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Biomedical Applications of Nanomaterials 2021
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Biomedical Applications of Nanomaterials 2021

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".

Deadline for manuscript submissions: closed (15 May 2022) | Viewed by 9931

Special Issue Editor

Prof. Dr. Kelong Ai

E-Mail Website
Guest Editor
Xiangya School of Pharmaceutical Sciences, Hunan Provincial Key Laboratory of Cardiovascular Research, Central South University, Changsha 410078, China
Interests: nanoparticles; nanomedicine; cancer; acute kidney injury; inflammation; immunity; reactive oxygen radicals

Special Issue Information

Dear Colleagues,

The sizes of nanomaterials range between those of biomolecules and cells. In theory, the careful design of nanomaterials can realize cell state and function regulation. Therefore, the use of nanomaterials for biomedical applications has received tremendous interest in the past two decades. Advances in nanotechnology have further made it possible to engineer complex nanostructures with unique physical properties and surface chemistry, with many potential merits compared to traditional therapeutic agents. In this Special Issue, we aim to highlight recent advances and developments in nanomaterials and biomedical applications. We invited investigators to submit articles (original research and reviews) that describe the latest techniques in nanomaterial synthesis, characterization, and biomedical applications. Potential topics include, but are not limited to, the following:

Synthesis and characterization of bioactive nanomaterials;

Cancer nanotherapy;

Nanomaterials for bacterial infection;

Nanomaterials for cardiovascular diseases;

Nanomaterials for brain disease;

Nanomaterials for inflammation;

Nanomaterials for immune regulation;

Advances in nanomaterials and biomedical applications.

Prof. Dr. Kelong Ai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • inflammation
  • immune regulation
  • cancer
  • cardiovascular diseases
  • brain disease

Published Papers (3 papers)

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Research

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17 pages, 3675 KiB  
Article
Green Synthesis of Silver Nanoparticles Using Euphorbia wallichii Leaf Extract: Its Antibacterial Action against Citrus Canker Causal Agent and Antioxidant Potential
by Muhammad Arif, Rahim Ullah, Maaz Ahmad, Ahmad Ali, Zahid Ullah, Mohammad Ali, Fakhria A. Al-Joufi, Muhammad Zahoor and Hassan Sher
Molecules 2022, 27(11), 3525; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27113525 - 30 May 2022
Cited by 14 | Viewed by 2800
Abstract
Biologically synthesized silver nanoparticles are emerging as attractive alternatives to chemical pesticides due to the ease of their synthesis, safety and antimicrobial activities in lower possible concentrations. In the present study, we have synthesized silver nanoparticles (AgNPs) using the aqueous extract of the [...] Read more.
Biologically synthesized silver nanoparticles are emerging as attractive alternatives to chemical pesticides due to the ease of their synthesis, safety and antimicrobial activities in lower possible concentrations. In the present study, we have synthesized silver nanoparticles (AgNPs) using the aqueous extract of the medicinal plant Euphorbia wallichii and tested them against the plant pathogenic bacterium Xanthomonas axonopodis, the causative agent of citrus canker, via an in vitro experiment. The synthesized silver nanoparticles were characterized by techniques such as UV-Vis spectroscopy, Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction analysis and transmission electron microscopy. Moreover, the plant species were investigated for phenolics, flavonoids and antioxidant activity. The antioxidant potential of the extract was determined against a DPPH radical. The extract was also evaluated for phenolic compounds using the HPLC technique. The results confirmed the synthesis of centered cubic, spherical-shaped and crystalline nanoparticles by employing standard characterization techniques. A qualitative and quantitative phytochemical analysis revealed the presence of phenolics (41.52 mg GAE/g), flavonoids (14.2 mg QE/g) and other metabolites of medicinal importance. Different concentrations (1000 µg/mL to 15.62 µg/mL—2 fold dilutions) of AgNPs and plant extract (PE) alone, and both in combination (AgNPs-PE), exhibited a differential inhibition of X. axanopodis in a high throughput antibacterial assay. Overall, AgNPs-PE was superior in terms of displaying significant antibacterial activity, followed by AgNPs alone. An appreciable antioxidant potential was recorded as well. The observed antibacterial and antioxidant potential may be attributed to eight phenolic compounds identified in the extract. The Euphorbia wallichii leaf-extract-induced synthesized AgNPs exhibited strong antibacterial activity against X. axanopodis, which could be exploited as effective alternative preparations against citrus canker in planta in a controlled environment. In addition, as a good source of phenolic compounds, the plant could be further exploited for potent antioxidants. Full article
(This article belongs to the Special Issue Biomedical Applications of Nanomaterials 2021)
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Review

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18 pages, 5050 KiB  
Review
Applications of Titanium Dioxide Nanostructure in Stomatology
by Shuang Liu, Xingzhu Chen, Mingyue Yu, Jianing Li, Jinyao Liu, Zunxuan Xie, Fengxiang Gao and Yuyan Liu
Molecules 2022, 27(12), 3881; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules27123881 - 17 Jun 2022
Cited by 13 | Viewed by 3249
Abstract
Breakthroughs in the field of nanotechnology, especially in nanochemistry and nanofabrication technologies, have been attracting much attention, and various nanomaterials have recently been developed for biomedical applications. Among these nanomaterials, nanoscale titanium dioxide (nano-TiO2) has been widely valued in stomatology due [...] Read more.
Breakthroughs in the field of nanotechnology, especially in nanochemistry and nanofabrication technologies, have been attracting much attention, and various nanomaterials have recently been developed for biomedical applications. Among these nanomaterials, nanoscale titanium dioxide (nano-TiO2) has been widely valued in stomatology due to the fact of its excellent biocompatibility, antibacterial activity, and photocatalytic activity as well as its potential use for applications such as dental implant surface modification, tissue engineering and regenerative medicine, drug delivery carrier, dental material additives, and oral tumor diagnosis and treatment. However, the biosafety of nano-TiO2 is controversial and has become a key constraint in the development of nano-TiO2 applications in stomatology. Therefore, in this review, we summarize recent research regarding the applications of nano-TiO2 in stomatology, with an emphasis on its performance characteristics in different fields, and evaluations of the biological security of nano-TiO2 applications. In addition, we discuss the challenges, prospects, and future research directions regarding applications of nano-TiO2 in stomatology that are significant and worthy of further exploration. Full article
(This article belongs to the Special Issue Biomedical Applications of Nanomaterials 2021)
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18 pages, 2799 KiB  
Review
The Application of Chitosan Nanostructures in Stomatology
by Shunli Chu, Jue Wang and Fengxiang Gao
Molecules 2021, 26(20), 6315; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26206315 - 19 Oct 2021
Cited by 2 | Viewed by 3243
Abstract
Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, [...] Read more.
Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, and their biodegradability. Nano-CSs can be applied as drug carriers for soft tissue diseases, bone tissue engineering and dental hard tissue remineralization; furthermore, they have been used in endodontics due to their antibacterial properties; and, finally, nano-CS can improve the adhesion and mechanical properties of dental-restorative materials due to their physical blend and chemical combinations. In this review, recent developments in the application of nano-CS for stomatology are summarized, with an emphasis on nano-CS’s performance characteristics in different application fields. Moreover, the challenges posed by and the future trends in its application are assessed. Full article
(This article belongs to the Special Issue Biomedical Applications of Nanomaterials 2021)
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