Dear Colleagues,

Viral infectious diseases continue to be a major health concern worldwide, causing relevant epidemiological, financial, and logistical implications, as we are experimenting in these months. The use of many conventional drugs is hampered by a lack of efficacy, the emergence of resistance, adverse effects, and high costs. Thus, new strategies and therapeutic alternatives are constantly needed. Nucleosides are fundamental building blocks of biological systems that show a wide range of biological activities. Consequently, extensive modifications have been made to both the heterocyclic base and the sugar moiety in order to avoid the drawbacks shown by nucleosides or analogues in certain applications, mainly due to enzymatic degradations. The design and synthesis of molecules for the fight against new aggressive and fatal diseases remain important challenges.

This Special Issue in Molecules aims to attract contributions on all the aspects concerning the synthesis through different strategies of classical nucleosides, carbocyclic nucleosides, and analogues. These results can be considered fully consistent if in vitro biological evaluations of the synthetized compounds are also reported. This will be the challenge to further explore the range of biological effects and potential applications as antivirals of brand-new compounds.

Prof. Dr. Paolo Quadrelli
Guest Editor

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• Nucleosides
• Nucleoside analogues
• Synthetic strategy
• Antivirals
• Biological evaluation
• Structure activity relationship