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Carbohydrate Chemistry 2021

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3770

Special Issue Editors

Univ Rennes, Ecole Nationale Supérieure de Chimie de, Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France
Interests: carbohydrate chemistry; glycochemistry; biocatalysis; bioactive molecules; innovative approaches
Univ Rennes, Ecole Nationale Supérieure de Chimie de, Rennes, CNRS, ISCR-UMR 6226, F-35000 Rennes, France
Interests: glycochemistry; sustainable glycosidic synthesis; glyco-therapeutics; glycoenzymes

Special Issue Information

Dear Colleagues,

The field of glycochemistry, founded by E. Fischer, has since experienced many evolutions, sometimes even revolutions. Even if the term carbohydrates still seems to frighten some confirmed researchers, as well as many students, no one can deny their importance and in particular their involvement in numerous biological processes. The structural biodiversity of carbohydrates and the variety of glycoforms in glycoconjugates are difficult to grasp, and, consequently, there is also analysis difficult. Anomeric effects and the subtle reactivity differences between the main twenty monosaccharides surprise young generations. Low energy interactions are complex to model and remain a challenge for our community and beyond.

This Special Issue is open to submissions from all colleagues with recent results or review articles looking at carbohydrates and glycoconjugates at the frontiers of biology and physic. Basic research, innovative synthetic strategies for preparing glycoconjugates, new molecular tools for studying carbohydrate metabolism, catabolism, or interactions with macromolecules, applications in the fields of human, animal, and plant health are welcome for publication in this issue.

Prof. Dr. Vincent Ferrières
Dr. Laurent Legentil
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Carbohydrate chemistry of the future
  • Carbohydrates as therapeutic, diagnostic agents
  • Glyco-chemobiology
  • Glycoconjugates
  • Multi-valency

Published Papers (1 paper)

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Research

12 pages, 2286 KiB  
Article
d-Allulose Ameliorates Skeletal Muscle Insulin Resistance in High-Fat Diet-Fed Rats
by Yang Gou, Bingyang Liu, Mengyao Cheng, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno and Teruhiko Koike
Molecules 2021, 26(20), 6310; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26206310 - 19 Oct 2021
Cited by 10 | Viewed by 3012
Abstract
Background: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. Objective: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance [...] Read more.
Background: d-Allulose is a rare sugar with antiobesity and antidiabetic activities. However, its direct effect on insulin sensitivity and the underlying mechanism involved are unknown. Objective: This study aimed to investigate the effect of d-allulose on high-fat diet (HFD)-induced insulin resistance using the hyperinsulinemic–euglycemic (HE)-clamp method and intramuscular signaling analysis. Methods: Wistar rats were randomly divided into three dietary groups: chow diet, HFD with 5% cellulose (HFC), and HFD with 5% d-allulose (HFA). After four weeks of feeding, the insulin tolerance test (ITT), intraperitoneal glucose tolerance test (IPGTT), and HE-clamp study were performed. The levels of plasma leptin, adiponectin, and tumor necrosis factor (TNF)-α were measured using the enzyme-linked immunosorbent assay. We analyzed the levels of cell signaling pathway components in the skeletal muscle using Western blotting. Results: d-allulose alleviated the increase in HFD-induced body weight and visceral fat and reduced the area under the curve as per ITT and IPGTT. d-Allulose increased the glucose infusion rate in the two-step HE-clamp test. Consistently, the insulin-induced phosphorylation of serine 307 in the insulin receptor substrate-1 and Akt and expression of glucose transporter 4 (Glut-4) in the muscle were higher in the HFA group than HFC group. Furthermore, d-allulose decreased plasma TNF-α concentration and insulin-induced phosphorylation of stress-activated protein kinase/Jun N-terminal kinase in the muscle and inhibited adiponectin secretion in HFD-fed rats. Conclusions: d-allulose improved HFD-induced insulin resistance in Wistar rats. The reduction of the proinflammatory cytokine production, amelioration of adiponectin secretion, and increase in insulin signaling and Glut-4 expression in the muscle contributed to this effect. Full article
(This article belongs to the Special Issue Carbohydrate Chemistry 2021)
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