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Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017)

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (15 October 2017) | Viewed by 26839

Special Issue Editors

Dr. Angeles Heras Caballero

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Guest Editor
Associate professor and presently Head of Dept. at Department of Pharmaceutical Physical-Chemistry, Faculty of Pharmacy, University of Madrid (UCM). Infiqus promoter, Spain
Interests: chitin; chitosan; functional characterization; natural products; chitosan applications (food, cosmetic, pharmaceutic, biomedical)
Dr. Francisca Cabrera-Escribano

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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville, Spain
Interests: chitosan; carbohydrate chemistry; fluorescent heteroaromatic systems; sensing biomaterials; glycoaminoacids; organic synthesis; noncovalent interactions; heterogeneous organocatalysis
Dr. Inmaculada Aranaz Corral

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Guest Editor
Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Complutense University of Madrid (UCM), 28040 Madrid, Spain
Interests: polymer chemistry; natural polymers; green processes; metallic nanoparticles; drug delivery; antimicrobial; polimeric matrix; biomaterials; composites
Special Issues, Collections and Topics in MDPI journals
Dr. Florentina Niuris Acosta Contreras

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Guest Editor
Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: biopolymers; chitosan derivatives; physico-chemical and functional characterization; green processes; polymer networks; biomaterials; drug delivery; pharmaceutical formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017)—will be jointly held from 31 May to 3 June, 2017, in Seville, Spain, at the Faculty of Chemistry, located at the Reina Mercedes Science Campus of the University of Seville.

Supported by a strong international advisory board, we have designed the conference as a meeting point for young, junior and senior researchers, producers and developers of chitin/chitosan-based products from all over the word. The program of EUCHIS-SIAQ 2017 Congress aims at fostering communication between our Scientific Societies and between Science and Industry. The conference will offer a wide interdisciplinary exchange at the forefront of chitin/chitosan science with a strong presence of suppliers, manufacturers and end-users companies. A specific session with information on funding opportunities for researchers, companies and research-company consortium will be also held. The conference will be preceded by an Industrial Meeting to face up the Industry challenges that will be held in Madrid, and followed by the second edition of the Young Research Meeting to be held in Seville. Excellent speakers will present their results within individual sections of EUCHIS-SIAQ 2017. For all details please see http://www.chitin2017.com, where the full list of presenters is available, including Caroline Hoemann, Laurent David, Alessandro Gandini, Hermenegildo García, and many others.

Participants of the Conference are cordially invited to contribute original research papers or reviews to this Special Issue of Molecules.

Assoc. Prof. Dr Angeles Heras Caballero (A. Heras)
Assoc. Prof. Dr. Francisca Cabrera-Escribano (F. Cabrera-Escribano)
Ph.D. Inmaculada Aranaz Corral (I. Aranaz)
Ph.D. Florentina Niuris Acosta Contreras (N. Acosta)
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (5 papers)

