New Insight and Applications of Antimicrobial Host Defence Peptides in Autoimmune Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 297
Special Issue Editors
Interests: immunology; autoimmune diseases; SNVs
Interests: immunomodulation and inflammation: understanding molecular processes that underlie chronic inflammation; delineating the immunomodulatory functions of host defence peptides in chronic inflammatory diseases, such as arthritis and asthma; development of immunomodulatory therapies using synthetic peptides for the control of inflammatory diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Widely produced by all living organisms, antimicrobial peptides, also known as host defence peptides,
comprise a large group of cationic and amphipatic molecules with low molecular weight. Antimicrobial
peptides, consitutively and/or inducibly produced by many cell types, have a broad spectrum of biological
functions, including antimicrobial activity, chemotactic activity and wound healing. Moreover, these
peptides play determinant roles in immune regulation and maintaining of immune homeostasis, by exerting
both pro- and anti-inflammatory functions based on the inflammatory milieu. Hence, dysregulation of
antimicrobial peptides has been found to be implicated in the susceptibility and progression of several
chronic disease, including autoimmune diseases. Moreover, dysbiosis of gut microbiota has been correlated
with the pathogenesis of some autoimmune diseases, suggesting that the crosstalk between these peptides
and the microbiome may play a role in the pathophysiology of autoimmunity.
Therefore, authors are invited to submit manuscripts to this Molecules Special Issue, to highlight
diverse aspects related to the role of antimicrobial host defence peptides in autoimmune disorders,
and their potential as diagnostic and therapeutic agents.
Dr. Fabio D'Amico
Dr. Neeloffer Mookherjee
Guest Editors
Manuscript Submission Information
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Keywords
- Antimicrobial peptides
- AMPs
- Autoimmune diseases.
