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Metallodrugs, Metallopharmaceuticals and Bio-Inspired Metal-organic Frameworks

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 6659

Special Issue Editor


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Guest Editor
1. Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal
2. Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento (IST-ID), Av. Rovisco Pais 1, 1049-003 Lisbon, Portugal
Interests: mechanochemistry; crystal engineering; supramolecular chemistry; BioMOFs; polymorphs; co-crystals; metallodrugs and metallopharmaceuticals; Antibiotic Coordination Frameworks (ACFs)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metallodrugs, metallopharmaceuticals, and bio-inspired metal–organic frameworks (BioMOFs) can play an important role in the quest for more efficient and cost-effective therapeutics, a very demanding issue within the pharmaceutical industry.

Even though the use of metal-containing compounds for pharmaceutical applications is long-known, these forms are much less explored than organic molecules. Metallodrugs and metallopharmaceuticals have been reported as effective systems to battle several diseases, such as cancer and infectious illnesses. BioMOFs are groundbreaking materials that have recently been explored for drug storage, delivery, and controlled release, as well as for applications in imaging and sensing for therapeutics and diagnostics. BioMOFs can further be used to enhance the properties of currently available forms.

Traditionally, the synthesis of such compounds is based on solution techniques. However, sustainable procedures, such as mechanochemistry and microwave-assisted synthesis, have been presented as promising and advantageous alternatives.

The aim of this Special Issue is to report the most recent developments in metallodrugs, metallopharmaceuticals, and BioMOFs, and to show how they can contribute to the pharmaceutical industry. The use of sustainable synthetic techniques is encouraged.

Dr. Vânia André
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Metallopharmaceuticals
  • Metallodrugs
  • Bio-inspired metal–organic frameworks
  • Drug properties
  • Sustainable synthesis

Published Papers (2 papers)

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Research

19 pages, 8317 KiB  
Article
Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry
by Sílvia Quaresma, Paula C. Alves, Patrícia Rijo, M. Teresa Duarte and Vânia André
Molecules 2021, 26(7), 1904; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26071904 - 28 Mar 2021
Cited by 10 | Viewed by 2808
Abstract
The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. [...] Read more.
The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds unravelling improved antimycobacterial activity. Mechanochemistry was the preferred synthetic technique to yield novel compounds, allowing the reproduction of a 1D zinc framework, the synthesis of a novel hydrogen bonding manganese framework, and three new compounds with silver. The structural characterization of the novel forms is presented along with stability studies. The increased antimicrobial activity of the new silver-based frameworks against Escherichia coli, Staphylococcus aureus, and Mycobacterium smegmatis is particularly relevant. Full article
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18 pages, 5294 KiB  
Article
Methotrexate Gold Nanocarriers: Loading and Release Study: Its Activity in Colon and Lung Cancer Cells
by Beatriz Álvarez-González, Marisa Rozalen, María Fernández-Perales, Miguel A. Álvarez and Manuel Sánchez-Polo
Molecules 2020, 25(24), 6049; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules25246049 - 21 Dec 2020
Cited by 18 | Viewed by 3105
Abstract
In the present study, the synthesis of gold nanoparticles (AuNPs) loaded with methotrexate (MTX) has been carried out in order to obtain controlled size and monodispersed nanocarriers of around 20 nm. The characterization study shows metallic AuNPs with MTX polydispersed on the surface. [...] Read more.
In the present study, the synthesis of gold nanoparticles (AuNPs) loaded with methotrexate (MTX) has been carried out in order to obtain controlled size and monodispersed nanocarriers of around 20 nm. The characterization study shows metallic AuNPs with MTX polydispersed on the surface. MTX is linked by the replacement of citrate by the MTX carboxyl group. The drug release profiles show faster MTX release when it is conjugated, which leads to the best control of plasma concentration. Moreover, the enhanced release observed at pH 5 could take advantage of the pH gradients that exist in tumor microenvironments to achieve high local drug concentrations. AuNP–MTX conjugates were tested by flow cytometry against lung (A-549) and colon (HTC-116) cancer cell lines. Results for A-549 showed a weaker dose–response effect than for colon cancer ones. This could be related to the presence of folate receptors in line HTC-116 in comparison to line A-549, supporting the specific uptake of folate-conjugated AuNP–MTX by folate receptor positive tumor cells. Conjugates exhibited considerably higher cytotoxic effects compared with the effects of equal doses of free MTX. Annexin V-PI tests sustained the cell death mechanism of apoptosis, which is normally disabled in cancer cells. Full article
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