy. The availability, lower price and less toxic effects of herbal medicines compared with synthetic agents make them a simple and excellent choice in the treatment of neurodegenerative diseases. The empirical approach to discovering new drugs from the systematic screening of plant extracts or plant-derived compounds is still an important strategy when it comes to finding new biologically active substances. The aim of this review is to identify new, safe and effective compounds that are potential candidates for further in vivo and clinical tests from which more effective drugs for the treatment of Alzheimer’s disease could be selected. We reviewed the methods used to determine anti-Alzheimer’s disease activity. Here, we have discussed the relevance of plant-derived compounds with in vitro activity. Various plants and phytochemical compounds have shown different activity that could be beneficial in the treatment of Alzheimer’s disorders. Most often, medicinal plants and their active components have been investigated as acetylcholinesterase and/or butyrylcholinesterase activity inhibitors, modifiers of β-amyloid processing and antioxidant agents. This study also aims to highlight species with assessed efficacy, usable plant parts and the most active plant components in order to identify species and compounds of interest for further study. Future research directions are suggested and recommendations made to expand the use of medicinal plants, their formulations and plant-derived active compounds to prevent, mitigate and treat Alzheimer’s disease. Full article
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