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Special Issue "Nutraceuticals and Their Medicinal Importance 2019"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (30 June 2019).

Special Issue Editor

Dr. Francesca Giampieri
grade E-Mail Website
Guest Editor
Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, 60131 Ancona, Italy
Interests: nutrition; health; disease prevention; dietary bioactive compounds; oxidative stress; aging; mitochondrial functionality; inflammation; bioenergetics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few years, numerous studies have demonstrated a wide range of biological properties and health benefits exerted by nutraceuticals, defined as a “food, or parts of a food, that provide medical or health benefits, including the prevention and treatment of disease”. These studies highlighted the beneficial role of nutraceuticals both in the prevention and in the treatment of several diseases, such as diabetes and metabolic syndrome, cancer, cardiovascular diseases, and osteoporosis and arthritis, with relevant consequences on quality of life and longevity. For these reasons, on the one hand, nutraceuticals have been included in conventional therapies, allowing the reduction of medication dosages and adverse effects, and, on the other hand, consumers have become aware that they may help to maintain good health and prevent diseases. This has led to a global annual increase of about 15% in the nutraceutical market.

The main aim of the Second Edition of this Special Issue on "Nutraceuticals and Their Medicinal Importance" is to be an open forum where researchers may share their investigations and findings in this promising field and, thanks to the open access platform, increase their visibility and the chances to interact with industries and the production systems. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of nutraceuticals; studies with multidisciplinary input, offering new methodologies or insights, are particularly welcome.

Dr. Francesca Giampieri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nutraceuticals
  • Bioactive compounds
  • Functional foods
  • Medicinal products
  • Health
  • Disease prevention
  • Quality control
  • Food processing techniques
  • Safety and efficacy
  • Bioavailability
  • Dietary supplements
  • Commercialization of nutraceuticals and functional foods
  • Economic and industry opportunities
  • Labeling and health claims

Published Papers (1 paper)

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Clitoria ternatea Flower Petal Extract Inhibits Adipogenesis and Lipid Accumulation in 3T3-L1 Preadipocytes by Downregulating Adipogenic Gene Expression
Molecules 2019, 24(10), 1894; - 17 May 2019
Cited by 13 | Viewed by 2301
Clitoria ternatea (commonly known as blue pea) flower petal extract (CTE) is used as a natural colorant in a variety of foods and beverages. The objective of study was to determine the inhibitory effect of CTE on adipogenesis in 3T3-L1 preadipocytes. The phytochemical [...] Read more.
Clitoria ternatea (commonly known as blue pea) flower petal extract (CTE) is used as a natural colorant in a variety of foods and beverages. The objective of study was to determine the inhibitory effect of CTE on adipogenesis in 3T3-L1 preadipocytes. The phytochemical profiles of CTE were analyzed by liquid chromatography and tandem mass spectrometry (LC-MS/MS). Anti-adipogenesis effect of CTE was measured by using Oil Red O staining, intracellular triglyceride assay, quantitative real-time PCR and western blot analysis in 3T3-L1 adipocytes. Cell cycle studies were performed by flow cytometry. Lipolysis experiments were performed using a colorimetric assay kit. In early stages, CTE demonstrated anti-adipogenic effects through inhibition of proliferation and cell cycle retardation by suppressing expression of phospho-Akt and phospho-ERK1/2 signaling pathway. The results also showed that CTE inhibited the late stage of differentiation through diminishing expression of adipogenic transcription factors including PPARγ and C/EBPα. The inhibitory action was subsequently attenuated in downregulation of fatty acid synthase and acetyl-CoA carboxylase, causing the reduction of TG accumulation. In addition, CTE also enhanced catecholamine-induced lipolysis in adipocytes. These results suggest that CTE effectively attenuates adipogenesis by controlling cell cycle progression and downregulating adipogenic gene expression. Full article
(This article belongs to the Special Issue Nutraceuticals and Their Medicinal Importance 2019)
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