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Research

11241 KiB  
Article
Design of New-Generation Usable Forms of Topical Haemostatic Agents Containing Chitosan
by Dorota Zielińska, Marcin H. Struszczyk, Longina Madej-Kiełbik, Edyta Chmal-Fudali, Magdalena Kucharska, Maria Wiśniewska-Wrona and Kinga Brzoza-Malczewska
Molecules 2017, 22(12), 2240; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22122240 - 15 Dec 2017
Cited by 10 | Viewed by 4044
Abstract
Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development [...] Read more.
Designing usable forms of topical haemostatic agents is the most important activity during the design process, resulting in strengthened functional properties of the final medical devices. This study aimed to propose indications for a research programme based on risk management supporting the development of two usable forms of a topical haemostatic agent: chitosan/alginate lyophilized foam and chitosan/alginate impregnated gauze. Both of the usable forms of the topical haemostatic agent, being the main part of the modified combat gauze, were fabricated using the chitosan/alginate complex. Risk analysis is helpful in developing an appropriate research programme, significantly reducing the risk to an acceptable level. Full article
(This article belongs to the Special Issue Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017))
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2314 KiB  
Article
Two-Ply Composite Membranes with Separation Layers from Chitosan and Sulfoethylcellulose on a Microporous Support Based on Poly(diphenylsulfone-N-phenylphthalimide)
by Svetlana V. Kononova, Elena V. Kruchinina, Valentina A. Petrova, Yulia G. Baklagina, Kira A. Romashkova, Anton S. Orekhov, Vera V. Klechkovskaya and Yury A. Skorik
Molecules 2017, 22(12), 2227; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22122227 - 14 Dec 2017
Cited by 7 | Viewed by 3540
Abstract
Two-ply composite membranes with separation layers from chitosan and sulfoethylcellulose were developed on a microporous support based on poly(diphenylsulfone-N-phenylphthalimide) and investigated by use of X-ray diffraction and scanning electron microscopy methods. The pervaporation properties of the membranes were studied for the [...] Read more.
Two-ply composite membranes with separation layers from chitosan and sulfoethylcellulose were developed on a microporous support based on poly(diphenylsulfone-N-phenylphthalimide) and investigated by use of X-ray diffraction and scanning electron microscopy methods. The pervaporation properties of the membranes were studied for the separation of aqueous alcohol (ethanol, propan-2-ol) mixtures of different compositions. When the mixtures to be separated consist of less than 15 wt % water in propan-2-ol, the membranes composed of polyelectrolytes with the same molar fraction of ionogenic groups (-NH3+ for chitosan and -SO3− for sulfoethylcellulose) show high permselectivity (the water content in the permeate was 100%). Factors affecting the structure of a non-porous layer of the polyelectrolyte complex formed on the substrate surface and the contribution of that complex to changes in the transport properties of membranes are discussed. The results indicate significant prospects for the use of chitosan and sulfoethylcellulose for the formation of highly selective pervaporation membranes. Full article
(This article belongs to the Special Issue Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017))
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2977 KiB  
Article
Chitosan Spray-Dried Microparticles for Controlled Delivery of Venlafaxine Hydrochloride
by Inmaculada Aranaz, Ines Paños, Carlos Peniche, Ángeles Heras and Niuris Acosta
Molecules 2017, 22(11), 1980; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22111980 - 15 Nov 2017
Cited by 42 | Viewed by 5139
Abstract
Venlafaxine controlled drug delivery systems using different matrixes have been tested to reduce undesirable side effects in the treatment of depression. The legal status of chitosan (Cs) in Pharmacy has dramatically improved after its acceptance as excipient in several Pharmacopeias and, therefore, there [...] Read more.
Venlafaxine controlled drug delivery systems using different matrixes have been tested to reduce undesirable side effects in the treatment of depression. The legal status of chitosan (Cs) in Pharmacy has dramatically improved after its acceptance as excipient in several Pharmacopeias and, therefore, there is great interest in pharmaceutical formulations based on this polymer. In this paper, chitosan microcapsules cross-linked with sodium tripolyphosphate (TPP) for oral delivery of venlafaxine were formulated using the spray drying technique. The effect of chitosan physico-chemical properties, TPP concentration and TPP/Cs ratio on drug release was evaluated. The microcapsules were characterized in terms of size, zeta potential and morphology. The physical state of the drug was determined by X-ray diffraction (XRD) and the drug release from the microcapsules was studied in simulated gastric and intestinal fluids. The release pattern fitted well to the Peppas-Koersmeyer model with n exponents indicating anomalous transport. Full article
(This article belongs to the Special Issue Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017))
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4671 KiB  
Article
Chitosan/Cyclodextrin/TPP Nanoparticles Loaded with Quercetin as Novel Bacterial Quorum Sensing Inhibitors
by Hao Thanh Nguyen and Francisco M. Goycoolea
Molecules 2017, 22(11), 1975; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22111975 - 15 Nov 2017
Cited by 36 | Viewed by 6380
Abstract
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate [...] Read more.
The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Captisol®) and/or pentasodium tripolyphosphate using ionotropic gelation technique, and to evaluate their potential capacity to arrest QS in bacteria. The resulting NPs were in the size range of 250–400 nm with CS70/5 and 330–600 nm with CS70/20, had low polydispersity index (<0.25) and highly positive zeta potential ranging from ζ ~+31 to +40 mV. Quercetin, a hydrophobic model flavonoid, could be incorporated proportionally with increasing amounts of Captisol® in the NPs formualtion, without altering significantly its physicochemical properties. Elemental analysis and FTIR studies revealed that Captisol® and quercetin were effectively integrated into the NPs. These NPs were stable in M9 bacterial medium for 7 h at 37 °C. Further, NPs containing Captisol® seem to prolong the release of associated drug. Bioassays against an E. coli Top 10 QS biosensor revealed that CS70/5 NPs could inhibit QS up to 61.12%, while CS70/20 NPs exhibited high antibacterial effects up to 88.32%. These results suggested that the interaction between NPs and the bacterial membrane could enhance either anti-QS or anti-bacterial activities. Full article
(This article belongs to the Special Issue Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017))
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2723 KiB  
Article
Electrostatic Self-Assembled Chitosan-Pectin Nano- and Microparticles for Insulin Delivery
by Vinicius B. V. Maciel, Cristiana M. P. Yoshida, Susana M. S. S. Pereira, Francisco M. Goycoolea and Telma T. Franco
Molecules 2017, 22(10), 1707; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22101707 - 12 Oct 2017
Cited by 85 | Viewed by 6964
Abstract
A polyelectrolyte complex system of chitosan-pectin nano- and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to obtain small particles for oral insulin delivery without chemical crosslinkers based on natural and biodegradable polysaccharides. The nano- and microparticles [...] Read more.
A polyelectrolyte complex system of chitosan-pectin nano- and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to obtain small particles for oral insulin delivery without chemical crosslinkers based on natural and biodegradable polysaccharides. The nano- and microparticles were developed using chitosans (with different degrees of acetylation: 15.0% and 28.8%) and pectin solutions at various charge ratios (n+/n− given by the chitosan/pectin mass ratio) and total charge. Nano- and microparticles were characterized regarding particle size, zeta potential, production yield, encapsulation efficiency, stability in different media, transmission electron microscopy and cytotoxicity assays using Caco-2 cells. The insulin release was evaluated in vitro in simulated gastric and intestinal media. Small-sized particles (~240–~1900 nm) with a maximum production yield of ~34.0% were obtained. The highest encapsulation efficiency (~62.0%) of the system was observed at a charge ratio (n+/n−) 5.00. The system was stable in various media, particularly in simulated gastric fluid (pH 1.2). Transmission electron microscopy (TEM) analysis showed spherical shape particles when insulin was added to the system. In simulated intestinal fluid (pH 6.8), controlled insulin release occurred over 2 h. In vitro tests indicated that the proposed system presents potential as a drug delivery for oral administration of bioactive peptides. Full article
(This article belongs to the Special Issue Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017))
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