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Phytochemistry, Biological Activities and Applications of the Piperaceae

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 37677

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Special Issue Editors

Prof. Dr. William N. Setzer

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Guest Editor

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA
Interests: natural product drug discovery; phytochemistry; essential oils; chemical ecology; molecular modeling
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Joyce Kelly R. Da Silva

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Assistant Guest Editor

Faculty of Biotechnology, Federal University of Pará, Belém 66075-110, Brazil
Interests: Essential oils; Natural product drug discovery; Plant-pathogen interaction; Plant molecular biology.
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleague,

The Piperaceae is a large family with as many as 50 genera and nearly 4000 species. Members of the Piperaceae, especially Peperomia and Piper species, are rich sources of biologically active phytochemicals with a high structural diversity. In this special issue, we invite reviews and research articles that identify the chemical components, demonstrate the biological activities, and illustrate recent advances and discoveries in the Piperaceae.

Prof. William N. Setzer
Guest Editor

Prof. Joyce Kelly R. da Silva
Assistant Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

chemical composition
pharmacology
chemical ecology
biological assays

Published Papers (3 papers)

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Research

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13 pages, 431 KiB

Open AccessFeature PaperArticle

Volatiles of Black Pepper Fruits (Piper nigrum L.)

by Noura S. Dosoky, Prabodh Satyal, Luccas M. Barata, Joyce Kelly R. da Silva and William N. Setzer

Molecules 2019, 24(23), 4244; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24234244 - 21 Nov 2019

Cited by 52 | Viewed by 9540

Abstract

Black pepper (Piper nigrum) is historically one of the most important spices and herbal medicines, and is now cultivated in tropical regions worldwide. The essential oil of black pepper fruits has shown a myriad of biological activities and is a commercially important commodity. In this work, five black pepper essential oils from eastern coastal region of Madagascar and six black pepper essential oils from the Amazon region of Brazil were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. The major components of the essential oils were α-pinene, sabinene, β-pinene, δ-3-carene, limonene, and β-caryophyllene. A comparison of the Madagascar and Brazilian essential oils with black pepper essential oils from various geographical regions reported in the literature was carried out. A hierarchical cluster analysis using the data obtained in this study and those reported in the literature revealed four clearly defined clusters based on the relative concentrations of the major components. Full article

(This article belongs to the Special Issue Phytochemistry, Biological Activities and Applications of the Piperaceae)

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30 pages, 786 KiB

Open AccessArticle

Chemical Compositions and Mosquito Larvicidal Activities of Essential Oils from Piper Species Growing Wild in Central Vietnam

by Le Thi Huong, Nguyen Huy Hung, Do Ngoc Dai, Thieu Anh Tai, Vu Thi Hien, Prabodh Satyal and William N. Setzer

Molecules 2019, 24(21), 3871; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24213871 - 27 Oct 2019

Cited by 19 | Viewed by 4793

Abstract

Mosquitoes are the deadliest animals on earth and are the vectors of several neglected tropical diseases. Recently, essential oils have emerged as potential renewable, cost-effective, and environmentally benign alternatives to synthetic pesticides for control of mosquitoes. In this work, thirteen species of Piper were collected from different areas of central Vietnam. The essential oils were obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry. The essential oils were screened for mosquito larvicidal activity against Aedes aegypti. Four of the Piper essential oils showed outstanding larvicidal activity against Ae. aegypti, namely P. caninum, P. longum, P. montium, and P. mutabile, with LC₅₀ and LC₉₀ values less than 10 µg/mL. Multivariate analysis has correlated concentrations of β-caryophyllene, β-bisabolene, α-pinene, and β-pinene with mosquito larvicidal activity. Full article

(This article belongs to the Special Issue Phytochemistry, Biological Activities and Applications of the Piperaceae)

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Review

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118 pages, 1030 KiB

Open AccessReview

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

by Bahare Salehi, Zainul Amiruddin Zakaria, Rabin Gyawali, Salam A. Ibrahim, Jovana Rajkovic, Zabta Khan Shinwari, Tariq Khan, Javad Sharifi-Rad, Adem Ozleyen, Elif Turkdonmez, Marco Valussi, Tugba Boyunegmez Tumer, Lianet Monzote Fidalgo, Miquel Martorell and William N. Setzer

Molecules 2019, 24(7), 1364; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24071364 - 07 Apr 2019

Cited by 267 | Viewed by 22339

Abstract

Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed. Full article

(This article belongs to the Special Issue Phytochemistry, Biological Activities and Applications of the Piperaceae)

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