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Special Issue "Multivalent Self-Assembled Systems for Biological Applications"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Sébastien Ulrich
E-Mail Website
Guest Editor
IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier, France
Interests: self-assembly; self-assembled multivalency; supramolecular chemistry; dynamic covalent/combinatorial chemistry; gene delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Multivalency is a hallmark of biomolecular recognition that applies to nucleic acids, proteins, and carbohydrates. Multivalent binding by synthetic nano-constructs is inspired by numerous biological systems such as viruses, and bears strong potentials in biological/biomedical applications, for instance, for the treatment of cancer or infectious diseases, but also in targeted drug/gene/protein delivery and biosensing/bioimaging. Besides the rational or trial-and-error molecular engineering of multivalent systems, self-assembly approaches, using supramolecular or dynamic covalent chemistries, have emerged in the last two decades and have attracted growing interest as a successful strategy for the identification of multivalent binders, for instance, whose formation is template-assisted from dynamic combinatorial libraries. On top of that, those multivalent self-assembled systems are dynamic and responsive, which enables the adaptation and the smart control of their self-assembly and disassembly by physico-chemical effectors. This Special Issue of Molecules will be devoted to showcasing how self-assembly approaches can be implemented to provide the next generation of multivalent systems for biological applications.

Dr. Sébastien Ulrich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multivalency
  • Biomolecular recognition
  • Self-assembly
  • Supramolecular chemistry
  • Dynamic covalent/combinatorial chemistry

Published Papers (1 paper)

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Review

Review
Recent Development in the Design of Neoglycoliposomes Bearing Arborescent Architectures
Molecules 2021, 26(14), 4281; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26144281 - 15 Jul 2021
Viewed by 616
Abstract
This brief review highlights systematic progress in the design of synthetic glycolipid (neoglycolipids) analogs evolving from the conventional architectures of natural glycosphingolipids and gangliosides. Given that naturally occurring glycolipids are composed of only one hydrophilic sugar head-group and two hydrophobic lipid tails embedded [...] Read more.
This brief review highlights systematic progress in the design of synthetic glycolipid (neoglycolipids) analogs evolving from the conventional architectures of natural glycosphingolipids and gangliosides. Given that naturally occurring glycolipids are composed of only one hydrophilic sugar head-group and two hydrophobic lipid tails embedded in the lipid bilayers of the cell membranes, they usually require extraneous lipids (phosphatidylcholine, cholesterol) to confer their stability. In order to obviate the necessity for these additional stabilizing ingredients, recent investigations have merged dendrimer chemistry with that of neoglycolipid syntheses. This singular approach has provided novel glycoarchitectures allowing reconsidering the necessity for the traditional one to two hydrophilic/hydrophobic ratio. An emphasis has been provided in the recent design of modular arborescent neoglycolipid syntheses coined glycodendrimersomes. Full article
(This article belongs to the Special Issue Multivalent Self-Assembled Systems for Biological Applications)
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