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Natural Products from Plant-Associated Microorganisms

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3713

Special Issue Editor


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Guest Editor
Center for Mass Spectrometry (CMS), Department of Chemistry and Chemical Biology, Technische Universität Dortmund, Otto-Hahn-Str. 6, 44221 Dortmund, Germany
Interests: metabolomics; imaging mass spectrometry; natural product chemistry; microbial drug discovery; antimicrobials; plant–microbe interactions; chemical ecology; molecular ecology; endophytes; phytopathogens; biocontrol organisms; biologics
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Special Issue Information

Dear Colleagues,

It is now evident from a plethora of studies that the production of secondary metabolites by plants and associated microorganisms, ranging from antimicrobial chemical defense compounds to communication molecules, is the direct or indirect result of complex and dynamic ecological interactions in nature. Any plant ecosystem would be rendered virtually non-functional without the ecologically meaningful metabolites of plant-associated micro- and macrobiota. This Special Issue invites full research papers, reviews, and short communications dealing with natural products isolated from plant-associated microorganisms, such as endophytic microorganisms, having ecological, biological, physiological, or pharmaceutical implications. Studies dealing with the role of natural products in interspecies and multispecies crosstalk of plant-associated microorganisms and how these interactions correlate with natural products' biosynthesis and plant fitness costs/benefits are also invited. Studies on natural product isolation and characterization from plant-associated microorganisms reporting the use of state-of-the-art chemical, biological, genomic, computational, and interdisciplinary omics-approaches are particularly welcome.

Priv.-Doz. Dr. Souvik Kusari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural product chemistry
  • Structural elucidation
  • Structure–activity relationships
  • Biosynthesis of secondary metabolites
  • Bioactive and physiologically active natural products (e.g., allelochemicals, semiochemicals)
  • Endophytes, phytopathogens, bacteria, fungi, viruses, etc.
  • Fermentation, bioprocess design, upscaling

Published Papers (1 paper)

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Research

19 pages, 3884 KiB  
Article
Production of Siderophores by an Apple Root-Associated Streptomyces ciscaucasicus Strain GS2 Using Chemical and Biological OSMAC Approaches
by Reyhaneh Armin, Sebastian Zühlke, Gisela Grunewaldt-Stöcker, Felix Mahnkopp-Dirks and Souvik Kusari
Molecules 2021, 26(12), 3517; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules26123517 - 09 Jun 2021
Cited by 11 | Viewed by 3119
Abstract
Apple Replant Disease (ARD) is a significant problem in apple orchards that causes root tissue damage, stunted plant growth, and decline in fruit quality, size, and overall yield. Dysbiosis of apple root-associated microbiome and selective richness of Streptomyces species in the rhizosphere typically [...] Read more.
Apple Replant Disease (ARD) is a significant problem in apple orchards that causes root tissue damage, stunted plant growth, and decline in fruit quality, size, and overall yield. Dysbiosis of apple root-associated microbiome and selective richness of Streptomyces species in the rhizosphere typically concurs root impairment associated with ARD. However, possible roles of Streptomyces secondary metabolites within these observations remain unstudied. Therefore, we employed the One Strain Many Compounds (OSMAC) approach coupled to high-performance liquid chromatography-high-resolution tandem mass spectrometry (HPLC-HRMSn) to evaluate the chemical ecology of an apple root-associated Streptomycesciscaucasicus strain GS2, temporally over 14 days. The chemical OSMAC approach comprised cultivation media alterations using six different media compositions, which led to the biosynthesis of the iron-chelated siderophores, ferrioxamines. The biological OSMAC approach was concomitantly applied by dual-culture cultivation for microorganismal interactions with an endophytic Streptomyces pulveraceus strain ES16 and the pathogen Cylindrocarpon olidum. This led to the modulation of ferrioxamines produced and further triggered biosynthesis of the unchelated siderophores, desferrioxamines. The structures of the compounds were elucidated using HRMSn and by comparison with the literature. We evaluated the dynamics of siderophore production under the combined influence of chemical and biological OSMAC triggers, temporally over 3, 7, and 14 days, to discern the strain’s siderophore-mediated chemical ecology. We discuss our results based on the plausible chemical implications of S. ciscaucasicus strain GS2 in the rhizosphere. Full article
(This article belongs to the Special Issue Natural Products from Plant-Associated Microorganisms)
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