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Pushing the Frontiers of Modern Green Organic and Biochemical Analysis Techniques: A Themed Issue in Honor of Professor Milton L. Lee in Anticipation of His 75th Birthday

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 2065

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Royal Institute of Technology (KTH), Stockholm, Sweden
Interests: drug research; bioanalysis; sampling and sample preparation for biological samples; mass spectrometry; liquid and gas chromatography
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Dear Colleagues,

Milton L. Lee received a B.A. Degree in Chemistry from the University of Utah in 1971 and a Ph.D. in Analytical Chemistry from Indiana University in 1975 under the direction of Professor Milos V. Novotny. Dr. Lee spent one year (1975–1976) at the Massachusetts Institute of Technology as a Post­doctoral Research Associate with Professor Ronald A. Hites before accepting a faculty position in the Depart­ment of Chemistry and Biochemistry at Brigham Young University, where he became the H. Tracy Hall Professor of Chemistry. He has remained at Brigham Young University for his entire career of over 40 years.

Dr. Lee is best known for his research in capillary separation techniques and mass spectrometry detection. He is an author or co‑author of over 600 scientific publications and 500 technical present­a­tions describing research in which he has been involved for over 50 years. He has received a number of national and international awards, including the American Chemical Society Award in Chromatography (1988), Martin Gold Medal (1996), American Chemical Society Award in Chemical Instrumentation (1998), Eastern Analytical Symposium Award for Outstanding Achievements in Fields of Analytical Chemistry (2008), Pittsburgh Analytical Chemistry Award, (2008), the American Chemical Society Award in Separations Science and Technology (2012), both LCGC Europe (2014) and North America (2016) Lifetime Achievement Awards, Csaba Horvath Memorial Award (2018), and most recently the ACS Award in Analytical Chemistry (2019) and the Giorgia Nota Award (2019). He was named four times (2013, 2015, 2017, and 2019) by The Analytical Scientist as among the 100 most influential people in the analytical sciences. Dr. Lee has mentored over 100 graduate students and post-doctoral researchers.

Professor Lee is also an entrepreneur and has been involved in transferring technology from his university research laboratory to the private sector. He co‑founded four analytical instrument companies for commercialization of instrumentation in supercritical fluid chromatography, time-of-flight mass spectrometry, hand-portable gas chromatography-mass spectrometry, and, currently, hand-portable liquid chromatography. He is listed as a co-inventor on 20 issued patents.

Prof. Dr. Mohamed Abdel-Rehim
Guest Editor

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Keywords

  • Environmental analysis
  • Bioanalysis
  • Green chemistry
  • SFC
  • LC
  • GC
  • Sample preparation
  • High-performance materials

Published Papers (1 paper)

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Research

11 pages, 2144 KiB  
Article
Phthalylglycyl Chloride as a Derivatization Agent for UHPLC-MS/MS Determination of Adrenaline, Dopamine and Octopamine in Urine
by Maria Zorina, Victor V. Dotsenko, Pavel N. Nesterenko, Azamat Temerdashev, Ekaterina Dmitrieva, Yu-Qi Feng and Sanka N. Atapattu
Molecules 2023, 28(7), 2900; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules28072900 - 23 Mar 2023
Cited by 1 | Viewed by 1467
Abstract
Dopamine, adrenaline and octopamine are small polar molecules that play a vital role in regulatory systems. In this paper, phthalylglycyl chloride was proposed as a derivatization agent for octopamine, adrenaline and dopamine determination in urine for the first time. The derivatization procedure facilitated [...] Read more.
Dopamine, adrenaline and octopamine are small polar molecules that play a vital role in regulatory systems. In this paper, phthalylglycyl chloride was proposed as a derivatization agent for octopamine, adrenaline and dopamine determination in urine for the first time. The derivatization procedure facilitated the use of reversed-phase liquid chromatography with positive electrospray ionization–high-resolution mass spectrometry. An LC-HRMS method was developed that provided quantification limits of 5 ng/mL and detection limits of 1.5 ng/mL for all analytes. The 95–97% yield of derivates was observed after a 10 min derivatization with phthalylglycyl chloride at pH 6.5 and 30 °C. The proposed method was successfully applied to the analysis of human urine samples. The obtained results were compared with those of conventional derivatization procedures with 9-fluorenyl-methoxycarbonyl chloride and dansyl chloride. Full article
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